{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:35:52Z","timestamp":1790922952763,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2R44HL144214"],"award-info":[{"award-number":["2R44HL144214"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inspired Therapeutics is advancing the development of the next generation of the NeoMate mechanical circulatory support (MCS) system for neonate and infant heart failure (HF) populations. The NeoMate system includes a low\u2010cost magnetically\u2010actuated paracorporeal centrifugal pump with an integrated, reusable motor and controller. This design iteration features a compact size (37\u2009mm diameter), small prime volume (10\u2009mL), and redesigned rotor and flow path. We present experimental data from computational fluid dynamics (CFD), mock loops, and acute animals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      CFD models were used to improve pump design (wall shear stress, hemolysis index) and motor performance (torque, power, efficiency). Static mock loops (3.5\u2009cP) were performed to evaluate hydrodynamics over a range of loads (0\u2013300\u2009mmHg) at 500\u20135500\u2009rpm (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092 pumps tested, 24Fr inflow and 16Fr outflow cannula). A dynamic mock loop (3.5\u2009cP) was tuned to HF, with the pump integrated LV apex\u2010to\u2010aorta and data collected from 0 to 5500\u2009rpm. Two acute sheep studies were performed with each pump implanted paracorporeally: one LV apex\u2010to\u2010aorta (24Fr inflow, 16Fr outflow) and the other via the jugular vein (28Fr dual\u2010lumen cannula).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CFD pump and motor performance and hemolysis index metrics were achieved exceeding design criteria (2.5\u2009L\/min, 150\u2009mmHg) in static (2.5\u2009L\/min flow, 250\u2009mmHg pressure), dynamic (2.8\u2009L\/min flow), and animals (3.1\u2009L\/min flow, 60\u2009mmHg aortic pressure, plasma free hemoglobin &lt;\u200920\u2009mg\/dL) at 5500\u2009rpm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The next generation NeoMate pumps demonstrated favorable hydrodynamic, hemodynamic, and blood trauma performance, showing promising progress toward this technology to serve as a versatile therapy for neonates and infants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.70155","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:50:11Z","timestamp":1777431011000},"page":"1182-1189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Feasibility Testing of the 2nd Generation Inspired Therapeutics\n                    <scp>NeoMate<\/scp>\n                    System for Paracorporeal Support of Neonates and Infants in Heart Failure"],"prefix":"10.1111","volume":"50","author":[{"given":"Gretel","family":"Monreal","sequence":"first","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery University of Louisville  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8348-6127","authenticated-orcid":false,"given":"Steven C.","family":"Koenig","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery University of Louisville  Louisville Kentucky USA"},{"name":"Department of Bioengineering University of Louisville  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Kelley","sequence":"additional","affiliation":[{"name":"Inspired Therapeutics LLC  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua G.","family":"Crane","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery University of Louisville  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle R.","family":"Lytle","sequence":"additional","affiliation":[{"name":"School of Medicine University of Louisville  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiapeng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine University of Louisville  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Slaughter","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery University of Louisville  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G.","family":"White","sequence":"additional","affiliation":[{"name":"Rand Simulation  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Tamez","sequence":"additional","affiliation":[{"name":"Inspired Therapeutics LLC  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Kelley","sequence":"additional","affiliation":[{"name":"Inspired Therapeutics LLC  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhlto.2025.100331"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2025.06.003"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.03.336"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001245"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2023.11.035"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2024.12.020"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001323"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13239\u2010021\u201000578\u2010z"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13239\u2010021\u201000602\u20102"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0266822"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e318254833b"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001887"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13239\u2010024\u201000748\u20109"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13239\u2010024\u201000743\u20100"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.70051"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2025.06.018"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.70155","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aor.70155","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.70155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T04:43:33Z","timestamp":1786250613000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.70155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/aor.70155"],"URL":"https:\/\/doi.org\/10.1111\/aor.70155","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]},"assertion":[{"value":"2026-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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