{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:31:07Z","timestamp":1788543067013,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,2,7]],"date-time":"2013-02-07T00:00:00Z","timestamp":1360195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold> To investigate the clinical features of all patients with acute\u2013onset diplopia presenting to the ophthalmology department.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> The notes of every patient who presented with acute onset (&lt;4\u2010week duration) diplopia to the ophthalmology clinic over a 2\u2010year period were reviewed. Data regarding clinical features, underlying aetiology, past medical history, investigations and outcomes were extracted.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> One hundred and forty\u2010nine patients presented with 53.7% having an isolated third, fourth or sixth nerve palsy, 10.7% a mechanical cause, 10.1% a dysfunction of higher control, 8.1% decompensation of a pre\u2010existing heterophoria, 6.7% idiopathic, 5.4% causes of monocular diplopia and 5.3% another diagnosis. Neuroradiological investigation identified that &lt;5% of patients had a serious underlying pathology, which required immediate management; 80.5% had a diagnosis and underlying aetiology, which were obvious at presentation based only on clinical information and evaluation.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Acute onset diplopia is an uncommon and challenging presentation for the ophthalmologist to manage. These results demonstrate that the aetiology is commonly identifiable at the first presentation based on clinical evaluation, only a small percentage require urgent radiological investigation and a small minority of cases are likely to have serious emergent pathology.<\/jats:p>","DOI":"10.1111\/aos.12062","type":"journal-article","created":{"date-parts":[[2013,2,7]],"date-time":"2013-02-07T12:03:05Z","timestamp":1360238585000},"page":"382-386","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Acute\u2013onset diplopia"],"prefix":"10.1111","volume":"92","author":[{"given":"Una","family":"O\u2019Colmain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Gilmour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline J.","family":"MacEwen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1444-0938.2006.00101.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702415"},{"key":"e_1_2_6_4_1","first-page":"12","article-title":"The effect of ageing on eye movement: a literature review","volume":"59","author":"Davidson JH","year":"2002","journal-title":"Br Orthopt J"},{"key":"e_1_2_6_5_1","first-page":"390","article-title":"Herpes zoster ophthalmicus: report of cases and a review of the literature","volume":"40","author":"Edgerton AE","year":"1942","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_2_6_6_1","volume-title":"Neuroophthalmology","author":"Glaser JS","year":"1990"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/003693300505000113"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.61.11.677"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1991.23"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1258\/rsmsmj.52.4.54d"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2011.25"},{"key":"e_1_2_6_12_1","first-page":"149","article-title":"Sixth nerve palsy as the presenting sign of metastatic prostate cancer: a case report and review of the literature","volume":"12","author":"O\u2019Boyle JE","year":"1992","journal-title":"J Clin Neuroophthalmol"},{"key":"e_1_2_6_13_1","first-page":"52","article-title":"Diplopia as a presenting symptom","volume":"30","author":"Yapp JMS","year":"1973","journal-title":"Br Orthopt J"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.12062","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.12062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T16:36:07Z","timestamp":1695486967000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.12062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,7]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/aos.12062"],"URL":"https:\/\/doi.org\/10.1111\/aos.12062","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,7]]},"assertion":[{"value":"2013-02-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}