{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:02:28Z","timestamp":1790694148626,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>As a core component of mechanical circulatory support devices, a centrifugal blood pump with excessively low hydraulic efficiency can lead to poor blood compatibility, low efficiency, excessive heat generation, insufficient blood supply, and pressure fluctuations. These issues adversely affect patient prognosis. To address these bottlenecks, this study aims to perform structural optimization of the centrifugal blood pump with the goal of improving hydraulic efficiency and exploring suitable optimization methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study takes the UJN\u20101 magnetically suspended centrifugal blood pump as the research object, with hydraulic efficiency simulated by computational fluid dynamics (CFD) as the target, and compares the results of optimizing four impeller parameters (blade inlet angle, outlet angle, number of blades, blade height) using orthogonal experiments and neural network\u2010genetic algorithm (NN\u2010GA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Genetic algorithm (GA) optimization yielded an impeller with 20.48\u00b0 inlet angle, 17.22\u00b0 outlet angle, 6 blades, and 4.55\u2009mm height. Its hydraulic efficiency increased by 2.38%, outlet pressure fluctuation decreased significantly, and it outperformed the orthogonal pump by 1.57%. Hydraulic experiments validated the results, with deviations within approximately \u00b11% of CFD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The NN\u2010GA demonstrates superior global optimization capabilities to the orthogonal experiment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>This study provides new insights for multi\u2010parameter coupled centrifugal blood pump optimization and guides pump design in energy, chemical, and semiconductor industries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.70208","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T06:10:29Z","timestamp":1787379029000},"page":"1476-1486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Structural Optimization Design and Experimental Study of Centrifugal Blood Pump Impeller"],"prefix":"10.1111","volume":"50","author":[{"given":"Qing","family":"Han","sequence":"first","affiliation":[{"name":"School of Mechanical Engineering University of Jinan  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9796-9569","authenticated-orcid":false,"given":"Xuemin","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering University of Jinan  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiejie","family":"Shao","sequence":"additional","affiliation":[{"name":"Ningbo Zhongjie Laitong Technology Co., Ltd.  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering University of Jinan  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghua","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering University of Jinan  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/fluids9070157"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/hearts5010008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001297"},{"issue":"20","key":"e_1_2_10_5_1","first-page":"12","article-title":"Updates on Management of Advanced Heart Failure","volume":"5","author":"Bas H. 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