{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T08:47:06Z","timestamp":1767430026230,"version":"3.48.0"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T00:00:00Z","timestamp":1754092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100021778","name":"Agencia Nacional de Promoci\u00f3n de la Investigaci\u00f3n, el Desarrollo Tecnol\u00f3gico y la Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021778","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003947","name":"Universidad Nacional de La Plata","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>One of the main challenges in control algorithm design for full closed\u2010loop automated insulin delivery systems is the trade\u2010off between the effective compensation of meal\u2010related disturbances and ensuring user safety during the postprandial and fasting periods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This paper proposes and evaluates the performance of a switched tuning strategy, a promising but relatively underexplored solution in this domain. This method employs two distinct tunings of a primary control algorithm: an aggressive tuning for meal compensation and a conservative tuning for fasting periods. The analysis considers implementing the switched strategy for three control algorithms: model predictive control and proportional\u2010derivative control, both widely used for glucose regulation, and a linear quadratic Gaussian control, an optimal algorithm previously validated in clinical settings under a switched structure. Additionally, to obtain a more comprehensive understanding of the switched strategy implications, two nonswitched controllers are implemented for each control algorithm: an aggressive and a conservative tuning strategy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The switched strategy significantly improves the trade\u2010off between meal compensation and safety, increasing the time within the target range of 70\u2013180 [mg\/dL] for all three algorithms. For proportional\u2010derivative control, the time in range increases from 69.1% with the conservative tuning and 83.1% with the aggressive to 86.6% with the switched structure. For model predictive control, the improvement is from 73.4% and 74.1% to 85.8%. Last, linear quadratic Gaussian control increases from 65.0% and 70.4% to 85.6%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings suggest that the switched strategy may be a feasible and straightforward approach for enhancing meal compensation without increasing the risk of postprandial hypoglycemia in people with diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.15064","type":"journal-article","created":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T07:45:20Z","timestamp":1754120720000},"page":"1671-1680","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Switched Controllers in Fully Closed Loop Insulin Delivery Systems: Reducing the Trade\u2010Off Between Prandial Control and Safety"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9306-4881","authenticated-orcid":false,"given":"Fernando Leonel","family":"Da Rosa Jurao","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones en Electr\u00f3nica, Control y Procesamiento de Se\u00f1ales \u2010 LEICI (UNLP\u2010CONICET) Facultad de Ingenier\u00eda, Universidad Nacional de La Plata  La Plata Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5820-3108","authenticated-orcid":false,"given":"Emilia","family":"Fushimi","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Electr\u00f3nica, Control y Procesamiento de Se\u00f1ales \u2010 LEICI (UNLP\u2010CONICET) Facultad de Ingenier\u00eda, Universidad Nacional de La Plata  La Plata Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8473-1569","authenticated-orcid":false,"given":"Fabricio","family":"Garelli","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Electr\u00f3nica, Control y Procesamiento de Se\u00f1ales \u2010 LEICI (UNLP\u2010CONICET) Facultad de Ingenier\u00eda, Universidad Nacional de La Plata  La Plata Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31320-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnac022"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.13704"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad068"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2589-7500(19)30003-2"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2021.0319"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0442"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3842"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.919942"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcontrol.2024.100937"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.automatica.2018.01.025"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ifacol.2023.10.274"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/19322968211059159"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bspc.2019.101603"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2021.3116376"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2017.2652062"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conengprac.2018.02.003"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/19322968221096162"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/1932296818786488"},{"volume-title":"Control System Design","year":"2001","author":"Goodwin G. 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