{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:36:20Z","timestamp":1790217380774,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,5,7]],"date-time":"2013-05-07T00:00:00Z","timestamp":1367884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold> To evaluate the effect of early vitreoretinal surgery on vascularly active stage 4 ROP through the preoperative use of intravitreal bevacizumab.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> This was a retrospective study. Eighteen patients with vascularly active stage 4 ROP who underwent primary vitrectomy from April 2007 to March 2010 were enrolled. Twelve eyes from eight patients received one\u2010time intravitreal injection of 0.625\u2003mg bevacizumab 7\u2003days prior to vitrectomy (bevacizumab group), and 11 eyes from 10 patients underwent the surgical procedure without bevacizumab (control group). Demographical information of all patients was recorded. The patients were followed up for 12\u201336\u2003months after the surgery. The postmenstrual age at vitrectomy, surgical procedure, anatomical and visual outcome, adverse effects and surgical complications were compared.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> There was no statistically significant difference between the two groups in gender, birthweight and gestational age. The bevacizumab group showed remarkable regression of vascular activity after the injection. The mean postmenstrual age at the time of vitrectomy was significantly earlier in the bevacizumab group (40 versus 47\u2003weeks, p\u2003=\u20030.002) compared with the controls. The mean surgery time was shorter in the bevacizumab group (74.81 versus 101.70\u2003min, bevacizumab group versus control, p\u2003=\u20030.002). At the final follow\u2010up, all patients in the bevacizumab group achieved anatomical retinal attachment, compared with 70% in the control group. Eighty\u2010eight per cent patients in the bevacizumab group obtained pattern vision, while it was 30% in the control group (p\u2003=\u20030.015).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Intravitreal bevacizumab administrated prior to vitrectomy effectively reduced active neovascularization in vascularly active stage 4 ROP patients, thus advancing the timing of vitrectomy and facilitating pars plicata vitrectomy (PPV).<\/jats:p>","DOI":"10.1111\/aos.12055","type":"journal-article","created":{"date-parts":[[2013,5,7]],"date-time":"2013-05-07T06:54:45Z","timestamp":1367909685000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Early vitreoretinal surgery on vascularly active stage 4 retinopathy of prematurity through the preoperative intravitreal bevacizumab 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