{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T06:26:48Z","timestamp":1786602408725,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Post\u2010myocardial infarction ventricular septal defect (VSD) is a rare but highly lethal complication of acute myocardial infarction. In cases of extensive septal destruction, surgical reconstruction is often not feasible. We report the first clinical experience with implantation of the Aeson total artificial heart (TAH) in patients with irreparable post\u2010infarction VSD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter retrospective analysis included 10 male patients with severe cardiogenic shock who underwent Aeson TAH implantation at four centers in Germany and France between November 2022 and March 2025. All patients required temporary mechanical circulatory support before implantation. Previous surgical VSD repair had failed in four patients, while six were considered unsuitable for surgical reconstruction because of extensive basal septal defects involving the atrioventricular valve apparatus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Following TAH implantation, early extubation was achieved in most patients, whereas three required temporary veno\u2010venous extracorporeal membrane oxygenation support. No cases of permanent renal failure, irreversible hepatic dysfunction, or neurological complications such as stroke were observed. Eight patients (80%) were successfully bridged to heart transplantation after a median support duration of 167\u2009days, while one patient remains on ongoing device support. During a median follow\u2010up of 351\u2009days (interquartile range, 202\u2013470\u2009days), four patients died. Overall survival was 80% at 6\u2009months and 60% at 1\u2009year after implantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Aeson TAH implantation appears to be a feasible bridge\u2010to\u2010transplant strategy for selected patients with irreparable post\u2010myocardial infarction VSD. The procedure provided hemodynamic stabilization, facilitated recovery of end\u2010organ function, and resulted in favorable short\u2010 to mid\u2010term outcomes in an otherwise fatal clinical condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.70218","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T05:28:21Z","timestamp":1786598901000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Initial Experience With the Aeson Total Artificial Heart in Patients With Ventricular Septal Defect After Acute Myocardial Infarction"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5718-4829","authenticated-orcid":false,"given":"Michal","family":"Nozdrzykowski","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, University of Leipzig Heart Center  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Bouchot","sequence":"additional","affiliation":[{"name":"Cardiovascular and Thoracic Surgery Department Dijon University Hospital  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4081-786X","authenticated-orcid":false,"given":"Andre","family":"Vincentelli","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery University of Lille, CHU Lille  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Panholzer","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery University Hospital Schleswig\u2010Holstein  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saed","family":"Jazayeri","sequence":"additional","affiliation":[{"name":"Cardiovascular and Thoracic Surgery Department Dijon University Hospital  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3189-8119","authenticated-orcid":false,"given":"Mouhamed","family":"Moussa","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Critical Care University of Lille  LIlle France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Latremouille","sequence":"additional","affiliation":[{"name":"Carmat SA  V\u00e9lizy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assad","family":"Haneya","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Thoracic Surgery, Trier Heart Centre Trier  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Borger","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University of Leipzig Heart Center  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey","family":"Dashkevich","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University of Leipzig Heart Center  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.jcin.2021.02.046","article-title":"Mechanical Circulatory Support as a Bridge to Definitive Treatment in Post\u2010Infarction Ventricular Septal Rupture","volume":"14","author":"Ronco D.","year":"2021","journal-title":"JACC. Cardiovascular Interventions"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/S0735-1097(00)00878-0","article-title":"Outcome and Profile of Ventricular Septal Rupture With Cardiogenic Shock After Myocardial Infarction: A Report From the SHOCK Trial Registry","volume":"36","author":"Menon V.","year":"2000","journal-title":"Journal of the American College of Cardiology"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1093\/eurheartj\/ehae363","article-title":"Ventricular Septal Defect Complicating Acute Myocardial Infarction: Diagnosis and Management. A Clinical Consensus Statement of the Association for Acute CardioVascular Care (ACVC) of the ESC, the European Association of Percutaneous Cardiovascular Interventions (EAPCI) of the ESC and the ESC Working Group on Cardiovascular Surgery","volume":"45","author":"Schlotter F.","year":"2024","journal-title":"European Heart Journal"},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1161\/01.CIR.101.1.27","article-title":"Risk Factors, Angiographic Patterns, and Outcomes in Patients With Ventricular Septal Defect Complicating Acute Myocardial Infarction. GUSTO\u2010I (Global Utilization of Streptokinase and TPA for Occluded Coronary Arteries) Trial Investigators","volume":"101","author":"Crenshaw B. S.","year":"2000","journal-title":"Circulation"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.athoracsur.2020.08.050","article-title":"Surgical Repair of Postinfarction Ventricular Septal Rupture: Systematic Review and Meta\u2010Analysis","volume":"112","author":"Matteucci M.","year":"2021","journal-title":"Annals of Thoracic Surgery"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1097\/MAT.0000000000001485","article-title":"First Clinical Experience With Pressure Sensor\u2013Based Autoregulation of Blood Flow in an Artificial Heart","volume":"67","author":"Netuka I.","year":"2021","journal-title":"ASAIO Journal"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1053\/j.optechstcvs.2024.01.002","article-title":"Implantation Technique for the Aeson Total Artificial Heart","volume":"29","author":"Vincentelli A.","year":"2024","journal-title":"Operative Techniques in Thoracic and Cardiovascular Surgery"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.21037\/acs-2021-ami-111","article-title":"Post\u2010infarction ventricular septal rupture","volume":"11","author":"David T. E.","year":"2022","journal-title":"Ann Cardiothorac Surgery"},{"issue":"9","key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.healun.2022.05.017","article-title":"Intermediate\u2010Dose Prophylactic Anticoagulation With Low Molecular Weight Heparin Is Safe After Bioprosthetic Artificial Heart Implantation","volume":"41","author":"Smadja D. M.","year":"2022","journal-title":"Journal of Heart and Lung Transplantation"},{"issue":"4","key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s10047-020-01170-3","article-title":"Review and Reflections About Pulsatile Ventricular Assist Devices From History to Future: Concerning Safety and Low Haemolysis\u2010Still Needed","volume":"23","author":"Koehne I.","year":"2020","journal-title":"Journal of Artificial Organs"},{"issue":"2","key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.hrtlng.2018.11.002","article-title":"Risk of Left Ventricular Assist Device Driveline Infection: A Systematic Literature Review","volume":"48","author":"Pavlovic N. V.","year":"2019","journal-title":"Heart & Lung"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.jchf.2025.01.023","article-title":"Initial Experience With the Aeson Total Artificial Heart in Cardiogenic Shock Patients on Extracorporeal Life Support","volume":"13","author":"Martin A. C.","year":"2025","journal-title":"JACC. Heart Failure"},{"issue":"2","key":"e_1_2_11_14_1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/aor.14860","article-title":"Outcomes After SynCardia Temporary Total Artificial Heart Implantation: A 20\u2010Year Single\u2010Center Experience in 196 Patients","volume":"49","author":"Razumov A.","year":"2025","journal-title":"Artificial Organs"},{"key":"e_1_2_11_15_1","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1093\/ejcts\/ezz041","article-title":"Pulmonary Artery Pressure Telemonitoring by CardioMEMS in a Patient Pre\u2010 and Post\u2010Left Ventricular Assist Device Implantation","volume":"56","author":"Veenis J. F.","year":"2019","journal-title":"European Journal of Cardio\u2010Thoracic Surgery"},{"key":"e_1_2_11_16_1","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1016\/j.jtcvs.2012.11.018","article-title":"The Role of the Total Artificial Heart in the Treatment of Post\u2010Myocardial Infarction Ventricular Septal Defect","volume":"145","author":"Ashfaq A.","year":"2013","journal-title":"Journal of Thoracic and Cardiovascular Surgery"},{"key":"e_1_2_11_17_1","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1056\/NEJMoa040186","article-title":"Cardiac Replacement With a Total Artificial Heart as a Bridge to Transplantation","volume":"351","author":"Copeland J. 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