{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T05:17:43Z","timestamp":1787894263366,"version":"build-2784847793"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic respiratory diseases are the third leading global cause of death. As lung transplantation is a definitive treatment for highly selected candidates, extracorporeal membrane oxygenation (ECMO) can be a life\u2010sustaining therapy. Standard ECMO therapy immobilizes the patient, which increases morbidity and mortality. There is a need for a portable venovenous (VV)\u2010ECMO device that allows hospital ambulation and ultimately home use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This systematic review aims to identify clinically utilized and preclinical portable respiratory assist devices and describe their efficiency, progress, and innovative design features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      A comprehensive systematic search was conducted in six databases: PubMed, Cochrane, EMBASE, Inspect Engineering Village, ScienceDirect, and\n                      <jats:italic>Journal of Heart and Lung Transplantation<\/jats:italic>\n                      until July 25, 2025. A total of 562 articles were screened, and 16 were included.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eight portable respiratory assist devices were identified. Among these, the CE\u2010marked MobyBox and the FDA\u2010approved Breethe OXY\u20101 system are in clinical use. Two devices, the APL and the PAAL, are no longer in active development but have each laid the foundation for the Breethe OXY\u20101 system and the ModELAS device. Additionally, implementation of the PAL machine was not completed but led to the development of the double\u2010lumen cannula. The remaining three portable ECMO devices are still undergoing preclinical testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Several different portable ECMO devices have been developed, demonstrating substantial progress toward portable extracorporeal support. However, optimized anticoagulation strategies and safe mobilization require further investigation before widespread clinical adaptation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>PROSPERO registration number: CRD420251051796<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.70230","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T04:25:01Z","timestamp":1787891101000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Progress Toward a Portable Artificial Lung: A Systematic Review"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9404-6145","authenticated-orcid":false,"given":"Maja Munk","family":"Svendsen","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6106-1169","authenticated-orcid":false,"given":"Clara Kj\u00e6r","family":"Hendriksen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Folkersen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health Aarhus University  Aarhus Denmark"},{"name":"Department of Anesthesia and Intensive Care Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Juhl\u2010Olsen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health Aarhus University  Aarhus Denmark"},{"name":"Department of Anesthesia and Intensive Care Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1298-0299","authenticated-orcid":false,"given":"Leila Louise","family":"Benhassen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2352-853X","authenticated-orcid":false,"given":"S\u00f8ren Nielsen","family":"Skov","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.101936"},{"issue":"7","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"4574","DOI":"10.21037\/jtd.2018.06.141","article-title":"Lung Transplantation: Indications and Contraindications","volume":"10","author":"Weill D.","year":"2018","journal-title":"Journal of Thoracic Disease"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd9020034"},{"issue":"2","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1097\/MAT.0000000000002030","article-title":"Pilot Testing of a Lightweight, Pulmonary Assist System in an Ambulatory Sheep Model of Destination Therapy Respiratory Support","volume":"70","author":"Roberts K. 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