{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:18:47Z","timestamp":1788175127651,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Extracorporeal circulation (ECC) has become an important component in cardiac surgery, for cardiopulmonary support, and as a bridge to transplantation. Optimization of systems, components, and management requires further refinements using relevant ECC models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A miniature silicone membrane oxygenator with a surface area of 134\u2009cm\n                      <jats:sup>2<\/jats:sup>\n                      and a pump\u2010head tube with internal dimension, ID 2.0\u2009mm, was connected to the rat with a double\u2010lumen tube, where the inner silicone tube (ID 1.0\u2009mm) was irrigated with temperature\u2010controlled water, serving as a heat\u2010exchanger.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The ECC system had a priming volume less than 1.5\u2009mL yet developed a pulsatile flow up to 11.6\u2009mL\/min, or 40\u2009mL\/min\/kg, for a 290\u2010g animal. The system kept sufficient gas exchange, sustained stable hemodynamics in heart failure, and induced hyperthermia (40\u00b0C) and hypothermia (20\u00b0C) successfully with long\u2010term survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A silicone\u2010based closed ECC system for rodents was developed as an experimental platform to address controversies, optimize management, and test the feasibility of new systems, components, or concepts in ECC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.70222","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:55:41Z","timestamp":1787986541000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Experimental Extracorporeal Circulation System: A Pilot Study in Rats"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0893-7888","authenticated-orcid":false,"given":"Akira T.","family":"Kawaguchi","sequence":"first","affiliation":[{"name":"Department of Pediatrics Tokai University School of Medicine  Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Inukai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tokai University School of Medicine  Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayuko","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tokai University School of Medicine  Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen T.","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tokai University School of Medicine  Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Sato","sequence":"additional","affiliation":[{"name":"Research and Development Fuji Systems Corporation  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiga","family":"Aburaya","sequence":"additional","affiliation":[{"name":"Research and Development Fuji Systems Corporation  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Bergsland","sequence":"additional","affiliation":[{"name":"The Intervention Center Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3089-2332","authenticated-orcid":false,"given":"Yoshiyuki","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tokai University School of Medicine  Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"issue":"3","key":"e_1_2_12_2_1","first-page":"I30","article-title":"Total Bloodless Open Heart Surgery in the Pediatric Age Group","volume":"70","author":"Kawaguchi A.","year":"1984","journal-title":"Circulation"},{"issue":"19","key":"e_1_2_12_3_1","first-page":"II385","article-title":"Neurological Function After Deep Hypothermic Circulatory Arrest in the Rat","volume":"98","author":"Kawaguchi A. 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