{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T07:08:12Z","timestamp":1789110492844,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009968","name":"Tiroler Wissenschaftsf\u00f6rderung","doi-asserted-by":"publisher","award":["F.16942\/5\u20102019"],"award-info":[{"award-number":["F.16942\/5\u20102019"]}],"id":[{"id":"10.13039\/501100009968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Due to the high adenosine\u2010triphosphate (ATP) consumption of the myocardial tissue, cardiac function is dependent on efficient mitochondrial respiration. Ischemia and reperfusion injury (I\/R) has a severe impact on the function of the mitochondrial respiratory system.\n                      <jats:italic>Ex\u2010situ<\/jats:italic>\n                      heart perfusion (ESHP) can minimize I\/R injury. We investigated mitochondrial respiration using high\u2010resolution respirometry (HRR) in a porcine model during ESHP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Six German domestic pigs were used as heart and blood donors. Normothermic ESHP was performed over 6\u2009h. Tissue homogenate of porcine myocardium was assessed by HRR at baseline (starting sample), after 60, 180, and 360\u2009min of ESHP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The combined oxidative phosphorylation capacity with NADH, fatty acid and succinate fuel substrates remained stable during ESHP (starting sample: 198\u2009\u00b1\u200959.7, 60\u2009min: 196.5\u2009\u00b1\u200966.7, 180\u2009min: 207.5\u2009\u00b1\u200948.1, 360\u2009min: 200.5\u2009\u00b1\u200927.9\u2009pmol\u00b7s\n                      <jats:sup>\u22121<\/jats:sup>\n                      \u00b7mg wet mass\n                      <jats:sup>\u22121<\/jats:sup>\n                      ;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.707). The flux control ratio of the nicotinamide adenine dinucleotide hydrogen (NADH) pathway (starting sample: 0.43\u2009\u00b1\u20090.07, 60\u2009min: 0.43\u2009\u00b1\u20090.05, 180\u2009min: 0.47\u2009\u00b1\u20090.05, 360\u2009min: 0.44\u2009\u00b1\u20090.07\u2009pmol\u00b7s\n                      <jats:sup>\u22121<\/jats:sup>\n                      \u00b7mg wet mass\n                      <jats:sup>\u22121<\/jats:sup>\n                      ;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.549) and succinate\u2010pathway (starting sample: 0.49\u2009\u00b1\u20090.06, 60\u2009min: 0.49\u2009\u00b1\u20090.05, 180\u2009min: 0.48\u2009\u00b1\u20090.01, 360\u2009min: 0.5\u2009\u00b1\u20090.05\u2009pmol\u00b7s\n                      <jats:sup>\u22121<\/jats:sup>\n                      \u00b7mg wet mass\n                      <jats:sup>\u22121<\/jats:sup>\n                      ;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.814) did not change during perfusion. The mitochondrial outer membrane damage was significantly decreased after 360\u2009min of ESHP (starting sample: 0.39\u2009\u00b1\u20090.07, 60\u2009min: 0.27\u2009\u00b1\u20090.06, 180\u2009min: 0.18\u2009\u00b1\u20090.03, 360\u2009min: 0.17\u2009\u00b1\u20090.02;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0124).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings demonstrate that normothermic ESHP preserves mitochondrial respiratory function in a porcine model over 6\u2009h. These results provide a mechanistic basis for the potential protective role of normothermic ESHP against ischemia\u2013reperfusion injury. HRR represents a promising investigational tool for in\u2010depth mitochondrial assessment during ESHP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.70213","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T06:42:48Z","timestamp":1789108968000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Monitoring Mitochondrial Function With High\u2010Resolution Respirometry During Ex\u2010Situ Heart Perfusion"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9173-7336","authenticated-orcid":false,"given":"Lukas","family":"Stastny","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Department of Visceral, Transplant and Thoracic Surgery Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andras T.","family":"Meszaros","sequence":"additional","affiliation":[{"name":"Department of Visceral, Transplant and Thoracic Surgery Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Ampferer","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0205-9885","authenticated-orcid":false,"given":"Gabriel","family":"Putzer","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care Medicine Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Perkins","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Huemer","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Sommerauer","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Martini","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care Medicine Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care Medicine Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Grimm","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schneeberger","sequence":"additional","affiliation":[{"name":"Department of Visceral, Transplant and Thoracic Surgery Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Dumfarth","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Medical University of Innsbruck  Innsbruck Austria"},{"name":"Department of Cardiac and Thoracic Aortic Surgery Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"issue":"2","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1097\/00007890-199202010-00007","article-title":"Limitations of Heart Preservation by Cold Storage","volume":"53","author":"Stringham J. 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