{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:47:57Z","timestamp":1777632477610,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To compare overall and hemocompatibility\u2010related outcomes across third\u2010generation centrifugal\u2010flow HeartMate 3 (HM3) versus second\u2010generation axial\u2010flow HeartMate II (HMII) and centrifugal\u2010flow HeartWare (HVAD) in routine clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a multicenter observational cohort of adult LVAD recipients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009327: HVAD\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009112, HMII\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009142, HM3\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200973). Baseline characteristics and perioperative variables were recorded. Overall survival was analyzed using Kaplan\u2013Meier and Cox proportional hazards models with HM3 as reference. Hemocompatibility\u2010related adverse events (HRAE; pump thrombosis, ischemic stroke, major bleeding) were assessed with cumulative incidence functions (Aalen\u2013Johansen) and Fine\u2013Gray competing\u2010risk regression with death as a competing event; the hemocompatibility score (HCS) summarized event burden over follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HM3 demonstrated superior long\u2010term survival compared with both HMII and HVAD in Kaplan\u2013Meier analyses (log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001); this advantage persisted in multivariable Cox models. HRAE\u2010free survival was also higher with HM3 on competing\u2010risk analysis, driven by substantially lower pump thrombosis and fewer ischemic strokes relative to HMII and HVAD. Bleeding burden did not differ materially between devices, consistent with a class effect of continuous\u2010flow support. LDH\u2010based hemolysis markers and HCS distributions further favored HM3. Perioperative course and general postoperative complications were otherwise broadly comparable across devices.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this real\u2010world, multicenter cohort, HM3 was associated with better overall survival and a lower thromboembolic burden than HMII and HVAD, while bleeding risk remained similar. These findings support preferential selection of HM3 when device choice is feasible, and emphasize the need for targeted strategies to mitigate hemostatic complications across all LVADs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.70086","type":"journal-article","created":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T16:44:43Z","timestamp":1767545083000},"page":"580-589","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hemocompatibility and Long\u2010Term Outcomes in\n                    <scp>H<\/scp>\n                    eart\n                    <scp>W<\/scp>\n                    are Versus\n                    <scp>H<\/scp>\n                    eart\n                    <scp>M<\/scp>\n                    ate\n                    <scp>II<\/scp>\n                    Versus\n                    <scp>H<\/scp>\n                    eart\n                    <scp>M<\/scp>\n                    ate 3: Multicenter Real\u2010World Cohort"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0593-5124","authenticated-orcid":false,"given":"Hamza H. H.","family":"Ben Nasir","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Operative Intensive Care Klinikum Links der Weser gGmbH  Bremen Germany"},{"name":"Department of Cardiac Surgery RWTH University Hospital  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed F. A.","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery RWTH University Hospital  Aachen Germany"},{"name":"Department of Cardiothoracic Surgery, Faculty of Medicine Qena University  Qena Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Allham","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Heart Centre Dresden Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2048-1049","authenticated-orcid":false,"given":"Alish","family":"Kolashov","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Heart Centre Trier Barmherzigen Brueder Hospital  Trier Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0565-7795","authenticated-orcid":false,"given":"Yusuf","family":"Shieba","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Faculty of Medicine Qena University  Qena Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lachmandath","family":"Tewarie","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery RWTH University Hospital  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4992-818X","authenticated-orcid":false,"given":"Bernd","family":"Panholzer","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery University Hospital Schleswig\u2010Holstein  Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9330-142X","authenticated-orcid":false,"given":"Ajay","family":"Moza","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery RWTH University Hospital  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assad","family":"Haneya","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Heart Centre Trier Barmherzigen Brueder Hospital  Trier Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2243-8743","authenticated-orcid":false,"given":"Rashad","family":"Zayat","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery RWTH University Hospital  Aachen 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