{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:01:33Z","timestamp":1790694093267,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2016995"],"award-info":[{"award-number":["2016995"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2010110"],"award-info":[{"award-number":["2010110"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["106675"],"award-info":[{"award-number":["106675"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018853","name":"Common Good","doi-asserted-by":"publisher","award":["RF2024\u2010O\u201002"],"award-info":[{"award-number":["RF2024\u2010O\u201002"]}],"id":[{"id":"10.13039\/501100018853","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018853","name":"Common Good","doi-asserted-by":"publisher","award":["RF2025\u2010ECR\u201001"],"award-info":[{"award-number":["RF2025\u2010ECR\u201001"]}],"id":[{"id":"10.13039\/501100018853","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Venoarterial extracorporeal membrane oxygenation (VA ECMO) is a life\u2010saving therapy that provides cardiorespiratory support for cardiogenic shock patients. But, due to altered flow dynamics induced by VA ECMO drainage cannulas, complications such as thrombosis and hemolysis are common. Therefore, this study aimed to develop an optimized drainage cannula design with reduced complication risk using computational fluid dynamics (CFD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The multi\u2010objective optimization process entailed generating a response surface based on a design of experiments with\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009540 unique cannula designs. Minimizing pressure drop, maintaining &gt;\u2009100\u2009mm\/s tip velocity, and minimization of average wall shear stress were assigned as objective functions. The optimized design was then tested in three patient\u2010specific geometries using CFD and compared against a clinically available model (Maquet).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The final design consisted of three rows of five side holes, with all side holes titled at an angle of 31.5\u00b0. When compared to the Maquet model, the optimized cannula generated lower stagnant blood volumes, increased cannula tip velocities (&gt;\u2009300\u2009mm\/s), and increased drainage from the upper body.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The optimized cannula developed in this study demonstrated favorable flow dynamics that may increase flow and reduce the risk of life\u2010threatening complications including thrombosis and hemolysis when translated to a clinical setting, thereby improving VA ECMO patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.70203","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T03:40:54Z","timestamp":1784518854000},"page":"1372-1383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Optimized Multi\u2010Stage Drainage Cannula Design for Venoarterial Extracorporeal Membrane Oxygenation"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2623-7009","authenticated-orcid":false,"given":"Avishka","family":"Wickramarachchi","sequence":"first","affiliation":[{"name":"Advanced Cardiorespiratory Engineering Laboratory, Faculty of Engineering Queensland University of Technology  Brisbane Australia"},{"name":"Centre for Biomedical Technologies, School of Mechanical, Medical and Process Engineering, Faculty of Engineering Queensland University of Technology  Brisbane Australia"},{"name":"Cardio\u2010Respiratory Engineering and Technology Laboratory, Department of Mechanical and Aerospace Engineering, Faculty of Engineering Monash University  Clayton Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Khamooshi","sequence":"additional","affiliation":[{"name":"Advanced Cardiorespiratory Engineering Laboratory, Faculty of Engineering Queensland University of Technology  Brisbane Australia"},{"name":"Centre for Biomedical Technologies, School of Mechanical, Medical and Process Engineering, Faculty of Engineering Queensland University of Technology  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8430-9678","authenticated-orcid":false,"given":"Aidan","family":"Burrell","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Alfred Hospital  Melbourne Victoria Australia"},{"name":"Australian and New Zealand Intensive Care Research Centre Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5448-1917","authenticated-orcid":false,"given":"Shaun D.","family":"Gregory","sequence":"additional","affiliation":[{"name":"Advanced Cardiorespiratory Engineering Laboratory, Faculty of Engineering Queensland University of Technology  Brisbane Australia"},{"name":"Centre for Biomedical Technologies, School of Mechanical, Medical and Process Engineering, Faculty of Engineering Queensland University of Technology  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-016-4636-5"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.13859"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2020.12.007"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001230"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003650"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2023.107407"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2024.108135"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2019.04.81"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-018-0512-1"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000002466"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-024-05121-9"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/02676591241256502"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/854938"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000002360"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001440"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001669"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000002027"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0137907"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00241.2001"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-024-07659-2"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3233\/BIR-1991-283-415"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00649.2021"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2011.01243.x"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001694"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.12.050"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000002687"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2021.110393"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-3779-0"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0267659119830514"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/0267659118782246"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.807663"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0791-2"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13246-022-01203-6"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-9784.197791"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/1023697X.2010.10668215"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.70203","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aor.70203","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.70203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:47:39Z","timestamp":1790693259000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.70203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,19]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/aor.70203"],"URL":"https:\/\/doi.org\/10.1111\/aor.70203","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,19]]},"assertion":[{"value":"2025-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}