{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T06:02:51Z","timestamp":1780552971893,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008084","name":"Neurof\u00f6rbundet","doi-asserted-by":"publisher","award":["F2024\u20100021"],"award-info":[{"award-number":["F2024\u20100021"]}],"id":[{"id":"10.13039\/501100008084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008084","name":"Neurof\u00f6rbundet","doi-asserted-by":"publisher","award":["FO2019\u20100006"],"award-info":[{"award-number":["FO2019\u20100006"]}],"id":[{"id":"10.13039\/501100008084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007436","name":"Erling-Perssons Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007436","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction<\/jats:title>\n Brain infarction (BI) is a severe complication of extracorporeal membrane oxygenation (ECMO) with high morbidity and mortality. We aimed to determine the incidence of BI and identify predictors in pediatric patients receiving ECMO.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We performed a retrospective single\u2010center cohort study including patients aged 29\u2009days to <\u200918\u2009years who underwent ECMO treatment at a tertiary center between January 2010 and October 2023. The primary outcome was BI during ECMO. Predictors of BI were analyzed using logistic regression.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 179 included patients, BI was diagnosed in 51 (28%). Multivariable logistic regression identified venoarterial (VA) ECMO (OR 3.82, 95% CI 1.45\u201310.08;\n p<\/jats:italic>\n \u2009=\u20090.007) and higher pre\u2010ECMO arterial lactate (per mmol\/L increase, OR 1.11, 95% CI 1.02\u20131.20;\n p<\/jats:italic>\n \u2009=\u20090.01) as independent predictors of BI. The 30\u2010day mortality was 67% among patients with BI compared with 15% among those without BI (\n p<\/jats:italic>\n \u2009<\u20090.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Brain infarction was more common than in most prior reports and was associated with high short\u2010term mortality. VA ECMO mode, compared with venovenous ECMO, and higher pre\u2010ECMO arterial lactate were independent predictors of BI. These findings support enhanced, standardized neurological monitoring and a liberal early brain CT strategy in pediatric ECMO patients, particularly those supported with VA ECMO.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/aor.70115","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T01:39:51Z","timestamp":1774661991000},"page":"909-916","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of Brain Infarction in Pediatric Patients During Extracorporeal Membrane Oxygenation"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7536-3795","authenticated-orcid":false,"given":"Riccardo","family":"Iacobelli","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology Karolinska Institutet Stockholm Sweden"},{"name":"ECMO Centre Karolinska, Intensive Care and Transport, Pediatric Perioperative Medicine and Intensive Care Karolinska University Hospital Stockholm Sweden"},{"name":"Department of Internal Medicine Visby Hospital Visby Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Fux","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Karolinska Institutet Stockholm Sweden"},{"name":"Department of Perioperative Medicine and Intensive Care Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Wood Schalling","sequence":"additional","affiliation":[{"name":"ECMO Centre Karolinska, Intensive Care and Transport, Pediatric Perioperative Medicine and Intensive Care Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Kopfer","sequence":"additional","affiliation":[{"name":"ECMO Centre Karolinska, Intensive Care and Transport, Pediatric Perioperative Medicine and Intensive Care Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Berner","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Karolinska Institutet Stockholm Sweden"},{"name":"ECMO Centre Karolinska, Intensive Care and Transport, Pediatric Perioperative Medicine and Intensive Care Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Fletcher\u2010Sandersj\u00f6\u00f6","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden"},{"name":"Department of Neurosurgery Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars Mikael","family":"Broman","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Karolinska Institutet Stockholm Sweden"},{"name":"ECMO Centre Karolinska, Intensive Care and Transport, Pediatric Perioperative Medicine and Intensive Care Karolinska University Hospital Stockholm 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