{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T21:04:54Z","timestamp":1763499894936,"version":"3.45.0"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T00:00:00Z","timestamp":1751673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001791","name":"Griffith University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001791","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002301","name":"Eesti Teadusagentuur","doi-asserted-by":"publisher","award":["PRG 2078"],"award-info":[{"award-number":["PRG 2078"]}],"id":[{"id":"10.13039\/501100002301","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018853","name":"Common Good","doi-asserted-by":"publisher","award":["TM2017\u201004"],"award-info":[{"award-number":["TM2017\u201004"]}],"id":[{"id":"10.13039\/501100018853","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To build a mock circulatory loop to simulate veno\u2010arterial extracorporeal membrane oxygenation (V\u2010A ECMO) haemodynamics using a patient\u2010specific silicone aortic phantom and compare the flow dynamics for continuous and pulsatile ECMO settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A silicone model of a human aorta with major branches was fabricated and the left iliac artery was cannulated using a Xenios ECMO device to simulate a peripheral V\u2010A ECMO configuration. The left ventricular outflows at the aortic root were simulated using a piston pump. Particle image velocimetry (PIV) experiments were conducted to measure flow velocities along the aortic phantom for a severe heart failure condition (LV\u2009=\u20091\u2009L\/min) supported by ECMO (4\u2009L\/min) at a heart rate of 80\u2009bpm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Comparing all ECMO support modes, counter pulse ECMO mode exhibited higher velocities during both peak systolic and mid\u2010diastolic phases. This shows that the LV and ECMO device supplied fluid into the aorta with less flow resistance, whereas other modes exhibited higher flow resistance due to the flow collision of antegrade LV and retrograde ECMO flow in the aorta.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pulsatile flow ECMO with better placement of ECMO pulse delivery in the cardiac cycle could develop greater pulsatility into the aorta, which is crucial for transferring haemodynamic energy and reducing cardiac afterload.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.15040","type":"journal-article","created":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T03:30:47Z","timestamp":1751686247000},"page":"1558-1570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Visualizing Flow Dynamics in a Human Aorta During Peripheral Veno\u2010Arterial Extracorporeal Membrane Oxygenation Treatment Through Particle Image Velocimetry Study"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2262-0919","authenticated-orcid":false,"given":"Dhayananth","family":"Kanagarajan","sequence":"first","affiliation":[{"name":"School of Engineering and Built Environment Griffith University  Gold Coast Queensland Australia"},{"name":"Innovative Cardiovascular Engineering and Technology Laboratory, Critical Care Research Group The Prince Charles Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clayton","family":"Semenzin","sequence":"additional","affiliation":[{"name":"School of Engineering and Built Environment Griffith University  Gold Coast Queensland Australia"},{"name":"Innovative Cardiovascular Engineering and Technology Laboratory, Critical Care Research Group The Prince Charles Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5004-4816","authenticated-orcid":false,"given":"Silver","family":"Heinsar","sequence":"additional","affiliation":[{"name":"Innovative Cardiovascular Engineering and Technology Laboratory, Critical Care Research Group The Prince Charles Hospital  Brisbane Queensland Australia"},{"name":"Department of Intensive Care North Estonia Medical Centre  Tallinn Estonia"},{"name":"Department of Cardiology, Institute of Clinical Medicine University of Tartu  Tartu Estonia"},{"name":"Faculty of Medicine University of Queensland  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Van Thanh","family":"Dau","sequence":"additional","affiliation":[{"name":"School of Engineering and Built Environment Griffith University  Gold Coast Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4994-5967","authenticated-orcid":false,"given":"Jo P.","family":"Pauls","sequence":"additional","affiliation":[{"name":"School of Engineering and Built Environment Griffith University  Gold Coast Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey D.","family":"Tansley","sequence":"additional","affiliation":[{"name":"School of Engineering and Built Environment Griffith University  Gold Coast Queensland Australia"},{"name":"Innovative Cardiovascular Engineering and Technology Laboratory, Critical Care Research Group The Prince Charles Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John F.","family":"Fraser","sequence":"additional","affiliation":[{"name":"Innovative Cardiovascular Engineering and Technology Laboratory, Critical Care Research Group The Prince Charles Hospital  Brisbane 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