{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T02:19:35Z","timestamp":1787451575237,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Obesity and advanced heart failure (HF) increasingly intersect in clinical practice, yet their combined influence on outcomes following durable left ventricular assist device (LVAD) implantation remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a systematic review and meta\u2010analysis in accordance with PRISMA 2020, searching six databases to June 2025. Twenty\u2010six cohort studies encompassing 14\u2009100 adults (4982 obese; 9118 non\u2010obese) met inclusion criteria. Pooled odds ratios (ORs) and risk ratios (RRs) were generated using random\u2010effects models for mortality and adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Obese LVAD recipients were younger, more often female, and had higher prevalences of diabetes, hypertension, and sleep apnea than non\u2010obese patients. Short\u2010term mortality did not differ significantly between groups (OR 0.80, 95% CI 0.59\u20131.08). Similarly, follow\u2010up mortality at \u2265\u20091\u2009year showed no significant difference, although obese patients tended to have lower risk (RR 0.81, 95% CI 0.56\u20131.17). In contrast, obesity was associated with a distinct complication profile: higher risks of device\u2010related infection (RR 1.48, 95% CI 1.26\u20131.75), pump thrombosis\/device malfunction (OR 1.57, 95% CI 1.37\u20131.81), and right heart failure (RR 1.23, 95% CI 1.08\u20131.39). Rates of stroke, arrhythmia, respiratory failure, and major bleeding did not differ significantly between obese and non\u2010obese patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Obesity does not confer excess short\u2010term or long\u2010term mortality after durable LVAD implantation but is associated with substantially higher risks of infection, pump thrombosis, and right heart failure. These findings suggest that obesity alone should not preclude LVAD candidacy, while underscoring the need to recognize and manage the increased morbidity burden in this population and to further investigate outcomes in contemporary, device\u2010specific cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.70071","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:41:21Z","timestamp":1765600881000},"page":"660-673","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Obesity on Durable Left Ventricular Assist Device Implantation: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"50","author":[{"given":"Hugh","family":"Jacobs","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery Bristol Heart Institute  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9421-1010","authenticated-orcid":false,"given":"Olivia","family":"Frost","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, St George's Hospital St George's University Hospitals NHS Foundation  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4931-4049","authenticated-orcid":false,"given":"Arian Arjomandi","family":"Rad","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Oxford Heart Centre Oxford University NHS Foundation Trust  Oxford UK"},{"name":"Department of Cardiothoracic Surgery Maastricht University Medical Center+  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing Kiu","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Oxford Heart Centre Oxford University NHS Foundation Trust  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadeq","family":"Al\u2010Saegh","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic, Transplant and Vascular Surgery Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Zubarevich","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic, Transplant and Vascular Surgery Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Weymann","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic, Transplant and Vascular Surgery Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjang","family":"Ruhparwar","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic, Transplant and Vascular Surgery Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukman","family":"Amanov","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic, Transplant and Vascular Surgery Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peyman","family":"Sardari Nia","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Maastricht University Medical Center+  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonios","family":"Kourliouros","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Oxford Heart Centre Oxford University NHS Foundation Trust  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanos","family":"Athanasiou","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001303"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.16197"},{"key":"e_1_2_10_4_1","volume-title":"Prevalence of Overweight, Obesity, and Severe Obesity Among Adults Aged 20 and Over: United States, 1960\u20131962 Through 2017\u20132018","author":"Fryar C. 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