{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T05:11:30Z","timestamp":1696569090834},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T00:00:00Z","timestamp":1363564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold> To evaluate the reproducibility of measurements of area of \u03b2\u2010zone parapapillary atrophy (\u03b2\u2010PPA) using blue laser fundus autofluorescence (FAF) and confocal scanning laser ophthalmoscopy reflectance (CSLO) measurements and to assess agreement between the two imaging modalities.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Sixty\u2010five eyes of 45 patients (mean age, 68.2\u2003\u00b1\u200311.3\u2003years) with established or suspected glaucoma from the Diagnostic Innovations in Glaucoma Study (DIGS) were prospectively included. FAF scans were obtained with the Spectralis HRA+OCT and CSLO reflectance images with the HRTII (both from Heidelberg Engineering, Heidelberg, Germany). Two masked graders independently measured \u03b2\u2010PPA area on 3 consecutive scans using the semi\u2010automated BluePeak RegionFinder software (BPRF) and on CSLO reflectance images using the optic disc contour line. Reproducibility of \u03b2\u2010PPA area measurements was assessed using intraclass correlation coefficients (ICC).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Intragrader reproducibility was 0.997 (95% CI, 0.996\u20130.998) and 0.995 (95% CI, 0.992\u20130.996) for grader 1 and 2, respectively, using FAF\u2010BPRF, and by CSLO, it was 0.991 (95% CI, 0.986\u20130.994) and 0.988 (95% CI, 0.982\u20130.992). Intergrader agreement (ICC) was 0.53 (95% CI, 0.331\u20130.685) for FAF\u2010BPRF and 0.404 (95% CI, 0.149\u20130.601) for CSLO (comparison between ICC, p\u2003=\u20030.368). Agreement (ICC) between the two devices was worse for grader 1 (0.356; 95% CI, 0.129\u20130.549) than grader 2 (0.856; 95% CI, 0.774\u20130.910) (p\u2003&lt;\u20030.001).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Despite excellent intragrader reproducibility for \u03b2\u2010PPA measurements with FAF\u2010BPRF and CSLO, intergrader reproducibility is low to moderate. Measurements of \u03b2\u2010PPA area obtained with the two instruments are of moderate agreement and, therefore, are not interchangeable.<\/jats:p>","DOI":"10.1111\/aos.12057","type":"journal-article","created":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T12:07:17Z","timestamp":1363608437000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Semiautomated quantification of \u03b2\u2010zone parapapillary atrophy using blue light fundus autofluorescence"],"prefix":"10.1111","volume":"91","author":[{"given":"Kaweh","family":"Mansouri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan D.","family":"Tung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe A.","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Tafreshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syril","family":"Dorairaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Zangwill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert N.","family":"Weinreb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1985.01050020055018"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(94)31153-5"},{"key":"e_1_2_7_4_1","first-page":"646","article-title":"Enlargement of parapapillary atrophy in follow\u2010up of chronic open\u2010angle glaucoma","volume":"137","author":"Budde WM","year":"2004","journal-title":"Am J Ophthalmol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(89)90010-6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)10116-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.icu.0000156135.20570.30"},{"key":"e_1_2_7_8_1","first-page":"919","article-title":"Parapapillary chorioretinal atrophy in normal and glaucoma eyes. 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