{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:05:24Z","timestamp":1790053524758,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010981","name":"Izumi Science and Technology Foundation","doi-asserted-by":"publisher","award":["2202\u2010J\u2010014"],"award-info":[{"award-number":["2202\u2010J\u2010014"]}],"id":[{"id":"10.13039\/501100010981","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Human skin is mainly composed of an epidermal layer of stratified keratinocytes and a dermal layer containing fibroblasts and extracellular matrix (ECM). Epidermal\u2013dermal models that replicate both the epidermis and dermis are widely used for skin evaluation. However, it remains challenging to reproduce the complex dermal ECM using artificial materials. Although decellularized dermis from human and animal sources is composed of dermal ECM, its application as a substrate for skin models has not progressed due to the difficulty of recellularization in\u00a0vitro.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We previously reported that cells are more likely to infiltrate into decellularized fetal porcine bone marrow than decellularized adult porcine bone marrow. In the present study, we developed a skin model by seeding human fibroblasts and keratinocytes onto a decellularized fetal porcine dermis (dFPDe).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fibroblasts infiltrated into the dFPDe and keratinocytes formed a stratified epidermal layer on its surface. The compressive elastic modulus and permeability of the dFPDe\u2010based skin model were similar to those of human skin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results suggest that dFPDe could be a useful substrate for the development of physiological skin models.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.70243","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:38:51Z","timestamp":1790051931000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Decellularized Fetal Porcine Dermis as a Substrate for Skin Models"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4416-2339","authenticated-orcid":false,"given":"Kohei","family":"Kaburagi","sequence":"first","affiliation":[{"name":"Faculty of Textile Science and Technology Shinshu University  Ueda Nagano Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0537-8291","authenticated-orcid":false,"given":"Yoshihide","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Laboratory for Biomaterials and Bioengineering Institute of Integrated Research, Institute of Science Tokyo  Chiyoda\u2010ku Tokyo Japan"},{"name":"Division of Medical Devices National Institute of Health Sciences  Kawasaki\u2010shi Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5676-6222","authenticated-orcid":false,"given":"Jun","family":"Negishi","sequence":"additional","affiliation":[{"name":"Faculty of Textile Science and Technology Shinshu University  Ueda Nagano Japan"},{"name":"Laboratory for Biomaterials and Bioengineering Institute of Integrated Research, Institute of Science Tokyo  Chiyoda\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"issue":"3","key":"e_1_2_11_2_1","article-title":"Modelling the Complexity of Human Skin In\u00a0Vitro","volume":"11","author":"Hofmann E.","year":"2023","journal-title":"Biomedicine"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics17101342"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s44164-023-00058-9"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202501894"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2022.133909"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15776"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-021-00579-4"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(03)00057-6"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/asjof\/ojab019"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0955-0674(92)90102-I"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering8110148"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14911"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.09.068"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssynbio.1c00547"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.2c00342"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.12556"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15071906"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10695"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.393"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25074020"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiosc.2024.03.008"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10047-011-0570-z"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.3.1274"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33898-7"},{"key":"e_1_2_11_26_1","first-page":"1","volume-title":"Neonatal Dermatology","author":"Loomis C. 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