{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:51:48Z","timestamp":1792036308011,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Artificial Organs"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Short\u2010duration (1\u20132\u2009h) dual hypothermic oxygenated machine perfusion (DHOPE) reduces ischemia\u2010reperfusion injury\u2010related complications. Prolonged DHOPE preservation (DHOPE\u2010PRO) may facilitate logistics. We assessed the economic impact of DHOPE\u2010PRO versus conventional short\u2010duration DHOPE, hypothesizing that DHOPE\u2010PRO would not be associated with increased one\u2010year transplantation\u2010related costs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This post hoc economic evaluation of the prospective DHOPE\u2010PRO trial (NL8740) included adult recipients of livers donated after brain death. All transplantation\u2010related medical expenses up to one year post\u2010transplant were collected. The cost of resource use was calculated using 2022 full hospital prices indexed to 2024. Time\u2010driven variable costing was applied to perfusion, surgery, and intensive care costs. The primary outcome was total one\u2010year transplantation\u2010related cost.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 24 patients, 12 received a liver after DHOPE and 12 after DHOPE\u2010PRO. Median one\u2010year total costs were \u20ac83\u2009583 [interquartile range (IQR) 78\u2009400\u2013104\u2009158] for DHOPE and \u20ac78\u2009582 [IQR 73123\u201392\u2009855] for DHOPE\u2010PRO (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.347). Perfusion costs were higher with DHOPE\u2010PRO (\u20ac23\u2009926 [IQR 22711\u201324\u2009697] versus \u20ac17\u2009306 [IQR 16928\u201317\u2009594];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), while surgery costs were lower (\u20ac18\u2009560 [IQR 17806\u201320\u2009747] versus \u20ac21\u2009303 [IQR 19535\u201325\u2009418];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033). Costs related to other medical activities did not differ between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this exploratory single\u2010center economic evaluation, DHOPE\u2010PRO enabled daytime liver transplantation without evidence of increased one\u2010year transplantation\u2010related costs compared with short\u2010duration DHOPE. Higher perfusion\u2010related costs were accompanied by lower surgery\u2010related costs in this cohort. These findings warrant confirmation in larger studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Netherlands Trial Registry number: NL8740<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.70267","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:41:24Z","timestamp":1792035684000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Economic Evaluation of Prolonged Hypothermic Oxygenated Machine Perfusion Enabling Daytime Liver Transplantation"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1325-1051","authenticated-orcid":false,"given":"Linda C.","family":"Woltjes","sequence":"first","affiliation":[{"name":"Section of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University of Groningen University Medical Center Groningen  Groningen the Netherlands"},{"name":"UMCG Comprehensive Transplant Center  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijke I.","family":"Bonnema","sequence":"additional","affiliation":[{"name":"Department of Strategic Analytics, Finance and Control, University of Groningen University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8557-7081","authenticated-orcid":false,"given":"Isabel M. A.","family":"Br\u00fcggenwirth","sequence":"additional","affiliation":[{"name":"Section of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University of Groningen University Medical Center Groningen  Groningen the Netherlands"},{"name":"UMCG Comprehensive Transplant Center  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6931-2825","authenticated-orcid":false,"given":"Veerle A.","family":"Lantinga","sequence":"additional","affiliation":[{"name":"Section of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University of Groningen University Medical Center Groningen  Groningen the Netherlands"},{"name":"UMCG Comprehensive Transplant Center  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian S.","family":"van der Hilst","sequence":"additional","affiliation":[{"name":"Department of Strategic Analytics, Finance and Control, University of Groningen University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7900-5917","authenticated-orcid":false,"given":"Vincent E.","family":"de Meijer","sequence":"additional","affiliation":[{"name":"Section of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University of Groningen University Medical Center Groningen  Groningen the Netherlands"},{"name":"UMCG Comprehensive Transplant Center  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the DHOPE\u2010PRO Trial Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.09.019"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010025\u201001085\u20105"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.17115"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2031532"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005110"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.12.030"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000006055"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000715"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/LVT.0000000000000567"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000005232"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2010.03177.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1802337"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102411"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast\u20102021\u2010000842"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2026.5039"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/LVT.0000000000000944"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/LVT.0000000000000560"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/txd.0000000000001861"}],"container-title":["Artificial 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