{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:44:57Z","timestamp":1788965097618,"version":"build-2803163510"},"reference-count":331,"publisher":"Wiley","issue":"thesis2","license":[{"start":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T00:00:00Z","timestamp":1362614400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec><jats:title>Abstract.<\/jats:title><\/jats:sec><jats:sec><jats:title>Purpose:<\/jats:title><jats:p>Malfunction of retinal blood flow or oxygenation is believed to be involved in various diseases. Among them are retinal vessel occlusions, diabetic retinopathy and glaucoma. Reliable, non\u2010invasive technology for retinal oxygen measurements has been scarce and most of the knowledge on retinal oxygenation comes from animal studies. This thesis describes human retinal oximetry, performed with novel retinal oximetry technology. The thesis describes studies on retinal vessel oxygen saturation in (1) light and dark in healthy volunteers, (2) central retinal vein occlusion, (3) branch retinal vein occlusion, (4) central retinal artery occlusion, (5) diabetic retinopathy, (6) patients undergoing glaucoma surgery and (7) patients taking glaucoma medication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>The retinal oximeter (Oxymap ehf., Reykjavik, Iceland) is based on a fundus camera. An attached image splitter allows the simultaneous capture of four images of the same area of the fundus. Two images are used for further analysis, one acquired with 586\u2003nm light and one with 605\u2003nm light. Light absorbance of retinal vessels is sensitive to oxygen saturation at 605\u2003nm but not at 586\u2003nm. Measurement of reflected light at these wavelengths allows estimation of oxygen saturation in the main retinal vessels. This is performed with custom\u2010made analysis software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><\/jats:sec><jats:sec><jats:title>Light and dark<\/jats:title><jats:p>After 30\u2003min in the dark, oxygen saturation in retinal arterioles of healthy volunteers was 92\u2003\u00b1\u20034% (mean\u2003\u00b1\u2003SD, <jats:italic>n<\/jats:italic>\u2003=\u200315). After 5\u2003min in 80\u2003cd\/m<jats:sup>2<\/jats:sup> light, the arteriolar saturation was 89\u2003\u00b1\u20035%. The decrease was statistically significant (p\u2003=\u20030.008). The corresponding values for retinal venules were 60\u2003\u00b1\u20035% in the dark and 55\u2003\u00b1\u200310% in the light (p\u2003=\u20030.020). Similar results were found after alternating 5\u2003min periods of darkness and light. In a second experiment (<jats:italic>n<\/jats:italic>\u2003=\u200319), a significant decrease in retinal vessel oxygen saturation was found in 100\u2003cd\/m<jats:sup>2<\/jats:sup> light compared with darkness but 1 and 10\u2003cd\/m<jats:sup>2<\/jats:sup> light had no significant effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Central retinal vein occlusion<\/jats:title><jats:p>In patients with central retinal vein occlusion, the mean saturation in affected retinal venules was 49\u2003\u00b1\u200312%, while the mean value for venules in the fellow eye was 65\u2003\u00b1\u20036% (mean\u2003\u00b1\u2003SD, p\u2003=\u20030.003, <jats:italic>n<\/jats:italic>\u2003=\u20038). The retinal arteriolar saturation was the same in affected (99\u2003\u00b1\u20033%) and the unaffected (99\u2003\u00b1\u20036%) eyes. The venous oxygen saturation showed much variation between affected eyes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Branch retinal vein occlusion<\/jats:title><jats:p>Median oxygen saturation in venules affected by branch retinal vein occlusion was 59% (range, 12\u201393%, <jats:italic>n<\/jats:italic>\u2003=\u200322), while it was 63% (23\u201380%) in unaffected venules in the affected eye and 55% (39\u201380%) in venules in the fellow eye. The difference was not statistically significant (p\u2003&gt;\u20030.05). There was a significant difference between affected arterioles (median 101%; range, 89\u2013115%) and unaffected arterioles (95%, 85\u2013104%) in the affected eye (p\u2003&lt;\u20030.05, <jats:italic>n<\/jats:italic>\u2003=\u200318).<\/jats:p><\/jats:sec><jats:sec><jats:title>Central retinal artery occlusion<\/jats:title><jats:p>In a patient with a day\u2019s history of central retinal artery occlusion due to temporal arteritis, the mean arteriolar saturation was 71\u2003\u00b1\u20039% and 63\u2003\u00b1\u20039% in the venules. One month later, after treatment with prednisolone, the mean arteriolar saturation was 100\u2003\u00b1\u20034% and the venous saturation 54\u2003\u00b1\u20035%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Diabetic retinopathy<\/jats:title><jats:p>When compared with healthy volunteers (<jats:italic>n<\/jats:italic>\u2003=\u200331), patients with all categories of diabetic retinopathy had on average 7\u201310 percentage points higher saturation in retinal arterioles (p\u2003&lt;\u20030.05 for all categories, <jats:italic>n<\/jats:italic>\u2003=\u20036\u20138 in each category). In venules, the saturation was 8\u201312 percentage points higher (p\u2003&lt;\u20030.05 for all categories).<\/jats:p><\/jats:sec><jats:sec><jats:title>Glaucoma surgery<\/jats:title><jats:p>Oxygen saturation in retinal arterioles increased by 2 percentage points on average (p\u2003=\u20030.046, <jats:italic>n<\/jats:italic>\u2003=\u200319) with surgery, which lowered intraocular pressure from 23\u2003\u00b1\u20037\u2003mmHg (mean\u2003\u00b1\u2003SD) to 10\u2003\u00b1\u20034\u2003mmHg (p\u2003&lt;\u20030.0001). No other significant changes were found (p\u2003\u2265\u20030.35).<\/jats:p><\/jats:sec><jats:sec><jats:title>Dorzolamide<\/jats:title><jats:p>A significant reduction of 3 percentage points was found in arterioles (p\u2003&lt;\u20030.01) and venules (p\u2003&lt;\u20030.05) when patients with glaucoma or ocular hypertension changed from dorzolamide\u2013timolol combination eye drops to timolol alone (<jats:italic>n<\/jats:italic>\u2003=\u20036). No change was found in patients, who started on timolol and switched to the combination therapy (p\u2003&gt;\u20030.05, <jats:italic>n<\/jats:italic>\u2003=\u20037).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Dual wavelength oximetry can be used to non\u2010invasively measure retinal vessel oxygen saturation in health and disease. The results indicate that retinal vessel oxygen saturation is (1) increased in the dark, (2) lower in venules affected by central retinal vein occlusions, (3) variable in branch retinal vein occlusion, (4) lower in retinal arterioles in central retinal artery occlusion, (5) increased in diabetic retinopathy, (6\u20137) mildly affected by glaucoma surgery or dorzolamide.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12086","type":"journal-article","created":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T14:13:10Z","timestamp":1362665590000},"page":"1-47","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Retinal Oximetry"],"prefix":"10.1111","volume":"91","author":[{"given":"Sveinn Hakon","family":"Hardarson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,7]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"516","article-title":"Oxygen distribution in the macaque retina","volume":"34","author":"Ahmed J","year":"1993","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199412013312203"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02764310"},{"key":"e_1_2_7_5_1","first-page":"30","article-title":"The retinal oxygen profile in cats","volume":"24","author":"Alder VA","year":"1983","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_6_1","first-page":"1029","article-title":"PO2 profiles and oxygen consumption in cat retina with an occluded retinal circulation","volume":"31","author":"Alder VA","year":"1990","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00403282"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1970.tb04765.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1972.tb05177.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1972.tb05182.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(73)90186-3"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1177\/112067210101100108","article-title":"The effects of beta\u2010blockers on ocular blood flow in patients with primary open angle glaucoma: a color Doppler imaging study","volume":"11","author":"Altan\u2010Yaycioglu R","year":"2001","journal-title":"Eur J Ophthalmol"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.003772"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-03-00840.1992"},{"key":"e_1_2_7_15_1","first-page":"153","article-title":"Risk factors associated with branch vs. central retinal vein occlusion","volume":"21","author":"Appiah AP","year":"1989","journal-title":"Ann Ophthalmol"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.1998.760108.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2003.00122.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2006.01.016"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.58.4.344"},{"key":"e_1_2_7_20_1","first-page":"1019","article-title":"The influence of elevated intraocular pressure on vascular pressures in the cat retina","volume":"35","author":"Attariwala R","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_21_1","first-page":"2742","article-title":"The effect of acute experimental retinal vein occlusion on cat retinal vein pressures","volume":"38","author":"Attariwala R","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(98)00114-7"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6293"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.02-0881"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e328316bb6f"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.86.2.748"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/02713680601139192"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920310790274653"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2011.04.004"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp425"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2001.790505.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.048173"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003470170128"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1963.00960040786021"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00221.2007"},{"key":"e_1_2_7_36_1","first-page":"623","article-title":"[Treatment pattern and results in an outpatient population with type 2 diabetes in Iceland.]","volume":"90","author":"Bjoernsdottir S","year":"2004","journal-title":"Laeknabladid"},{"key":"e_1_2_7_37_1","first-page":"305","article-title":"Ocular oxygen consumption during vitreoperfusion in the cat","volume":"98","author":"Blair NP","year":"2000","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-011-1680-2"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.1997.tb00471.x"},{"key":"e_1_2_7_40_1","first-page":"523","article-title":"Retinal oxygen tension and the electroretinogram during arterial occlusion in the cat","volume":"36","author":"Braun RD","year":"1995","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_41_1","first-page":"542","article-title":"Oxygen consumption in the inner and outer retina of the cat","volume":"36","author":"Braun RD","year":"1995","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1987.tb07026.x"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.45.3.161"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365519609088624"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-0065"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1006\/mvre.1993.1013"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181c596c6"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31821ba2c4"},{"key":"e_1_2_7_49_1","first-page":"886","article-title":"Retinal blood flow changes in patients with insulin\u2010dependent diabetes mellitus and no diabetic retinopathy","volume":"37","author":"Bursell SE","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_50_1","first-page":"241","article-title":"The effect of trabeculectomy on ocular hemodynamics","volume":"99","author":"Cantor LB","year":"2001","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(94)90055-8"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90483-9"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.58.5.548"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.12.4.293"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1961.00960010368014"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.84.9.1045"},{"key":"e_1_2_7_57_1","first-page":"2307","article-title":"Light and choroidal PO2 modulation of intraretinal oxygen levels in an avascular retina","volume":"40","author":"Cringle SJ","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_58_1","first-page":"1922","article-title":"Intraretinal oxygen consumption in the rat in vivo","volume":"43","author":"Cringle SJ","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-30648"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(87)80002-7"},{"key":"e_1_2_7_61_1","unstructured":"Database of Human Hemoglobin Variants and Thalassemias(2011): Available at:http:\/\/globin.bx.psu.edu\/hbvar\/."},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.81.1.27"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1159\/000055622"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1364\/AO.27.001113"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1364\/AO.28.001061"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199707000-00009"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.1998.tb02464.x"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01197.2001"},{"issue":"2","key":"e_1_2_7_69_1","first-page":"832","article-title":"Oxygen transport impairment in diabetes","volume":"25","author":"Ditzel J","year":"1976","journal-title":"Diabetes"},{"key":"e_1_2_7_70_1","first-page":"1450","article-title":"Decreased nitric oxide production accounts for secondary arteriolar constriction after retinal branch vein occlusion","volume":"38","author":"Donati G","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_71_1","first-page":"1910","article-title":"Effect of nitroprusside on arteriolar constriction after retinal branch vein occlusion","volume":"39","author":"Donati G","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2007.01044.x"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00402a049"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09265-6"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1989.01070020060029"},{"key":"e_1_2_7_76_1","first-page":"42","article-title":"Adrenergic nerves to the eye and related structures in man and in the cynomolgus monkey (Macaca Irus)","volume":"5","author":"Ehinger B","year":"1966","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.01.040"},{"key":"e_1_2_7_78_1","first-page":"1025","article-title":"Vitreous body oxygen tension following experimental branch retinal vein obstruction","volume":"18","author":"Ernest JT","year":"1979","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_79_1","first-page":"985","article-title":"Hyperglycemia impairs retinal oxygen autoregulation in normal and diabetic dogs","volume":"24","author":"Ernest JT","year":"1983","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.1999.15.479"},{"key":"e_1_2_7_81_1","first-page":"136","article-title":"Response of human retinal blood flow to light and dark","volume":"24","author":"Feke GT","year":"1983","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_82_1","first-page":"58","article-title":"Blood flow in the normal human retina","volume":"30","author":"Feke GT","year":"1989","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_83_1","volume-title":"A manual of laboratory and diagnostic tests","author":"Fischbach FT","year":"2009"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(02)00008-3"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01775-X"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1982.01030040110020"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6989(01)00171-7"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6989(03)00332-8"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.067637"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1994.66"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00941724"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-2510"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1159\/000048311"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1245117"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-9912"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0764"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-1016"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2007.01.001"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1006\/mvre.1993.1015"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)73526-3"},{"key":"e_1_2_7_101_1","first-page":"371","article-title":"Central retinal vein occlusion: a prospective histopathologic study of 29 eyes in 28 cases","volume":"79","author":"Green WR","year":"1981","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2007.08.010"},{"key":"e_1_2_7_103_1","first-page":"1713","article-title":"Effect of topical timolol on the human retinal circulation","volume":"27","author":"Grunwald JE","year":"1986","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_104_1","first-page":"521","article-title":"Effect of timolol maleate on the retinal circulation of human eyes with ocular hypertension","volume":"31","author":"Grunwald JE","year":"1990","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(84)34124-0"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713688408997205"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(87)33257-9"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01716-5"},{"key":"e_1_2_7_109_1","first-page":"755","article-title":"[Clinical status and treatment adherence of young adults with type one diabetes mellitus following transition to adult health care]","volume":"95","author":"Halldorsdottir H","year":"2009","journal-title":"Laeknabladid"},{"key":"e_1_2_7_110_1","first-page":"1045","article-title":"Experimental venous occlusion","volume":"67","author":"Hamilton AM","year":"1974","journal-title":"Proc R Soc Med"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.63.6.377"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.1364\/AO.37.007410"},{"key":"e_1_2_7_113_1","doi-asserted-by":"publisher","DOI":"10.1109\/10.918598"},{"key":"e_1_2_7_114_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/47\/17\/403"},{"key":"e_1_2_7_115_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.2976032"},{"key":"e_1_2_7_116_1","volume-title":"A new imaging technique for retinal vessel oximetry: principles and first clinical results in patients with retinal arterial occlusion and diabetic retinopathy","author":"Hammer M","year":"2009"},{"key":"e_1_2_7_117_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-009-1078-6"},{"key":"e_1_2_7_118_1","article-title":"Retinal oxygenation in diabetic retinopathy [ARVO conference abstract]","volume":"52","author":"Hardarson SH","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_119_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0039"},{"key":"e_1_2_7_120_1","doi-asserted-by":"publisher","DOI":"10.1113\/eph8802580"},{"key":"e_1_2_7_121_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.80.3.209"},{"key":"e_1_2_7_122_1","doi-asserted-by":"publisher","DOI":"10.3928\/1542-8877-20030301-16"},{"key":"e_1_2_7_123_1","doi-asserted-by":"publisher","DOI":"10.1117\/12.604609"},{"key":"e_1_2_7_124_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02368415"},{"key":"e_1_2_7_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4835(95)80060-3"},{"key":"e_1_2_7_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4835(95)80059-X"},{"key":"e_1_2_7_127_1","first-page":"1850","article-title":"Human ocular vasodynamic changes in light and darkness","volume":"40","author":"Havelius U","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_128_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.59.11.631"},{"key":"e_1_2_7_129_1","first-page":"3","volume-title":"Current concepts on ocular blood flow in glaucoma","author":"Hayreh SS","year":"1999"},{"key":"e_1_2_7_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2004.12.001"},{"key":"e_1_2_7_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2011.05.001"},{"key":"e_1_2_7_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00384-6"},{"key":"e_1_2_7_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.03.038"},{"key":"e_1_2_7_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)70001-7"},{"key":"e_1_2_7_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4835(03)00214-8"},{"key":"e_1_2_7_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.03.006"},{"key":"e_1_2_7_137_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.51.2.115"},{"key":"e_1_2_7_138_1","first-page":"34","article-title":"Studies of retinal circulation and A\u2010V oxygen difference in man","volume":"71","author":"Hickam JB","year":"1959","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"e_1_2_7_139_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.60.10.694"},{"key":"e_1_2_7_140_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.63.6.393"},{"key":"e_1_2_7_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.09.046"},{"key":"e_1_2_7_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.01.016"},{"key":"e_1_2_7_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.06.079"},{"key":"e_1_2_7_144_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-0176"},{"key":"e_1_2_7_145_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-010-0841-x"},{"key":"e_1_2_7_146_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.78.11.818"},{"key":"e_1_2_7_147_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.2434950"},{"key":"e_1_2_7_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.09.019"},{"key":"e_1_2_7_149_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2009.01557.x"},{"key":"e_1_2_7_150_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1976.03910040227015"},{"key":"e_1_2_7_151_1","doi-asserted-by":"publisher","DOI":"10.3341\/kjo.1995.9.2.107"},{"key":"e_1_2_7_152_1","article-title":"Counter\u2010current oxygen flux from arterioles to venules in the human retinal circulation [ARVO conference abstract]","volume":"48","author":"Karlsson RA","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_153_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024482"},{"key":"e_1_2_7_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2008.09.003"},{"key":"e_1_2_7_155_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-1069"},{"key":"e_1_2_7_156_1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2010.0150"},{"key":"e_1_2_7_157_1","first-page":"2399","article-title":"Autoregulation of choroidal blood flow in the rabbit","volume":"33","author":"Kiel JW","year":"1992","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_158_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2003.021857"},{"key":"e_1_2_7_159_1","doi-asserted-by":"publisher","DOI":"10.1159\/000268008"},{"key":"e_1_2_7_160_1","first-page":"133","article-title":"The epidemiology of retinal vein occlusion: the Beaver Dam Eye Study","volume":"98","author":"Klein R","year":"2000","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_2_7_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.03.028"},{"key":"e_1_2_7_162_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.307.6913.1195"},{"key":"e_1_2_7_163_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2010.02290.x"},{"key":"e_1_2_7_164_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.81.4.274"},{"key":"e_1_2_7_165_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103561"},{"key":"e_1_2_7_166_1","doi-asserted-by":"publisher","DOI":"10.1017\/S095252380623339X"},{"key":"e_1_2_7_167_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1963.00960040498013"},{"key":"e_1_2_7_168_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.61.4.278"},{"key":"e_1_2_7_169_1","unstructured":"LaingRA DanischLA&YoungR(1969):Non\u2010invasive multichromatic eye oximeter. Available at:http:\/\/www.archive.org\/details\/nasa_techdoc_19700011123."},{"key":"e_1_2_7_170_1","first-page":"606","article-title":"Photographic measurements of retinal blood oxygen saturation: falling saturation rabbit experiments","volume":"14","author":"Laing RA","year":"1975","journal-title":"Invest Ophthalmol"},{"key":"e_1_2_7_171_1","first-page":"528","article-title":"Retinal oxygenation via the choroidal circulation","volume":"76","author":"Landers MB","year":"1978","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_2_7_172_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-198200230-00007"},{"key":"e_1_2_7_173_1","doi-asserted-by":"publisher","DOI":"10.1159\/000331418"},{"key":"e_1_2_7_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.02.014"},{"key":"e_1_2_7_175_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1967.00980020407021"},{"key":"e_1_2_7_176_1","first-page":"45","volume-title":"The 6th international conference on photonics and imaging in biology and medicine","author":"Lazareva EN","year":"2007"},{"key":"e_1_2_7_177_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.88.4.521"},{"key":"e_1_2_7_178_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.99.2.177"},{"key":"e_1_2_7_179_1","first-page":"612","article-title":"Effects of hyperoxia on the oxygen distribution in the intact cat retina","volume":"30","author":"Linsenmeier RA","year":"1989","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_180_1","first-page":"1647","article-title":"Retinal hypoxia in long\u2010term diabetic cats","volume":"39","author":"Linsenmeier RA","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2010.06.034"},{"key":"e_1_2_7_182_1","first-page":"2678","article-title":"Subfoveal choroidal blood flow in response to light\u2010dark exposure","volume":"41","author":"Longo A","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_183_1","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200102000-00004"},{"key":"e_1_2_7_184_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.1996.tb01585.x"},{"key":"e_1_2_7_185_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02343050"},{"key":"e_1_2_7_186_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2009.01779.x"},{"key":"e_1_2_7_187_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2009.01796.x"},{"key":"e_1_2_7_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4835(05)80122-8"},{"key":"e_1_2_7_189_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2005.00631.x"},{"key":"e_1_2_7_190_1","first-page":"920","article-title":"[Experimental retinal branch vein occlusion. 4. Pathological changes in the middle and late stage]","volume":"97","author":"Minamikawa M","year":"1993","journal-title":"Nippon Ganka Gakkai Zasshi"},{"key":"e_1_2_7_191_1","first-page":"1410","article-title":"Effect of laser photocoagulation on oxygenation of the retina in miniature pigs","volume":"26","author":"Molnar I","year":"1985","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_192_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2010.222"},{"key":"e_1_2_7_193_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6217"},{"key":"e_1_2_7_194_1","doi-asserted-by":"publisher","DOI":"10.1006\/mvre.1997.2010"},{"key":"e_1_2_7_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(91)90106-O"},{"key":"e_1_2_7_196_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.10.1477"},{"key":"e_1_2_7_197_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5364"},{"key":"e_1_2_7_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2010.10.004"},{"key":"e_1_2_7_199_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0557"},{"key":"e_1_2_7_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2009.12.002"},{"key":"e_1_2_7_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)70374-5"},{"key":"e_1_2_7_202_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-0508"},{"key":"e_1_2_7_203_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2008.01318.x"},{"key":"e_1_2_7_204_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2008.146597"},{"key":"e_1_2_7_205_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.04.006"},{"key":"e_1_2_7_206_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31821801de"},{"key":"e_1_2_7_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(90)90213-E"},{"key":"e_1_2_7_208_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6985"},{"key":"e_1_2_7_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(80)90280-9"},{"key":"e_1_2_7_210_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0860689"},{"key":"e_1_2_7_211_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2003.041251"},{"key":"e_1_2_7_212_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-003-0817-3"},{"key":"e_1_2_7_213_1","doi-asserted-by":"publisher","DOI":"10.3129\/i08-049"},{"key":"e_1_2_7_214_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0502"},{"issue":"1","key":"e_1_2_7_215_1","first-page":"178","article-title":"Collateral vessels in branch retinal vein occlusion","volume":"102","author":"Pieris SJ","year":"1982","journal-title":"Trans Ophthalmol Soc U K"},{"key":"e_1_2_7_216_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1975.38.2.315"},{"key":"e_1_2_7_217_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-0307"},{"key":"e_1_2_7_218_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-199515040-00011"},{"key":"e_1_2_7_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(89)90045-6"},{"key":"e_1_2_7_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(90)32415-6"},{"key":"e_1_2_7_221_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(90)32414-4"},{"key":"e_1_2_7_222_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02764308"},{"key":"e_1_2_7_223_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1997.01100160723009"},{"key":"e_1_2_7_224_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0086"},{"key":"e_1_2_7_225_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2008.02.002"},{"key":"e_1_2_7_226_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2008.01366.x"},{"key":"e_1_2_7_227_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61423-7"},{"key":"e_1_2_7_228_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr120"},{"key":"e_1_2_7_229_1","doi-asserted-by":"publisher","DOI":"10.1109\/JSTQE.2007.911312"},{"key":"e_1_2_7_230_1","doi-asserted-by":"publisher","DOI":"10.1364\/OE.16.006170"},{"key":"e_1_2_7_231_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2007.01167.x"},{"key":"e_1_2_7_232_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.77.3.317"},{"key":"e_1_2_7_233_1","first-page":"737","article-title":"Reactivity of the human retinal circulation to darkness: a laser Doppler velocimetry study","volume":"24","author":"Riva CE","year":"1983","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_234_1","first-page":"47","article-title":"Laser Doppler Velocimetry study of the effect of pure oxygen breathing on retinal blood flow","volume":"24","author":"Riva CE","year":"1983","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_235_1","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1152\/jappl.1986.61.2.592","article-title":"Regulation of local oxygen tension and blood flow in the inner retina during hyperoxia","volume":"61","author":"Riva CE","year":"1986","journal-title":"J Appl Physiol"},{"key":"e_1_2_7_236_1","first-page":"211","article-title":"Near infrared retinal laser Doppler velocimetry","volume":"1","author":"Riva CE","year":"1987","journal-title":"Lasers Ophthalmol"},{"key":"e_1_2_7_237_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2004.07.002"},{"key":"e_1_2_7_238_1","doi-asserted-by":"publisher","DOI":"10.1016\/0268-960X(94)90109-0"},{"key":"e_1_2_7_239_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2010.514659"},{"key":"e_1_2_7_240_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3420417"},{"key":"e_1_2_7_241_1","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.23.4.298.5448"},{"key":"e_1_2_7_242_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-04-078188"},{"key":"e_1_2_7_243_1","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.2337\/diab.46.11.1868","article-title":"Renal and ocular hemodynamic effects of insulin","volume":"46","author":"Schmetterer L","year":"1997","journal-title":"Diabetes"},{"key":"e_1_2_7_244_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(97)90138-7"},{"key":"e_1_2_7_245_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2010.09.002"},{"key":"e_1_2_7_246_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-7491"},{"key":"e_1_2_7_247_1","doi-asserted-by":"publisher","DOI":"10.1117\/12.209850"},{"key":"e_1_2_7_248_1","doi-asserted-by":"publisher","DOI":"10.1109\/10.804573"},{"key":"e_1_2_7_249_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1014458815482"},{"key":"e_1_2_7_250_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-963156"},{"key":"e_1_2_7_251_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1989.01070010228027"},{"key":"e_1_2_7_252_1","first-page":"192","article-title":"Type of arteriovenous crossing at site of branch retinal vein occlusion","volume":"36","author":"Sekimoto M","year":"1992","journal-title":"Jpn J Ophthalmol"},{"key":"e_1_2_7_253_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-011-9284-2"},{"key":"e_1_2_7_254_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4710"},{"key":"e_1_2_7_255_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1986.01050200091057"},{"key":"e_1_2_7_256_1","first-page":"3174","article-title":"Effect of acute increases in intraocular pressure on intravascular optic nerve head oxygen tension in cats","volume":"33","author":"Shonat RD","year":"1992","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_257_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5666"},{"key":"e_1_2_7_258_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.125187"},{"key":"e_1_2_7_259_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2008.06.002"},{"key":"e_1_2_7_260_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2009.01604.x"},{"key":"e_1_2_7_261_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2009.02.003"},{"key":"e_1_2_7_262_1","doi-asserted-by":"publisher","DOI":"10.1097\/SMJ.0b013e318232139f"},{"key":"e_1_2_7_263_1","doi-asserted-by":"publisher","DOI":"10.1364\/AO.39.001183"},{"key":"e_1_2_7_264_1","article-title":"Retinal vessel oximetry: toward absolute calibration","volume":"3908","author":"Smith MH","year":"2000","journal-title":"Proc SPIE"},{"key":"e_1_2_7_265_1","doi-asserted-by":"publisher","DOI":"10.1117\/12.429265"},{"key":"e_1_2_7_266_1","first-page":"561","volume-title":"Physiology","author":"Staub NC","year":"1998"},{"key":"e_1_2_7_267_1","volume-title":"Ocular oxygenation and neovascularization","author":"Stefansson E","year":"1981"},{"key":"e_1_2_7_268_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198801000-00002"},{"key":"e_1_2_7_269_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2006.04.005"},{"key":"e_1_2_7_270_1","first-page":"307","article-title":"Increased retinal oxygen supply following pan\u2010retinal photocoagulation and vitrectomy and lensectomy","volume":"79","author":"Stefansson E","year":"1981","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_2_7_271_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-198200230-00006"},{"key":"e_1_2_7_272_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(83)90159-8"},{"key":"e_1_2_7_273_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(86)90765-8"},{"key":"e_1_2_7_274_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(88)90034-6"},{"issue":"2","key":"e_1_2_7_275_1","first-page":"H1127","article-title":"Intraocular oxygen tension measured with a fiber\u2010optic sensor in normal and diabetic dogs","volume":"256","author":"Stefansson E","year":"1989","journal-title":"Am J Physiol"},{"key":"e_1_2_7_276_1","first-page":"284","article-title":"Vitrectomy prevents retinal hypoxia in branch retinal vein occlusion","volume":"31","author":"Stefansson E","year":"1990","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_277_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)75750-2"},{"key":"e_1_2_7_278_1","first-page":"2756","article-title":"Optic nerve oxygen tension in pigs and the effect of carbonic anhydrase inhibitors","volume":"40","author":"Stefansson E","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_279_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2004.09.001"},{"key":"e_1_2_7_280_1","doi-asserted-by":"publisher","DOI":"10.1089\/10807680152729220"},{"key":"e_1_2_7_281_1","first-page":"2165","article-title":"Hemoglobin A2: origin, evolution, and aftermath","volume":"78","author":"Steinberg MH","year":"1991","journal-title":"Blood"},{"key":"e_1_2_7_282_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.14.8.756"},{"key":"e_1_2_7_283_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.5.1798"},{"key":"e_1_2_7_284_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1990.tb01701.x"},{"key":"e_1_2_7_285_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-5155(00)00271-9"},{"key":"e_1_2_7_286_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(98)00069-5"},{"key":"e_1_2_7_287_1","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.16.11.1102.5101"},{"key":"e_1_2_7_288_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00541-8"},{"key":"e_1_2_7_289_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-011-1859-6"},{"key":"e_1_2_7_290_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.9.1348"},{"key":"e_1_2_7_291_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1997.01100150488006"},{"key":"e_1_2_7_292_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)71345-5"},{"key":"e_1_2_7_293_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1146554"},{"key":"e_1_2_7_294_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)71029-1"},{"key":"e_1_2_7_295_1","first-page":"988","article-title":"Preretinal oxygen changes in the rabbit under conditions of light and dark","volume":"29","author":"Tillis TN","year":"1988","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_296_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000278741.29274.e1"},{"key":"e_1_2_7_297_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1979.tb06409.x"},{"key":"e_1_2_7_298_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(13)31332-3"},{"key":"e_1_2_7_299_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01920167"},{"key":"e_1_2_7_300_1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/978-1-4684-3273-2_48","article-title":"Studies on retinal oxygenation","volume":"75","author":"Tsacopoulos M","year":"1976","journal-title":"Adv Exp Med Biol"},{"key":"e_1_2_7_301_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2002"},{"key":"e_1_2_7_302_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2011.07.032"},{"key":"e_1_2_7_303_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2008.08.020"},{"key":"e_1_2_7_304_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(98)00006-8"},{"key":"e_1_2_7_305_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(02)00558-5"},{"key":"e_1_2_7_306_1","first-page":"48","article-title":"Glucose metabolism in cat outer retina. Effects of light and hyperoxia","volume":"38","author":"Wang L","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_307_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.1997.00030.x"},{"key":"e_1_2_7_308_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.1997.00131.x"},{"key":"e_1_2_7_309_1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.1997.13.225"},{"key":"e_1_2_7_310_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)74554-4"},{"key":"e_1_2_7_311_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-9071.2001.00399.x"},{"key":"e_1_2_7_312_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6701476"},{"key":"e_1_2_7_313_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-009-1072-z"},{"key":"e_1_2_7_314_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-7433-6_9"},{"key":"e_1_2_7_315_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(88)90823-9"},{"key":"e_1_2_7_316_1","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1093\/clinchem\/34.4.750","article-title":"Effect of pH on the absorption spectrum of human oxyhemoglobin: a potential source of error in measuring the oxygen saturation of hemoglobin","volume":"34","author":"Wimberley PD","year":"1988","journal-title":"Clin Chem"},{"key":"e_1_2_7_317_1","first-page":"1625","volume-title":"The lung: scientific foundations","author":"Winslow RM","year":"1997"},{"key":"e_1_2_7_318_1","first-page":"49","article-title":"Retinal oxygenation from the choroid in hyperoxia","volume":"47","author":"Wolbarsht ML","year":"1987","journal-title":"Exp Biol"},{"key":"e_1_2_7_319_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.45.10.683"},{"key":"e_1_2_7_320_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.72.9.660"},{"key":"e_1_2_7_321_1","first-page":"1731","article-title":"Peptidergic innervation of the retinal vasculature and optic nerve head","volume":"31","author":"Ye XD","year":"1990","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_322_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01109-0"},{"key":"e_1_2_7_323_1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1159\/000267116","article-title":"Effect of timolol on human retinal, choroidal and optic nerve head circulation","volume":"23","author":"Yoshida A","year":"1991","journal-title":"Ophthalmic Res"},{"key":"e_1_2_7_324_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1998.216"},{"key":"e_1_2_7_325_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)01949-9"},{"key":"e_1_2_7_326_1","first-page":"2493","article-title":"The response of rat vitreal oxygen tension to stepwise increases in inspired percentage oxygen","volume":"31","author":"Yu DY","year":"1990","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_327_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0767"},{"key":"e_1_2_7_328_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-1197"},{"key":"e_1_2_7_329_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-004-0102-y"},{"key":"e_1_2_7_330_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(93)31633-7"},{"key":"e_1_2_7_331_1","volume-title":"Visible and near infrared absorption spectra of human and animal haemoglobin \u2013 determination and application","author":"Zijlstra WG","year":"2000"},{"key":"e_1_2_7_332_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(80)90106-2"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.12086","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.12086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T06:26:38Z","timestamp":1694586398000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.12086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":331,"journal-issue":{"issue":"thesis2","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1111\/aos.12086"],"URL":"https:\/\/doi.org\/10.1111\/aos.12086","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3]]},"assertion":[{"value":"2013-03-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}