{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:01:59Z","timestamp":1790694119955,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T00:00:00Z","timestamp":1780790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T00:00:00Z","timestamp":1780790400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["10.55776\/PIN5467323"],"award-info":[{"award-number":["10.55776\/PIN5467323"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Rotodynamic blood pumps (RBPs) must operate reliably across a wide range of clinical conditions, including off\u2010design operating regimes. Although blade shape is known to influence off\u2010design performance in conventional turbopumps, its impact on hydraulic performance and hemocompatibility in RBPs has not been systematically investigated. This study combines in silico and in\u00a0vitro analyses to assess the effects of leading\u2010edge geometry and blade thickness on performance (pressure head\u2010flow rate characteristics, efficiencies) and hemocompatibility (damage index, DI) across multiple RBPs and operating conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Three representative RBPs, a cavopulmonary assist device, the CentriMag RBP, and a novel ventricular assist device, were investigated. Semi\u2010circular, elliptical, and wedge\u2010shaped leading edges were implemented, whereas three blade thickness configurations were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Variations in leading\u2010edge geometry resulted in minor differences in performance (&lt;\u20093 percent in efficiency) and hemocompatibility (&lt;\u20093% DI) across all devices and operating conditions. In contrast, blade thickness had a pronounced effect on performance under overload off\u2010design operation, with thinner blades improving efficiency by up to 22%, while exhibiting only limited changes in hemocompatibility\u2010related metrics (&lt;\u20097% DI). The observed efficiency differences were primarily attributed to decreased friction losses caused by less channel blockage with thinner impeller blades.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, impeller blade shape plays a secondary role in hemocompatibility within the investigated pump types and operating conditions. This finding suggests that leading\u2010edge optimization may be deprioritized relative to other hemocompatibility\u2010critical geometry parameters in RBP design. Blade thickness, however, may lead to unfavorable channel blockage effects and therefore needs to be optimized with respect to manufacturing constraints and hydraulic performance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.70178","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T02:29:08Z","timestamp":1780885748000},"page":"1360-1371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Shaping the Flow: Impact of Blade Shape on Performance and Hemocompatibility in Rotodynamic Blood Pumps"],"prefix":"10.1111","volume":"50","author":[{"given":"Benjamin","family":"Torner","sequence":"first","affiliation":[{"name":"Department of Cardiac and Thoracic Aortic Surgery Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Klocker","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Thoracic Aortic Surgery Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niccol\u00f2","family":"Crescenti","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Thoracic Aortic Surgery Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo J.","family":"Suria","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Thoracic Aortic Surgery Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Reithofer","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Thoracic Aortic Surgery Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"H\u00fcbler","sequence":"additional","affiliation":[{"name":"University Heart and Vascular Center Hamburg University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Zimpfer","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Thoracic Aortic Surgery Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Granegger","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Thoracic Aortic Surgery Medical University of Vienna  Vienna Austria"},{"name":"University Heart and Vascular Center Hamburg University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,7]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Mechanical Circulatory and Respiratory Support","author":"Gregory S. 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