{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T05:41:33Z","timestamp":1786254093336,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004955","name":"\u00d6sterreichische Forschungsf\u00f6rderungsgesellschaft","doi-asserted-by":"publisher","award":["FO999891239"],"award-info":[{"award-number":["FO999891239"]}],"id":[{"id":"10.13039\/501100004955","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hemocompatibility\u2010related adverse events still limit the broader adoption of rotodynamic blood pumps. This study aims to evaluate the potential of a multistage pump design to enhance hemocompatibility in left ventricular assist devices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Computational fluid dynamic simulations were utilized to compare the pump performance and hemocompatibility of a Two\u2010Stage Pump to two equivalent single\u2010stage devices, designed for identical operating conditions. One single\u2010stage design features equal impeller and volute dimensions; the other, equal specific speed and specific diameter. Our simulation setup was validated against in\u00a0vitro experiments of the pump performance of the Two\u2010Stage Pump.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The Two\u2010Stage Pump achieved a substantial reduction in circumferential velocity (24% and 29% reduction). Although the two\u2010stage configuration thereby effectively reduces shear stress, it simultaneously translates to a longer residence time due to the larger priming volume. However, because the numerical blood damage estimation weighs shear stress exponentially more than residence time, the beneficial effect of reduced shear stress partially compensates for the longer residence time. As a result, the Two\u2010Stage Pump demonstrates a lower hemolysis index (12% and 14% reduction) compared to both single\u2010stage designs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our comparative study demonstrates that the two\u2010stage concept offers favorable hemolysis measures compared to single\u2010stage designs, as the reduction in peak shear stresses outweighs the disadvantage associated with prolonged residence time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.70152","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:00:21Z","timestamp":1777690821000},"page":"1125-1135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of a Miniaturized Implantable Two\u2010Stage Rotodynamic Blood Pump to Equivalent Single\u2010Stage Concepts"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3045-8583","authenticated-orcid":false,"given":"Sarah","family":"Linnemeier","sequence":"first","affiliation":[{"name":"Department of Cardiac and Thoracic Aortic Surgery Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bente","family":"Thamsen","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Thoracic Aortic Surgery Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Maric","sequence":"additional","affiliation":[{"name":"Institute of Energy Systems and Thermodynamics Vienna University of Technology  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Semlitsch","sequence":"additional","affiliation":[{"name":"Institute of Energy Systems and Thermodynamics Vienna University of Technology  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Torner","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Thoracic Aortic Surgery Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Zimpfer","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Thoracic Aortic Surgery Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Granegger","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Thoracic Aortic Surgery Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,1]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2333"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/children8050322"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2017.07.005"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2020.12.038"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.028303"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-12824-0"},{"key":"e_1_2_12_8_1","unstructured":"B. K.Thamsen \u201cA Two\u2010Stage Rotary Blood Pump Design to Reduce Blood Trauma \u201dDissertation Technische Universit\u00e4t Berlin Berlin 2016."},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2025.3553731"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.5301\/ijao.5000482"},{"key":"e_1_2_12_11_1","volume-title":"Fluid Mechanics and Thermodynamics of Turbomachinery","author":"Dixon S. L.","year":"2014"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MAT.0000104817.39941.9C"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e318155741d"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181e8adee"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/039139889001300507"},{"key":"e_1_2_12_16_1","volume-title":"Simcenter STAR\u2010CCM+ User Guide 2310","author":"Siemens Digital Industries Software","year":"2023"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.2514\/3.12149"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4007092"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2022.3146135"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12542"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.13346"},{"key":"e_1_2_12_22_1","unstructured":"L.E\u00e7a S. L.Toxopeus andM.Kerkvliet \u201cProcedures for the Estimation of Numerical Uncertainties in the Simulation of Steady and Unsteady Flows \u201dIST New Delhi Report No. M\u20108."},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1122\/1.549276"},{"key":"e_1_2_12_24_1","unstructured":"K.Yasuda \u201cInvestigation of the Analogies Between Viscometric and Linear Viscoelastic Properties of Polystyrene Fluids \u201dThesis Massachusetts Institute of Technology 1979 https:\/\/dspace.mit.edu\/handle\/1721.1\/16043."},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.2780"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2010.10.014"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2019.06.017"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525\u20101594.2004.00026.x"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3233\/BIR\u20101980\u2010171\u2010205"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525\u20101594.2003.00026.x"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.14875"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010020\u201002599\u2010z"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/adts.202200117"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439\u2010017\u20101951\u20100"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4005765"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000002300"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e318254833b"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.70152","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aor.70152","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.70152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T04:42:56Z","timestamp":1786250576000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.70152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,1]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/aor.70152"],"URL":"https:\/\/doi.org\/10.1111\/aor.70152","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,1]]},"assertion":[{"value":"2025-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}