{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T16:52:53Z","timestamp":1773766373579,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The long\u2010term benefit of polymyxin B hemadsorption (PMX\u2010HA) in septic shock patients remains unclear and may depend on the site of infection. We evaluated the association between PMX\u2010HA use and 1\u2010year mortality in patients with intra\u2010abdominal infection (IAI) and extra\u2010abdominal infection (EAI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed adult patients with septic shock (Sepsis\u20103) admitted to an ICU between January 2017 and July 2023. Patients were categorized as IAI or EAI and further stratified by PMX\u2010HA use. One\u2010year mortality was assessed using Kaplan\u2013Meier analysis, multivariable Cox regression (adjusted for age, sex, and SOFA score), and inverse probability of treatment weighting (IPTW), balancing age, sex, SOFA, CRRT use, and with or without surgical and\/or radiological interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 182 patients (98 IAI, 84 EAI), PMX\u2010HA was administered to 71 IAI and 32 EAI patients. In the IAI group, PMX\u2010HA was associated with significantly lower 1\u2010year mortality (32.3% vs. 59.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005), supported by Cox regression (adjusted HR: 0.485; 95% CI: 0.252\u20130.935;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031) and IPTW (weighted HR: 0.415; 95% CI: 0.215\u20130.787;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007). In contrast, in the EAI group, 1\u2010year mortality was similar between the non\u2010PMX and PMX groups (44.4% vs. 56.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.516), with no significant association in Cox analysis (adjusted HR: 0.790; 95% CI: 0.404\u20131.543;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.49) or IPTW (weighted HR: 0.85; 95% CI: 0.446\u20131.617;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.62).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PMX\u2010HA was significantly associated with a lower risk of 1\u2010year mortality in patients with IAI, but not in those with EAI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.70023","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T09:50:01Z","timestamp":1759917001000},"page":"271-280","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differential Impact of Polymyxin B Hemadsorption on Long\u2010Term Mortality in Septic Shock: A Retrospective Analysis of Intra\u2010Abdominal Versus Extra\u2010Abdominal Infections"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5990-0498","authenticated-orcid":false,"given":"Tomoki","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Critical and Intensive Care Medicine Shiga University of Medical Science  Otsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Fujino","sequence":"additional","affiliation":[{"name":"Department of Critical and Intensive Care Medicine Shiga University of Medical Science  Otsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Tsujita","sequence":"additional","affiliation":[{"name":"Department of Critical and Intensive Care Medicine Shiga University of Medical Science  Otsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yugo","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Shiga University of Medical Science Emergency and Intensive Care Unit  Otsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhiro","family":"Fujino","sequence":"additional","affiliation":[{"name":"Shiga University of Medical Science Emergency and Intensive Care Unit  Otsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidemitsu","family":"Miyatake","sequence":"additional","affiliation":[{"name":"Shiga University of Medical Science Emergency and Intensive Care Unit  Otsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Mizumura","sequence":"additional","affiliation":[{"name":"Shiga University of Medical Science Emergency and Intensive Care Unit  Otsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junji","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Shiga University of Medical Science Emergency and Intensive Care Unit  Otsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuma","family":"Kishimoto","sequence":"additional","affiliation":[{"name":"Shiga University of Medical Science Emergency and Intensive Care Unit  Otsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Shiomi","sequence":"additional","affiliation":[{"name":"Department of Critical and Intensive Care Medicine Shiga University of Medical Science  Otsu Japan"},{"name":"Shiga University of Medical Science Emergency and Intensive Care Unit  Otsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32989-7"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc12616"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-16373-0_19"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002362"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.856"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-3751-z"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.14618"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-5004-9"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001533"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-021-00928-z"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000444474"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-018-5463-7"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ams2.446"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000153"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000194535.82812.BA"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc12570"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199811000-00016"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200009000-00011"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1214\/09-STS313"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"issue":"1","key":"e_1_2_10_23_1","first-page":"22","article-title":"Hemoperfusion in Clinical Practice: The Picture From an Unbound Collaborative Registry","volume":"37","author":"Polymyxin B.","year":"2014","journal-title":"Blood Purification"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-016-0178-9"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/09680519040100040501"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2003.12.067"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2012.06.023"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-018-2077-y"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3181e14ca0"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI82224"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489920"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.12339"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3181a2a978"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-025-05422-7"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.13655"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.13550"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-005-0366-5"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.14534"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc5780"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc13912"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-019-0386-0"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.70023","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aor.70023","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.70023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:24:27Z","timestamp":1773757467000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.70023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,8]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/aor.70023"],"URL":"https:\/\/doi.org\/10.1111\/aor.70023","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,8]]},"assertion":[{"value":"2025-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}