{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:15:43Z","timestamp":1787656543729,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We previously reported the EXTEND (EXTra\u2010uterine Environment for Neonatal Development) system provides physiologic support of fetal lambs (105\u2013111\u2009days gestational age; GA) via a pumpless arteriovenous circuit using a commercially available oxygenator (Maquet\u2010Ox). However, for anticipated human subjects at 23\u201328\u2009weeks of GA, a smaller oxygenator is required. To meet this requirement, a proprietary oxygenator (Experimental Oxygenator: Exp\u2010Ox) was developed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fourteen lambs (mean GA 99\u2009days, mean weight at cannulation 1.36\u2009kg) were placed on the EXTEND system. Thereafter, Exp\u2010Ox was connected in parallel with the Maquet\u2010Ox, and its durability and hemocompatibility were assessed over a prolonged use of up to 21\u2009days, utilizing a dual oxygenator platform. Blood flow to Exp\u2010Ox was increased over time using a tubing clamp to maintain the anticipated human fetal flow rates (50\u2013165\u2009mL\/min).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Throughout the study, there was no deterioration in the oxygen and CO\n                      <jats:sub>2<\/jats:sub>\n                      exchange function. The pressure drop in the Exp\u2010Ox remained unchanged over time, with no statistically significant difference, whereas the calculated Exp\u2010Ox resistance (pressure drop\/blood flow) decreased since the change in pressure drop increased at a slower rate than the increase in blood flow. The quantitative clot burden in the Exp\u2010Ox following completion of the study ranged from 0.03% to 2.55%, with no correlation to study duration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The study demonstrated the Exp\u2010Ox maintained its ability to transfer oxygen and CO2 and sustained hemocompatibility for up to 21\u2009days at anticipated fetal flow rates on the EXTEND system.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.15049","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T07:55:24Z","timestamp":1751356524000},"page":"1660-1670","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of Gas Exchange and Hemocompatibility of an Experimental Oxygenator at Anticipated Human Fetal Flow Rates in Fetal Lambs Using a Dual Oxygenator Platform in the\n                    <scp>EXTra<\/scp>\n                    \u2010Uterine Environment for Neonatal Development (\n                    <scp>EXTEND<\/scp>\n                    ) System"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9222-3487","authenticated-orcid":false,"given":"Seitaro","family":"Kosaka","sequence":"first","affiliation":[{"name":"Center for Fetal Research Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urgyen","family":"Wangmo","sequence":"additional","affiliation":[{"name":"Center for Fetal Research Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoya","family":"Butt","sequence":"additional","affiliation":[{"name":"Center for Fetal Research Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apeksha","family":"Dave","sequence":"additional","affiliation":[{"name":"Center for Fetal Research Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4858-7846","authenticated-orcid":false,"given":"Kevin B.","family":"Hayes","sequence":"additional","affiliation":[{"name":"Center for Fetal Research Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alia Mohsin","family":"Choudhry","sequence":"additional","affiliation":[{"name":"Center for Fetal Research Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer A.","family":"Khan","sequence":"additional","affiliation":[{"name":"Center for Fetal Research Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Ngo","sequence":"additional","affiliation":[{"name":"Center for Fetal Research Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah R.","family":"Weisman","sequence":"additional","affiliation":[{"name":"Center for Fetal Research Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel S.","family":"White","sequence":"additional","affiliation":[{"name":"Center for Fetal Research Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria F.","family":"Varela","sequence":"additional","affiliation":[{"name":"Center for Fetal Research Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy C.","family":"Herrera Cruz","sequence":"additional","affiliation":[{"name":"Vitara Biomedical Inc.  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Crompton","sequence":"additional","affiliation":[{"name":"Vitara Biomedical Inc.  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus G.","family":"Davey","sequence":"additional","affiliation":[{"name":"Vitara Biomedical Inc.  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan W.","family":"Flake","sequence":"additional","affiliation":[{"name":"Center for Fetal Research Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018-0933"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15112"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12656"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70456-4"},{"key":"e_1_2_9_6_1","unstructured":"\u201cRheosense Application Brief: Intrinsic Viscosity Measurement for Optimal Therapeutic Formulation\u201d."},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-44551"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1989.50.01.59"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198107000-00014"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00352"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.13827"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.03.001"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2011.01324.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001862"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000394"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10047-023-01389-w"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2020.tb00130.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2011.566948"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2014.02.014"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1191\/0267659105pf796oa"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6137"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40635-019-0264-z"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12687"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9103272"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.15049","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T08:42:09Z","timestamp":1767429729000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.15049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":23,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/aor.15049"],"URL":"https:\/\/doi.org\/10.1111\/aor.15049","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2024-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}