{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:39:38Z","timestamp":1785451178982,"version":"3.56.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T00:00:00Z","timestamp":1763856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T00:00:00Z","timestamp":1763856000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>To date, it remains unclear to what extent dialyzer performance is affected by clotting, and which hemocompatibility parameters can reliably predict this phenomenon. This study investigated the relationship between dialyzer clotting, performance, and hemocompatibility in four commercially available dialyzers under conditions of intentionally reduced anticoagulation. This crossover study included 10 chronic hemodialysis patients, who were randomized over four dialyzers: FX CorAL800, FX CorDiax800, xevonta Hi20 (all polysulfone\u2010based), and Solacea\u201019H (cellulose\u2010based). Patients received a single bolus of one\u2010quarter of their standard Low\u2010Molecular\u2010Weight Heparin (LMWH) dose. Dialysis efficiency was assessed from toxin clearance of urea, \u03b22\u2010microglobulin, and myoglobin. Fiber patency was evaluated through visual scoring and \u03bcCT imaging. Hemocompatibility markers, including platelet counts, leukocyte counts, anti\u2010Xa activity, thrombin\u2010antithrombin complex (TAT), beta\u2010thromboglobulin (\u03b2\u2010TG), and neutrophil\u2010activating peptide (NAP\u20102), were also analyzed. \u03bcCT analysis showed that Solacea dialyzer demonstrated superior fiber patency compared to the other dialyzers. However, fiber blockage did not compromise dialysis performance, as all dialyzers maintained effective toxin removal. Platelet and leukocyte counts remained stable with FX CorAL and Solacea, while declines were found in FX CorDiax and xevonta. No significant correlations were found between clotting parameters and fiber blockage. Hence, under reduced anticoagulation, the cellulose\u2010based Solacea dialyzer exhibited superior fiber patency, but this did not result in higher middle molecule clearance. Since no correlation was found between fiber patency, dialysis performance, or clotting parameters, the underlying cause of the observed differences in dialyzer blockage remains unclear.<\/jats:p>","DOI":"10.1111\/aor.70039","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T04:10:41Z","timestamp":1763957441000},"page":"30-40","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Randomized Cross\u2010Over Study to Examine Associations Between Dialyzer Clotting, Uremic Toxin Removal, and Hemocompatibility During Post\u2010Dilution Hemodiafiltration With Reduced Anticoagulation"],"prefix":"10.1111","volume":"50","author":[{"given":"Sunny","family":"Eloot","sequence":"first","affiliation":[{"name":"Ghent University Hospital, Nephrology  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansgar","family":"Erlenk\u00f6tter","sequence":"additional","affiliation":[{"name":"Fresenius Medical Care Deutschland GmbH, VS Dialyzers, Care Enablement  St. Wendel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Zawada","sequence":"additional","affiliation":[{"name":"Fresenius Medical Care Deutschland GmbH, VS Dialyzers, Care Enablement  St. Wendel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n","family":"Josipovic","sequence":"additional","affiliation":[{"name":"Ghent University, Centre for X\u2010Ray Tomography, Physics and Astronomy  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7573-9833","authenticated-orcid":false,"given":"Alfred","family":"Gagel","sequence":"additional","affiliation":[{"name":"Fresenius Medical Care Deutschland GmbH, VS Machines, Care Enablement  Schweinfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Van Biesen","sequence":"additional","affiliation":[{"name":"Ghent University Hospital, Nephrology  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"De Somer","sequence":"additional","affiliation":[{"name":"Ghent University Hospital, Cardiac Surgery  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Griet","family":"Glorieux","sequence":"additional","affiliation":[{"name":"Ghent University Hospital, Nephrology  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7559-2579","authenticated-orcid":false,"given":"Katrien","family":"Devreese","sequence":"additional","affiliation":[{"name":"Ghent University Hospital, Coagulation Laboratory  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Boone","sequence":"additional","affiliation":[{"name":"Ghent University, Centre for X\u2010Ray Tomography, Physics and Astronomy  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Griesshaber","sequence":"additional","affiliation":[{"name":"Fresenius Medical Care Deutschland GmbH, Global Biomedical Evidence Generation, Global Medical Office  Bad Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floris","family":"Vanommeslaeghe","sequence":"additional","affiliation":[{"name":"Ghent University Hospital, Nephrology  Ghent 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