{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T17:40:54Z","timestamp":1788630054184,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL118372"],"award-info":[{"award-number":["R01HL118372"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL162940"],"award-info":[{"award-number":["R01HL162940"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL171120"],"award-info":[{"award-number":["R01HL171120"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mechanical circulatory support (MCS) has emerged as a life\u2010saving intervention and may be a potential alternative to organ transplant for patients with end\u2010stage heart failure. The Heartmate III (HM3) left ventricular assist device (LVAD) is a magnetically levitated centrifugal pump and the most advanced LVAD on the current MCS market. The BrioVAD is a newly developed LVAD featuring a fully magnetically suspended blood pump and has recently been approved by the FDA for the INNOVATE trial in the US. However, device\u2010related complications, which are highly related to blood damage by the pump, remain a major concern for patients with MCS. This study aimed to compare device\u2010induced blood damage by the HM3 and BrioVAD pumps in\u00a0vitro in a circulatory loop.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The device\u2010assisted circulatory loop was filled with fresh, healthy human blood. Both pumps were operated under the same clinically relevant condition, i.e., a blood flow rate of 4.5\u2009L\/min and an afterload pressure head of 75\u2009mmHg, for 4\u2009h. Hourly blood samples were collected to assess device\u2010induced damage to blood components, including red blood cells, platelets, neutrophils, and von Willebrand factor (VWF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both pumps had comparable impacts on blood components, with no statistically significant difference between them in all the measured parameters (except one neutrophil activation marker). After the four hours of device\u2010assisted circulation, both pumps caused minimal hemolysis and moderate platelet damage but had significant impacts on VWF and neutrophils.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provides a comprehensive comparative in\u00a0vitro analysis of blood damage caused by the HM3 and BrioVAD pumps under a clinically relevant condition. The results provide valuable insight into the potential implications for clinical use of the two devices and guidance for the design of new LVADs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.70166","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:48:42Z","timestamp":1778644122000},"page":"1295-1304","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Device\u2010Induced Blood Damage in Pump\u2010Assisted Circulation: A Comparative Study of\n                    <scp>HeartMate III<\/scp>\n                    and\n                    <scp>BrioVAD<\/scp>\n                    Pumps"],"prefix":"10.1111","volume":"50","author":[{"given":"Wenji","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Surgery University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiersten P.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Vandenberge","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anik","family":"Tarafder","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy","family":"Perez","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartley P.","family":"Griffith","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab368"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2021.05.009"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2011.04.010"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.027251"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.035566"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000388"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000987"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.16197"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2021.01.001"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2018.01.083"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1610426"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2024.05.004"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2025.03.001"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.09.083"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10237\u2010024\u201001855\u20101"},{"key":"e_1_2_14_17_1","doi-asserted-by":"crossref","unstructured":"P.Wu W.\u2010J.Xiang K.\u2010J.Zhang andG.\u2010T.Du Investigation of turbulent flow field in maglev centrifugal blood pumps of CH\u2010VAD and Heartmate III using large\u2010eddy simulation 2023.","DOI":"10.21203\/rs.3.rs-3705271\/v1"},{"key":"e_1_2_14_18_1","volume-title":"ASTM F1841\u201019 E1 Standard Practice for Assessment of Hemolysis in Continuous Flow Blood Pumps","author":"ASTM 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