{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T12:18:05Z","timestamp":1782908285352,"version":"3.54.5"},"reference-count":10,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic kidney disease (CKD) is associated with disturbances in mineral and bone metabolism, increasing fracture risk, particularly in advanced stages. Bone turnover markers (BTMs) such as bone alkaline phosphatase (BALP) and tartrate\u2010resistant acid phosphatase 5b (TRACP5b), as well as collagen\u2010derived markers including intact form of procollagen type I amino\u2010terminal propeptide (iPINP) and \u03b2\u2010cross\u2010linked C\u2010terminal telopeptide of type I collagen (\u03b2\u2010CTX\u2010I), are recommended to assess bone turnover. Although some BTMs are considered stable and independent of renal function, their behavior during dialysis sessions remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To assess the impact of dialysis techniques and membrane types, serum samples were collected pre\u2010 and post\u2010dialysis. BTM concentrations were analyzed using nonparametric statistics, and the clinical relevance of the observed changes was evaluated using the least significant change (LSC) thresholds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>BALP and TRACP5b showed minor fluctuations post\u2010dialysis, with changes remaining below their clinical significance thresholds. iPINP also showed limited variability. In contrast, \u03b2\u2010CTX\u2010I decreased significantly after hemodialysis, especially using high\u2010permeability membranes, with changes exceeding the LSC threshold.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that BALP, TRACP5b, and PINP demonstrate robustness as BTMs in CKD patients undergoing dialysis. However, \u03b2\u2010CTX\u2010I is markedly affected by dialysis parameters and should be interpreted cautiously in this context.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.15053","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T10:46:08Z","timestamp":1751366768000},"page":"1588-1591","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Changes in Bone Turnover Markers Associated With a Single Dialysis Session"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8223-503X","authenticated-orcid":false,"given":"Alix","family":"Mackowiak","sequence":"first","affiliation":[{"name":"Clinical Chemistry, Center for Interdisciplinary Research on Medicines (CIRM) University of Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Bouquegneau","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Transplantation University Hospital of Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Dubois","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Transplantation University Hospital of Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Grifn\u00e9e","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry University Hospital of Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Demeuse","sequence":"additional","affiliation":[{"name":"Clinical Chemistry, Center for Interdisciplinary Research on Medicines (CIRM) University of Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Le Goff","sequence":"additional","affiliation":[{"name":"Clinical Chemistry, Center for Interdisciplinary Research on Medicines (CIRM) University of Li\u00e8ge  Li\u00e8ge Belgium"},{"name":"Department of Clinical Chemistry University Hospital of Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Loberg Haarhaus","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine, Department of Clinical Sciences, Intervention and Technology Karolinska Institutet, University Hospital of Karolinska  Stockholm Sweden"},{"name":"Diaverum Sweden  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Magnusson","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry Link\u00f6ping University  Link\u00f6ping Sweden"},{"name":"Department of Biomedical and Clinical Sciences Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0881-2615","authenticated-orcid":false,"given":"Hanne Skou","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation, Nephrology and Renal Transplantation Research Group University of Leuven  Leuven Belgium"},{"name":"Department of Clinical Medicine University of Aarhus  Aarhus Denmark"},{"name":"Department of Nephrology University Hospital of Aalborg  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Evenepoel","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation, Nephrology and Renal Transplantation Research Group University of Leuven  Leuven Belgium"},{"name":"Department of Nephrology and Renal Transplantation University of Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Delanaye","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Transplantation University Hospital of Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Cavalier","sequence":"additional","affiliation":[{"name":"Clinical Chemistry, Center for Interdisciplinary Research on Medicines (CIRM) University of Li\u00e8ge  Li\u00e8ge Belgium"},{"name":"Department of Clinical Chemistry University Hospital of Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.188"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000798"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2019.11.012"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223\u2010008\u20109127\u20104"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft275"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620\u2010017\u20100408\u20108"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.5301\/ijao.5000565"},{"key":"e_1_2_7_9_1","unstructured":"EFLM Biological Variation accessed February 4 2025 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Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.15053","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T21:01:21Z","timestamp":1763499681000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.15053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/aor.15053"],"URL":"https:\/\/doi.org\/10.1111\/aor.15053","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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