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The eyeball, especially its neural components, undergoes nearly immediate degeneration unless adequately preserved. Oxygenated subnormothermic machine perfusion (SNMP) has emerged as a promising alternative to static cold storage (SCS), offering potential benefits for graft preservation and reconditioning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      WETs were procured from adult swine following a mean\n                      <jats:italic>164.7<\/jats:italic>\n                      \u2009\u00b1\u2009\n                      <jats:italic>6.1\u2009min<\/jats:italic>\n                      of warm ischemia and perfused ex\u00a0vivo using a Steen+ solution administered at room temperature for 18\u2009h. Perfusion parameters, weight gain, and metabolic markers were recorded throughout the perfusion. Histological analysis and an atropine mydriasis test were performed to assess WET integrity and function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Following an initial phase of metabolic clearance and weight loss, perfusion parameters stabilized, and final weight gain (\n                      <jats:italic>t<\/jats:italic>\n                      \u2009=\u200918\u2009h) remained below 10%. Histological evaluation confirmed tissue preservation, and iris function was restored upon atropine administration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study represents the first application of SNMP to a whole eye composite transplant model, demonstrating promising outcomes in this large animal model and supporting SNMP as a potential alternative to SCS for WET.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.70118","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T03:29:22Z","timestamp":1773977362000},"page":"764-772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of a Swine Whole Eye Transplant Ex\u00a0Vivo Perfusion Protocol"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8927-3707","authenticated-orcid":false,"given":"Ha\u00efzam","family":"Oubari","sequence":"first","affiliation":[{"name":"Center for Engineering in Medicine and Surgery Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"},{"name":"Shriners Children's Boston  Boston Massachusetts USA"},{"name":"Plastic Surgery Research Laboratory, Department of Plastic and Reconstructive Surgery Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Plastic, Reconstructive and Aesthetic Surgery Hospices Civils de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucile","family":"Cabanel","sequence":"additional","affiliation":[{"name":"Center for Engineering in Medicine and Surgery Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"},{"name":"Shriners Children's Boston 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A.","family":"Randolph","sequence":"additional","affiliation":[{"name":"Shriners Children's Boston  Boston Massachusetts USA"},{"name":"Plastic Surgery Research Laboratory, Department of Plastic and Reconstructive Surgery Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basak","family":"Uygun","sequence":"additional","affiliation":[{"name":"Center for Engineering in Medicine and Surgery Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"},{"name":"Shriners Children's Boston  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Korkut","family":"Uygun","sequence":"additional","affiliation":[{"name":"Center for Engineering in Medicine and Surgery Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"},{"name":"Shriners Children's Boston  Boston Massachusetts 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