{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:05:24Z","timestamp":1773234324764,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,2,7]],"date-time":"2013-02-07T00:00:00Z","timestamp":1360195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold>To investigate the clinical value of assessment of peripapillary retinal nerve fibre layer (RNFL) thickness with OCT in addition to the evaluation of retinal function measured by full\u2010field electroretinography (ff\u2010ERG) in patients with suspected vigabatrin (VGB)\u2010attributed visual field defects.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold>Visual fields from adult patients in our clinical follow\u2010up program for VGB medication were analysed. Twelve patients with suspected VGB\u2010attributed visual field defects were selected for the study. They were re\u2010examined with computerized kinetic perimetry, ff\u2010ERG and OCT (2D circle scan).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>Constricted visual fields were found in all patients. Comparative analysis of ff\u2010ERG parameters showed reduced b\u2010wave amplitudes for the isolated and the combined rod and cone responses (p\u2003<jats:italic>&lt;\u2003<\/jats:italic>0.0001). The a\u2010wave, reflecting photoreceptor activity, was reduced (p\u2003=<jats:italic>\u2003<\/jats:italic>0.001), as well as the summed amplitude of oscillatory potentials (p\u2003=<jats:italic>\u2003<\/jats:italic>0.029), corresponding to inner retinal function. OCT measurements demonstrated attenuation of the RNFL in nine of 12 patients, most frequently superiorly and\/or inferiorly. No temporal attenuation was found. Significant positive correlations were found between the total averaged RNFL thickness, superior and inferior RNFL thickness and reduced ff\u2010ERG parameters. Positive correlations were also found between RNFL thickness and isopter areas.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold>OCT measurements can detect attenuation of the RNFL in patients exposed to VGB medication. RNFL thickness correlates with reduced ff\u2010ERG parameters and isopter areas of constricted visual fields, indicating that VGB is retino\u2010toxic on several levels, from photoreceptors to ganglion cells. The study also supports previous studies, suggesting that OCT measurement of the RNFL thickness may be of clinical value in monitoring patients on vigabatrin therapy.<\/jats:p>","DOI":"10.1111\/aos.12030","type":"journal-article","created":{"date-parts":[[2013,2,7]],"date-time":"2013-02-07T10:47:21Z","timestamp":1360234041000},"page":"149-157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Attenuation of the retinal nerve fibre layer and reduced retinal function assessed by optical coherence tomography and full\u2010field electroretinography in patients exposed to vigabatrin 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