{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T05:30:17Z","timestamp":1786512617613,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute respiratory failure after cardiac surgery is an uncommon complication, affecting morbidity and mortality. In these patients, respiratory extracorporeal membrane oxygenation (ECMO) support may be beneficial, as it may help reduce pulmonary vasoconstriction and the impact of respiratory pressures on the heart. Nevertheless, literature reports of postcardiotomy veno\u2010venous (V\u2010V) ECMO use are sporadic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective, multicenter cohort study analyzes data from the PELS\u20101 registry, focusing on adult patients who required V\u2010V ECMO following cardiac surgery. PELS\u20101 was conducted across 34 cardiac surgery centers in 16 countries from 2000 to 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 24 patients who received V\u2010V ECMO over a total of 2163 patients requiring postocardiotomy extracorporeal support (1.1%). The median age was 64[50\u201369] years, and 16\/24 (67%) were male. Median Euroscore II was 6.2[3.1\u201319.6]. Most patients required prolonged cardiopulmonary bypass (CPB) time (208[110\u2013350] min). V\u2010V ECMO was initiated in the ICU in 21 patients (87.5%) after a median of 5 [2\u201312] days postoperatively. ECMO support rapidly normalized gas exchange and lactate levels. However, complications were frequent: bleeding (10\/22, 45.5%), acute kidney injury (10\/24, 41.7%), pneumonia (10\/24, 41.7%), and arrhythmias (7\/24, 29.2%) were the most frequent ones. In\u2010hospital mortality was high, with only 21.7% discharged alive. One\u2010year survival was 12.5%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Reported outcomes of patients receiving V\u2010V ECMO after cardiac surgery are poor, despite effective correction of gas exchange. Early recognition of isolated respiratory failure and careful patient selection should be promoted. Further research is needed to optimize management in this high\u2010risk population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.70093","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T03:50:42Z","timestamp":1768189842000},"page":"745-754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes in Patients Requiring Veno\u2010Venous Extracorporeal Membrane Oxygenation After Cardiac Surgery: An Analysis From the PELS\u20101 Study"],"prefix":"10.1111","volume":"50","author":[{"given":"Pasquale","family":"Nardelli","sequence":"first","affiliation":[{"name":"Cardiovascular Research Institute Maastricht (CARIM) Maastricht University  Maastricht the Netherlands"},{"name":"Cardiac Critical Care Unit IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Mariani","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute Maastricht (CARIM) Maastricht University  Maastricht the Netherlands"},{"name":"Cardiac Surgery Unit Fondazione IRCCS San Gerardo dei Tintori  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elena","family":"De Piero","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute Maastricht (CARIM) Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bas C. T.","family":"van Bussel","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute Maastricht (CARIM) Maastricht University  Maastricht the Netherlands"},{"name":"Department of Intensive Care Medicine Maastricht University Medical Center  Maastricht the Netherlands"},{"name":"Care and Public Health Research Institute Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2611-5626","authenticated-orcid":false,"given":"Michele","family":"Di Mauro","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute Maastricht (CARIM) Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann\u2010Kristin","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diyar","family":"Saeed","sequence":"additional","affiliation":[{"name":"Heart Center Niederrhein Helios Hospital Krefeld  Krefeld Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Pozzi","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Louis Pradel Cardiologic Hospital  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Botta","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo","family":"Boeken","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical Faculty Heinrich Heine University  Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7854-2211","authenticated-orcid":false,"given":"Robertas","family":"Samalavicius","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Centre of Anesthesia, Intensive Care and Pain Management Vilnius University Hospital Santariskiu Klinikos  Vilnius Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Bounader","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic and Vascular Surgery Pontchaillou University Hospital  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Hou","sequence":"additional","affiliation":[{"name":"Center for Cardiac Intensive Care, Beijing Institute of Heart, Lung, and Blood Vessels Diseases, Beijing Anzhen Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen J. 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University of Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Diaz","sequence":"additional","affiliation":[{"name":"ECMO Unit, Departamento de Anestesia Cl\u00ednica Las Condes  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u2010wen","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery Memorial Healthcare System  Hollywood Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae\u2010Seung","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Korea University Anam Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Belohlavek","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, Cardiovascular Medicine General Teaching Hospital and 1st Faculty of Medicine Charles University in Prague  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vin","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"Intensive Care Unit The Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Ospedale del Cuore Fondazione Toscana \u201cG Monasterio\u201d  Massa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Pettinari","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Ziekenhuis Oost\u2010Limburg  Genk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5120-5802","authenticated-orcid":false,"given":"Alessandro","family":"Barbone","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit IRCCS Humanitas Research Hospital  Rozzano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 P.","family":"Garcia","sequence":"additional","affiliation":[{"name":"IU Health Advanced Heart &amp; Lung Care Indiana University Methodist Hospital  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Shekar","sequence":"additional","affiliation":[{"name":"Adult Intensive Care Services, The Prince Charles Hospital and the University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn","family":"Whitman","sequence":"additional","affiliation":[{"name":"Cardiac Intensive Care Unit Johns Hopkins Hospital  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Lorusso","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute Maastricht (CARIM) Maastricht University  Maastricht the Netherlands"},{"name":"Cardio\u2010Thoracic Surgery Department Maastricht University Medical Centre  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"PELS Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,11]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"275","article-title":"Prolonged Mechanical Ventilation After Cardiac Surgery: Predictors and Impact on Outcome","volume":"51","author":"Benedetto U.","year":"2017","journal-title":"European Journal of Cardio\u2010Thoracic Surgery"},{"key":"e_1_2_10_3_1","first-page":"497","article-title":"Acute Respiratory Failure After Cardiac Surgery: Pathophysiology and Clinical Management","volume":"45","author":"Lazzeri C.","year":"2016","journal-title":"Heart & Lung"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e31818d8b92"},{"key":"e_1_2_10_5_1","first-page":"976","article-title":"Right Ventricular Dysfunction and Mortality After Cardiac Surgery","volume":"43","author":"Harhay M. 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