{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:34:07Z","timestamp":1789659247926,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T00:00:00Z","timestamp":1366934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold>The purpose of this study was to assess the incidence of intraoperative floppy iris syndrome (IFIS) and the morphology of the corneal endothelium after cataract extraction in Caucasian male patients exposed to the \u03b1\u20101<jats:sub>a<\/jats:sub>adrenergic receptor antagonist tamsulosin.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold>In a clinical prospective study, 23 male patients (23 eyes) treated with tamsulosin due to benign prostatic hyperplasia and 25 male patients (25 eyes) with no tamsulosin treatment had cataract surgery. The divide\u2010and\u2010conquer technique was used with the Infinity OZil<jats:sup>\u00ae<\/jats:sup>machine. A combination of Healon and Healon5 was used in all patients, but the use of additional Vision Blue, iris retractors or intracameral phenylephrine in the tamsulosin group was at the discretion of the surgeon. The endothelial cell density, variation in endothelial cell size (CV), percentage of hexagonal cells and central corneal thickness (CCT) were recorded at baseline and at 3\u2003months postoperatively.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>In the tamsulosin\u2010treated group, 19 of 23 eyes (83%) developed IFIS, compared with no IFIS in the control group. Compared with the control group, the tamsulosin group showed significantly less dilatation at the start of the operation, significant miosis during surgery and significantly greater corneal endothelial cell loss 3\u2003months postoperatively (12% versus 3%; p\u2003&lt;\u20030.001).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold>Intraoperative floppy iris syndrome during cataract surgery is significantly associated with tamsulosin\u2010treated male patients. Patients on tamsulosin showed less preoperative dilatation, significant miosis during surgery, and had significantly greater postoperative endothelial cell loss compared with nontreated patients despite recommended precautions.<\/jats:p>","DOI":"10.1111\/aos.12140","type":"journal-article","created":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T04:47:00Z","timestamp":1366951620000},"page":"359-363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Corneal endothelial cell changes after cataract surgery in patients on systemic sympathetic \u03b1\u20101<sub>a<\/sub>antagonist medication (tamsulosin)"],"prefix":"10.1111","volume":"92","author":[{"given":"Allan","family":"Storr\u2010Paulsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper 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