{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T06:06:06Z","timestamp":1780553166091,"version":"3.54.1"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020219","name":"Research Institute for Science and Technology, Tokyo Denki University","doi-asserted-by":"publisher","award":["Q18L\u201003"],"award-info":[{"award-number":["Q18L\u201003"]}],"id":[{"id":"10.13039\/100020219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Cardiac operations with cardiopulmonary bypass (CPB) trigger a systemic inflammatory response. To understand the underlying mechanisms behind the biological reactions during CPB, rat models that mimic clinical CPB have been developed. Previously, a rat CPB model incorporating an intraluminal flow oxygenator was employed to accommodate the limited blood volume of rats. This study aimed to evaluate a rat CPB model incorporating an extraluminal flow oxygenator.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The effective membrane area and priming volume of the extraluminal flow oxygenator were 0.0236\u2009m\n 2<\/jats:sup>\n and 3.0\u2009mL, respectively. Rats were divided into three groups: (i) SHAM group (surgical preparation only); (ii) CPB with intraluminal flow oxygenator group (CPB Int\u2010oxy); and (iii) CPB with extraluminal flow oxygenator group (CPB Ext\u2010oxy). Blood samples were collected before and at 60 and 120\u2009min after CPB initiation. Hemodynamics, blood gases, blood cell counts (RBC, WBC, PLT), and inflammatory responses (IL\u20106, IL\u201010, TNF\u2010\u03b1) were measured.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Each CPB group maintained an arterial pressure and Hb at approximately 75\u2009mmHg and 9.5%, respectively, without blood transfusion, and an oxygenation and carbon dioxide removal from the blood were confirmed. In the CPB Ext\u2010oxy group, PLT counts were significantly preserved at 60 and 120\u2009min after the start of circulation compared with those in the CPB Int\u2010oxy group. However, no significant differences in IL\u20106, IL\u201010, or TNF\u2010\u03b1 levels were observed between the CPB groups.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Incorporating the extraluminal flow oxygenator into a rat CPB model enables the simulation of CPB conditions that closely mimic those encountered in clinical CPB.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/aor.70105","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T03:05:46Z","timestamp":1770865546000},"page":"825-830","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of a Rat Cardiopulmonary Bypass Model Using an Extraluminal Flow Oxygenator"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1077-7054","authenticated-orcid":false,"given":"Hirohito","family":"Sumikura","sequence":"first","affiliation":[{"name":"Department of Science and Engineering, School of Science and Engineering Tokyo Denki University Hatoyama Japan"},{"name":"Graduate School of Science and Engineering Graduate School of Tokyo Denki University Hatoyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Clinical Engineering and Medical Technology, Faculty of Medical Technology Niigata University of Health and Welfare Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Uchiyama","sequence":"additional","affiliation":[{"name":"Graduate School of Science and Engineering Graduate School of Tokyo Denki University Hatoyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Homma","sequence":"additional","affiliation":[{"name":"Department of Science and Engineering, School of Science and Engineering Tokyo Denki University Hatoyama Japan"},{"name":"Graduate School of Science and Engineering Graduate School of Tokyo Denki University Hatoyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/ija.IJA_379_17"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2008.08.009"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(01)01099-5"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10047-014-0804-y"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2012.01535.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.5136\/lifesupport.30.96"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2004.08.007"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/026765910101600111"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-007-0668-x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-020-01581-3"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4007092"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000347"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.70105","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aor.70105","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.70105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:17:30Z","timestamp":1780550250000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.70105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,11]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/aor.70105"],"URL":"https:\/\/doi.org\/10.1111\/aor.70105","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,11]]},"assertion":[{"value":"2025-10-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}