{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T20:35:50Z","timestamp":1777408550130,"version":"3.51.4"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013348","name":"Innosuisse - Schweizerische Agentur f\u00fcr Innovationsf\u00f6rderung","doi-asserted-by":"publisher","award":["56642.1 IP\u2010LS"],"award-info":[{"award-number":["56642.1 IP\u2010LS"]}],"id":[{"id":"10.13039\/501100013348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Many cardiac surgical procedures use cardiopulmonary bypass (CPB), which in neonates requires the heart\u2010lung machine (HLM) to be positioned close to the patient due to their small circulating blood volume. The absence of an MR\u2010compatible blood pump to be used in CPB remains a key challenge for studying perioperative brain injury mechanisms in this high\u2010risk group. This study aims to take the first step toward MR\u2010conditional HLMs by developing hardware, verifying pump hydraulics, and ensuring MR compatibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study presents three MR\u2010conditional blood pump prototypes: a roller pump, a non\u2010occlusive roller pump, and a centrifugal pump. MR compatibility was assessed by monitoring for imaging interference during scanning. Hydraulic performance was evaluated with pressure\u2014flow diagrams using a mock circulation test bench.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      None of the prototypes interfered with MR imaging, and although SNR was reduced by \u22128.43%\u2009\u00b1\u20097.96%, image quality remained sufficient for reliable assessment of relevant brain regions. Roller and non\u2010occlusive pumps maintained stable flow across pressure heads, with reductions of \u22124.46\u2009\u00b1\u20098.02 and \u2212119.33\u2009\u00b1\u200918.22\u2009mL\/min, respectively. The centrifugal pump exhibited pressure\u2010dependent performance (slope \u22122.21\u2009\u00b1\u20090.45\u2009mmHg\/[L\/min]). All pumps generated non\u2010pulsatile flow (SHE &lt;\u20091000 erg\/cm\n                      <jats:sup>3<\/jats:sup>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>All three pumps meet basic MR\u2010conditionality and flow requirements, supporting their potential for use in MRI\u2010guided studies during neonatal cardiac surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.70041","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T09:14:16Z","timestamp":1763370856000},"page":"393-403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hydraulic In\u00a0Vitro Characterization of\n                    <scp>MR<\/scp>\n                    \u2010Conditional Blood Pumps"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0188-6726","authenticated-orcid":false,"given":"Dominik T.","family":"Schulte","sequence":"first","affiliation":[{"name":"Institute for Dynamic Systems and Control ETH Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Renggli","sequence":"additional","affiliation":[{"name":"Product Development Group Zurich ETH Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Richter","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Research Unit, Vetsuisse Faculty University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8996-1961","authenticated-orcid":false,"given":"Francesca","family":"Del Chicca","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Research Unit, Vetsuisse Faculty University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Center for Cardiac Surgery, University Hospital Zurich University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin O.","family":"Schmiady","sequence":"additional","affiliation":[{"name":"Center for Cardiac Surgery, University Hospital Zurich University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6411-8871","authenticated-orcid":false,"given":"Marianne","family":"Schmid Daners","sequence":"additional","affiliation":[{"name":"Institute for Dynamic Systems and Control ETH Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Cardiac Surgery","author":"Senst B.","year":"2022"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/ija.IJA_379_17"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012369367-9\/50821-1"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.001089"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2003.09.053"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.08.022"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","unstructured":"S. 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