{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T06:03:14Z","timestamp":1780552994637,"version":"3.54.1"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004329","name":"The Slovenian Research and Innovation Agency","doi-asserted-by":"publisher","award":["P3\u20100323"],"award-info":[{"award-number":["P3\u20100323"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"The Slovenian Research and Innovation Agency","doi-asserted-by":"publisher","award":["P3\u20100108"],"award-info":[{"award-number":["P3\u20100108"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"The Slovenian Research and Innovation Agency","doi-asserted-by":"publisher","award":["L3\u20101838"],"award-info":[{"award-number":["L3\u20101838"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Regional citrate anticoagulation (RCA) improves the biocompatibility of hemodialysis (HD) by reducing activation of complement, leukocytes, and platelets. Despite the new possibility of expanded hemodialysis (HDx), RCA and unfractionated heparin (UFH) have not been compared in this dialysis modality. This study compared the biocompatibility and efficacy of RCA versus full\u2010dose UFH during HDx.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In a randomized cross\u2010over trial, 32 chronic HD patients each underwent two HDx sessions with a Theranova dialyzer: one with RCA and one with UFH. Biocompatibility was assessed by plasma complement factor 3a (C3a), myeloperoxidase (MPO), and platelet factor 4 (PF4) measured pre\u2010HDx, after 15\u2009min, and at session end. In a subset of patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095), scanning electron microscopy (SEM) visualized cell adhesion and clotting on dialyzer fibers. Efficacy outcomes were overall clearances and reduction ratios (RR) for creatinine, urea, and \u03b22\u2010microglobulin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      MPO and C3a increased after 15\u2009min of HDx only with UFH (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In the available PF4 data, a significant increase after 15\u2009min of HDx occurred only with UFH (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). SEM showed minimal cell adhesion with both anticoagulants. Overall clearances and RRs of creatinine, urea, and \u03b22\u2010microglobulin did not differ. RCA was well tolerated, with no significant electrolyte disturbances.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RCA during HDx provided superior biocompatibility over UFH, eliminating complement, granulocyte, and platelet activation without improving dialysis efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.70085","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T11:10:14Z","timestamp":1767697814000},"page":"809-812","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Biocompatibility and Efficacy of Regional Citrate Anticoagulation and Unfractionated Heparin During Expanded Hemodialysis With a Medium Cut\u2010Off Membrane: A Randomized Trial"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6891-9441","authenticated-orcid":false,"given":"Marija","family":"Malgaj Vre\u010dko","sequence":"first","affiliation":[{"name":"Department of Nephrology University Medical Centre Ljubljana  Ljubljana Slovenia"},{"name":"Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jernej","family":"Pajek","sequence":"additional","affiliation":[{"name":"Department of Nephrology University Medical Centre Ljubljana  Ljubljana Slovenia"},{"name":"Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5394-3729","authenticated-orcid":false,"given":"Jakob","family":"Guben\u0161ek","sequence":"additional","affiliation":[{"name":"Department of Nephrology University Medical Centre Ljubljana  Ljubljana Slovenia"},{"name":"Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samo","family":"Hudoklin","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology, Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u0161ko","family":"Osredkar","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy University of Ljubljana  Ljubljana Slovenia"},{"name":"Institute of Clinical Chemistry and Biochemistry University Medical Centre Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1879-6353","authenticated-orcid":false,"given":"Mojca","family":"Bo\u017ei\u010d Mijovski","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy University of Ljubljana  Ljubljana Slovenia"},{"name":"Department of Vascular Diseases University Medical Centre Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ale\u0161","family":"Jerin","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy University of Ljubljana  Ljubljana Slovenia"},{"name":"Institute of Clinical Chemistry and Biochemistry University Medical Centre Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jadranka","family":"Buturovi\u0107\u2010Ponikvar","sequence":"additional","affiliation":[{"name":"Department of Nephrology University Medical Centre Ljubljana  Ljubljana Slovenia"},{"name":"Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfi069"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2011.00996.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/12.7.1387"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-15-19"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00071"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2005.10.001"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.130"},{"issue":"1","key":"e_1_2_10_9_1","first-page":"S43","article-title":"Optimization of Heparin Anticoagulation for Hemodialysis","volume":"15","author":"Davenport A.","year":"2011","journal-title":"Hemodialysis 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