{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T04:57:55Z","timestamp":1785387475092,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Membrane lung (ML) resistance is commonly monitored during extracorporeal membrane oxygenation (ECMO) to forewarn of circuit obstruction, but differences in device design and patient hemorheological factors may complicate interpretation. We sought to determine whether a stable baseline resistance exists shortly after ECMO initiation and to identify factors associated with baseline variability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a single\u2010center retrospective cohort study of adult patients receiving veno\u2010arterial or veno\u2010venous ECMO between 2011 and 2023. Baseline resistance was calculated as the mean inlet\u2013outlet pressure difference normalized to flow during the first 2 and 3\u2009h after initiation. Descriptive statistics and linear regression evaluated associations between patient and device characteristics and baseline resistance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 170 patients, 33 (19.4%) used the Sorin EOS ML and 135 (79.4%) used the Quadrox\u2010i Small Adult ML, and 2 (1.2%) used other ML models that were excluded from model\u2010specific analysis. Resistance stabilized within 2\u20133\u2009h post\u2010initiation. Baseline resistance varied by ML model: median 31.7\u2009mmHg\u00b7min\/L for Sorin versus 5.5\u2009mmHg\u00b7min\/L for Quadrox (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Each 1 unit increase in hematocrit increased baseline resistance by 0.54 (95% CI: 0.13 to 0.95) for Sorin, and by 0.05 (95% CI: 0.02 to 0.09) for Quadrox. Female sex was associated with lower resistance compared to male sex (Sorin: \u22126.92\u2009mmHg\u00b7min\/L, 95% CI \u221211.28 to \u22122.56; Quadrox: \u22120.63\u2009mmHg\u00b7min\/L, 95% CI \u22121.06 to \u22120.20). Additional associations varied by device model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Baseline ML resistance reflects device design and patient hemorheology. Early resistance provides a stable baseline reference, though patient hemorheology may confound resistance deviations attributed to true ML obstruction. Device\u2010specific and physiologically adjusted interpretation may personalize detection of ML obstruction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.70210","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T04:00:17Z","timestamp":1785384017000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Determinants of Baseline Membrane Lung Resistance in Extracorporeal Membrane Oxygenation"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7495-3009","authenticated-orcid":false,"given":"Giancarlo","family":"Sabetta","sequence":"first","affiliation":[{"name":"Renaissance School of Medicine Stony Brook University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5484-399X","authenticated-orcid":false,"given":"Xiaoyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Biostatistical Consulting Core, Office of Scientific Affairs, Renaissance School of Medicine Stony Brook University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Family, Population and Preventive Medicine, Renaissance School of Medicine Stony Brook University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleem","family":"Zaidi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Renaissance School of Medicine Stony Brook University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1927-2113","authenticated-orcid":false,"given":"Jonathon","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Renaissance School of Medicine Stony Brook University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000133"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00352"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010020\u201003388\u20102"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001368"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1051\/ject\/2023047"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0267659118765883"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439\u2010021\u201002878\u2010w"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100043\u20101772843"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e318186a807"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1051\/ject\/2003351104"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001630"},{"key":"e_1_2_9_13_1","volume-title":"EOS ECMO: Instructions for Use","author":"Sorin Group Italia S.r.l.","year":"2022"},{"key":"e_1_2_9_14_1","volume-title":"QUADROX\u2010i Small Adult and Adult","author":"Maquet Cardiopulmonary AG","year":"2015"},{"key":"e_1_2_9_15_1","unstructured":"\u201cANSI\/AAMI BP22:1994 (R2016) \u201daccessed November 6 2025 https:\/\/webstore.ansi.org\/standards\/aami\/ansiaamibp221994r2016\u20101729604."},{"key":"e_1_2_9_16_1","unstructured":"\u201cIEC 60601\u20102\u201034:2024 \u201daccessed November 6 2025 https:\/\/webstore.iec.ch\/en\/publication\/68609."},{"key":"e_1_2_9_17_1","unstructured":"SAS Support \u201cUsage Note 59081: Mediation Analysis \u201d(2019) accessed September 14 2025 https:\/\/support.sas.com\/kb\/59\/081.html."},{"key":"e_1_2_9_18_1","volume-title":"Causal Mediation Analysis With the CAUSALMED Procedure","author":"Yung Y. 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