{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T09:05:47Z","timestamp":1784883947314,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["851368"],"award-info":[{"award-number":["851368"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006975","name":"Indiana Clinical and Translational Sciences Institute","doi-asserted-by":"publisher","award":["UM1TR004402"],"award-info":[{"award-number":["UM1TR004402"]}],"id":[{"id":"10.13039\/100006975","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>With increasing interest in renal normothermic machine perfusion (NMP), a deeper understanding of ex\u00a0vivo renal physiology is essential to establish NMP as a robust pre\u2010transplant assessment platform. This study utilized magnetic resonance imaging (MRI) to compare in\u00a0vivo renal physiology in healthy volunteers with ex\u00a0vivo renal function of human donor kidneys during NMP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multiparametric MRI maps assessing water diffusion, oxygenation, tissue characteristics, and perfusion were obtained from 11 healthy volunteers to define an in\u00a0vivo renal reference frame. For ex\u00a0vivo evaluation, 25 discarded human donor kidneys underwent 4\u2009h of oxygenated hypothermic machine perfusion, followed by 6\u2009h of NMP in an MRI\u2010compatible setup. The kidneys were assessed hourly using comparable MRI modalities as in\u00a0vivo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ex vivo renal physiology was substantially different from in\u00a0vivo physiology in terms of MRI\u2010based diffusion patterns, oxygenation, tissue characteristics, and tissue perfusion. Most MRI measurements did not correlate well with conventional parameters such as flow, renal function, and injury markers during NMP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings highlight distinct differences between in\u00a0vivo and ex\u00a0vivo MRI\u2010based renal characteristics in a human cohort, suggesting that parameters beyond conventional in\u00a0vivo functional markers may warrant consideration when evaluating organ viability during NMP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.70142","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:27:14Z","timestamp":1777350434000},"page":"1037-1051","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Magnetic Resonance Imaging Evaluation of Functional Differences Between In\u00a0Vivo Human Kidneys and Discarded Human Kidneys During Ex\u00a0Vivo Normothermic Machine Perfusion"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4860-5984","authenticated-orcid":false,"given":"Tim L.","family":"Hamelink","sequence":"first","affiliation":[{"name":"Department of Surgery, Organ Donation and Transplantation University Medical Center Groningen, University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8214-2288","authenticated-orcid":false,"given":"Chris L.","family":"Jaynes","sequence":"additional","affiliation":[{"name":"Department of Surgery, Organ Donation and Transplantation University Medical Center Groningen, University of Groningen  Groningen the Netherlands"},{"name":"34 Lives, Public Benefit Corporation  West\u2010Lafayette Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0450-7581","authenticated-orcid":false,"given":"L. Annick","family":"van Furth","sequence":"additional","affiliation":[{"name":"Department of Surgery, Organ Donation and Transplantation University Medical Center Groningen, University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5152-7660","authenticated-orcid":false,"given":"Johannes","family":"Castelein","sequence":"additional","affiliation":[{"name":"Department of Radiology University Medical Center Groningen  Groningen the Netherlands"},{"name":"Department of Biomedical Sciences Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1050-5504","authenticated-orcid":false,"given":"Nathan","family":"Ooms","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Purdue University  West\u2010Lafayette Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6931-2825","authenticated-orcid":false,"given":"Veerle A.","family":"Lantinga","sequence":"additional","affiliation":[{"name":"Department of Surgery, Organ Donation and Transplantation University Medical Center Groningen, University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5658-6838","authenticated-orcid":false,"given":"Baran","family":"Ogurlu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Organ Donation and Transplantation University Medical Center Groningen, University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5748-0414","authenticated-orcid":false,"given":"Xiaopeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Purdue University  West\u2010Lafayette Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1852-7110","authenticated-orcid":false,"given":"Ulrike","family":"Dydak","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Purdue University  West\u2010Lafayette Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5036-2999","authenticated-orcid":false,"given":"Henri G. 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