{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T06:06:06Z","timestamp":1780553166145,"version":"3.54.1"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Gastrointestinal bleeding is a common complication in continuous\u2010flow left ventricular assist device (CF\u2010LVAD) patients. Managing gastrointestinal bleeding often requires reducing or stopping anticoagulation, potentially increasing the risk of thromboembolic events. This study aimed to evaluate thromboembolic events in CF\u2010LVAD recipients.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We analyzed data from our institutional Intermacs database from January 2008 to December 2023. The cohort included both primary implants and pump exchanges. Thromboembolic events were defined as ischemic stroke, transient ischemic attack, or pump thrombosis (excluding pre\u2010gastrointestinal bleeding ones). Multivariable logistic regression was used to evaluate gastrointestinal bleeding as a risk factor for thromboembolic events.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 1075 CF\u2010LVAD implants, the median age was 58.5\u2009years (IQR 50.0\u201365.7), with 79.8% male. Most patients (80.6%) had an Intermacs profile \u2264\u20093. Gastrointestinal bleeding occurred in 32.2%, among whom thromboembolic events occurred in 26.3%. Median time from gastrointestinal bleeding to thromboembolic events was 12.7\u2009months (IQR 4.0\u201324.5). Gastrointestinal bleeding increased the risk of thromboembolic events by 52% (OR 1.52,\n p<\/jats:italic>\n \u2009=\u20090.018). Additionally, among all CF\u2010LVAD implants, patients aged \u2265\u200950\u2009years had a 66% higher risk (\n p<\/jats:italic>\n \u2009=\u20090.024), and Black patients had twice the risk compared to non\u2010Black patients (\n p<\/jats:italic>\n \u2009<\u20090.001). Axial\u2010flow (OR 3.9) and partial magnetically levitated centrifugal\u2010flow LVADs (OR 3.5) were associated with significantly higher thromboembolic risk compared to fully magnetically levitated centrifugal\u2010flow devices (\n p<\/jats:italic>\n \u2009<\u20090.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Thromboembolic events remain a major risk in CF\u2010LVAD patients. Gastrointestinal bleeding significantly increases thromboembolic risk. Higher risk was also seen in patients aged \u2265\u200950\u2009years, Black patients, and those with older CF\u2010LVAD models.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/aor.70101","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T03:48:43Z","timestamp":1769053723000},"page":"886-890","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Does Gastrointestinal Bleeding Increase the Risk of Thromboembolic Events in Patients Supported With\n CF<\/scp>\n \u2010\n LVADs<\/scp>\n ?"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2608-0152","authenticated-orcid":false,"given":"Anh","family":"Nguyen","sequence":"first","affiliation":[{"name":"Division of Cardiothoracic Transplantation and Circulatory Support, Department of Surgery Baylor College of Medicine Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Shafii","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Transplantation and Circulatory Support, Department of Surgery Baylor College of Medicine Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Loor","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Transplantation and Circulatory Support, Department of Surgery Baylor College of Medicine Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhasis","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Division of Trauma and Acute Care Surgery, Department of Surgery Baylor College of Medicine Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Civitello","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Baylor College of Medicine Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. Howard","family":"Frazier","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Transplantation and Circulatory Support, Department of Surgery Baylor College of Medicine Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Liao","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Transplantation and Circulatory Support, Department of Surgery Baylor College of Medicine Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.01.017"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.14432"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001486"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.5114\/pg.2023.134394"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/AOR.14235"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.HEALUN.2013.07.020"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/AOR.13751"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.02.004"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/1010\u20107940(90)90002\u2010H"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ATHORACSUR.2009.06.095"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2016"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.70101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aor.70101","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.70101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:17:19Z","timestamp":1780550239000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.70101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,21]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/aor.70101"],"URL":"https:\/\/doi.org\/10.1111\/aor.70101","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,21]]},"assertion":[{"value":"2025-12-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}