{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:50:38Z","timestamp":1791600638365,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Patients with coronary artery disease (CAD) and severely reduced left ventricular ejection fraction (LVEF) face high perioperative risks during surgical revascularization. This case series examines outcomes in CAD patients with LVEF \u2264\u200925% undergoing surgical revascularization on microaxial flow pump (mAFP) support.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 12 patients at Deutsches Herzzentrum der Charit\u00e9 who underwent scheduled protected coronary artery bypass grafting (CABG) with full\u2010flow mAFP support. Patients with acute myocardial infarction or no myocardial viability were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cohort had a median age of 60\u2009years [59; 66], 92% male, BMI 26\u2009\u00b1\u20096.2\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , median LVEF 18% [15; 24], and LVEDD 69\u2009mm [59; 78]. Seven patients had diabetes mellitus and chronic renal failure, and five had prior myocardial infarctions. The mean EUROSCORE II was 2.5\u2009\u00b1\u20090.6.\n                    <\/jats:p>\n                    <jats:p>Surgical revascularization was performed with ongoing mAFP support, with a median of 3 distal anastomoses. Complete revascularization was achieved in 11 cases and surgical time was 254\u2009min [187; 266]. Myocardial recovery occurred in seven patients, while four required durable left ventricular assist device implantation, and one died on mAFP support. Two (16.6%) patients died during a follow\u2010up period of 93\u2009days. Median Impella support lasted 6\u2009days [3; 9], invasive ventilation 13\u2009h [11; 20], and ICU stays 4.5\u2009days [4; 17].<\/jats:p>\n                    <jats:p>Complications included one bleeding requiring revision, two mAFP exchanges due to thrombosis\/dislodgement, and four thromboembolic strokes in three patients during mAFP explantation\/exchange.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Revascularization with mAFP support is a feasible approach for high\u2010risk CAD patients but is associated with support\u2010related complications, including thromboembolic strokes during mAFP manipulations (e.g., explantation or exchange). Prospective randomized trials are essential to evaluate the potential benefits of intraoperative mAFP support during surgical revascularization compared to alternative mechanical support strategies and\/or pharmacological measures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.15038","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T06:20:17Z","timestamp":1749018017000},"page":"1346-1355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Coronary Artery Bypass Grafting on Microaxial Flow Pump Support in Patients With Severely Reduced Left Ventricular Ejection Fraction"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9524-7705","authenticated-orcid":false,"given":"Gaik","family":"Nersesian","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery Deutsches Herzzentrum der Charit\u00e9 (DHZC)  Berlin Germany"},{"name":"DZHK (German Centre for Cardiovascular Research) Partner Site Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9831-6289","authenticated-orcid":false,"given":"Daniel","family":"Lewin","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery Deutsches Herzzentrum der Charit\u00e9 (DHZC)  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuriy","family":"Hrytsyna","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery Deutsches Herzzentrum der Charit\u00e9 (DHZC)  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Lanmueller","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery Deutsches Herzzentrum der Charit\u00e9 (DHZC)  Berlin Germany"},{"name":"DZHK (German Centre for Cardiovascular 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Germany"},{"name":"Berlin Institute of Health at Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Department of Health Sciences and Technology Institute of Translational Medicine, Translational Cardiovascular Technologies, Swiss Federal Institute of Technology (ETH) Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Schoenrath","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery Deutsches Herzzentrum der Charit\u00e9 (DHZC)  Berlin Germany"},{"name":"DZHK (German Centre for Cardiovascular Research) Partner Site Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgenij","family":"Potapov","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery Deutsches Herzzentrum der Charit\u00e9 (DHZC)  Berlin Germany"},{"name":"DZHK (German Centre for Cardiovascular Research) Partner Site 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