{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T22:08:49Z","timestamp":1782252529958,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":798,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Ophthalmol"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1111\/aos.12149","type":"journal-article","created":{"date-parts":[[2013,6,25]],"date-time":"2013-06-25T07:45:21Z","timestamp":1372146321000},"page":"e516-e523","source":"Crossref","is-referenced-by-count":35,"title":["Gene polymorphisms of the<i>MMP1, MMP9, MMP12, IL-1\u03b2<\/i>and<i>TIMP1<\/i>and the risk of primary open-angle glaucoma"],"prefix":"10.1111","volume":"91","author":[{"given":"Lukasz","family":"Markiewicz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ireneusz","family":"Majsterek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Przybylowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukasz","family":"Dziki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Waszczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mira","family":"Gacek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kaminska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Szaflik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek P.","family":"Szaflik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,25]]},"reference":[{"key":"10.1111\/aos.12149-BIB1|cit1","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.exer.2008.01.013","article-title":"Extracellular matrix in the trabecular meshwork","volume":"86","author":"Acott","year":"2008","journal-title":"Exp Eye Res"},{"key":"10.1111\/aos.12149-BIB2|cit2","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/1098-1136(200103)33:3<205::AID-GLIA1019>3.0.CO;2-D","article-title":"Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human optic nerve head astrocytes","volume":"33","author":"Agapova","year":"2001","journal-title":"Glia"},{"key":"10.1111\/aos.12149-BIB3|cit3","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1001\/archopht.120.9.1189","article-title":"Variations in the myocilin gene in patients with open-angle glaucoma","volume":"120","author":"Alward","year":"2002","journal-title":"Arch Ophthalmol"},{"key":"10.1111\/aos.12149-BIB4|cit4","first-page":"CR369","article-title":"Meta-analysis of association between optineurin gene and primary open-angle glaucoma","volume":"16","author":"Cheng","year":"2010","journal-title":"Med Sci Monit"},{"key":"10.1111\/aos.12149-BIB5|cit5","doi-asserted-by":"crossref","first-page":"47461","DOI":"10.1074\/jbc.M204824200","article-title":"Deficiency in matrix metalloproteinase gelatinase B (MMP-9) protects against retinal ganglion cell death after optic nerve ligation","volume":"277","author":"Chintala","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1111\/aos.12149-BIB6|cit6","first-page":"431","article-title":"Expression profile of inflammatory cytokines in aqueous from glaucomatous eyes","volume":"18","author":"Chua","year":"2012","journal-title":"Mol Vis"},{"key":"10.1111\/aos.12149-BIB7|cit7","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1034\/j.1600-051X.2003.300202.x","article-title":"MMP-1 promoter polymorphism: association with chronic periodontitis severity in a Brazilian population","volume":"30","author":"De Souza","year":"2003","journal-title":"J Clin Periodontol"},{"key":"10.1111\/aos.12149-BIB8|cit8","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0945-053X(00)00059-7","article-title":"Rapid genotype analysis of the matrix metalloproteinase-1 gene 1G\/2G polymorphism that is associated with risk of cancer","volume":"19","author":"Dunleavey","year":"2000","journal-title":"Matrix Biol"},{"key":"10.1111\/aos.12149-BIB9|cit9","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S1350-9462(02)00008-3","article-title":"The impact of ocular blood flow in glaucoma","volume":"21","author":"Flammer","year":"2002","journal-title":"Prog Retin Eye Res"},{"key":"10.1111\/aos.12149-BIB10|cit10","doi-asserted-by":"crossref","first-page":"6296","DOI":"10.1074\/jbc.M107865200","article-title":"A single nucleotide polymorphism in the matrix metalloproteinase-1 (MMP-1) promoter influences amnion cell MMP-1 expression and risk for preterm premature rupture of the fetal membranes","volume":"277","author":"Fujimoto","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1111\/aos.12149-BIB11|cit11","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1167\/iovs.04-0832","article-title":"Retinal ganglion cell apoptosis in glaucoma is related to intraocular pressure and IOP-induced effects on extracellular matrix","volume":"46","author":"Guo","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1111\/aos.12149-BIB12|cit12","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S1350-9462(99)00017-8","article-title":"The optic nerve head in glaucoma: role of astrocytes in tissue remodeling","volume":"19","author":"Hernandez","year":"2000","journal-title":"Prog Retin Eye Res"},{"key":"10.1111\/aos.12149-BIB13|cit13","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1167\/iovs.06-1445","article-title":"Synergism of TNF and IL-1 in the induction of matrix metalloproteinase-3 in trabecular meshwork","volume":"48","author":"Kelley","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1111\/aos.12149-BIB14|cit14","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1161\/01.STR.0000099966.51485.5F","article-title":"Tissue inhibitor of metalloproteinases-1, -2, and -3 polymorphisms in a white population with intracranial aneurysms","volume":"34","author":"Krex","year":"2003","journal-title":"Stroke"},{"key":"10.1111\/aos.12149-BIB15|cit15","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/sj.bjc.6603307","article-title":"Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer","volume":"95","author":"Kubben","year":"2006","journal-title":"Br J Cancer"},{"key":"10.1111\/aos.12149-BIB16|cit16","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1056\/NEJMra0804630","article-title":"Primary open-angle glaucoma","volume":"360","author":"Kwon","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1111\/aos.12149-BIB17|cit17","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/01.ijg.0000145812.39224.0a","article-title":"Matrix metalloproteinases and their tissue inhibitors in aqueous humor of patients with primary open-angle glaucoma, exfoliation syndrome, and exfoliation glaucoma","volume":"14","author":"Maatta","year":"2005","journal-title":"J Glaucoma"},{"key":"10.1111\/aos.12149-BIB18|cit18","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/01.ijg.0000212229.57922.72","article-title":"Levels and activation of matrix metalloproteinases in aqueous humor are elevated in uveitis-related secondary glaucoma","volume":"15","author":"Maatta","year":"2006","journal-title":"J Glaucoma"},{"key":"10.1111\/aos.12149-BIB19|cit19","doi-asserted-by":"crossref","first-page":"CR417","DOI":"10.12659\/MSM.881854","article-title":"Association of MMP1-1607 1G\/2G and TIMP1 372 T\/C gene polymorphisms with risk of primary open angle glaucoma in a Polish population","volume":"17","author":"Majsterek","year":"2011","journal-title":"Med Sci Monit"},{"key":"10.1111\/aos.12149-BIB20|cit20","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/00055735-200312000-00006","article-title":"Neuroprotection in glaucoma: a model for neuroprotection in optic neuropathies","volume":"14","author":"Marcic","year":"2003","journal-title":"Curr Opin Ophthalmol"},{"key":"10.1111\/aos.12149-BIB21|cit21","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.3748\/wjg.v13.i21.2960","article-title":"Role of matrix metalloproteinase, tissue inhibitor of metalloproteinase and tumor necrosis factor-alpha single nucleotide gene polymorphisms in inflammatory bowel disease","volume":"13","author":"Meijer","year":"2007","journal-title":"World J Gastroenterol"},{"key":"10.1111\/aos.12149-BIB22|cit22","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/1471-2350-11-99","article-title":"Association of IL1A and IL1B loci with primary open angle glaucoma","volume":"11","author":"Mookherjee","year":"2010","journal-title":"BMC Med Genet"},{"key":"10.1111\/aos.12149-BIB23|cit23","first-page":"1764","article-title":"Role of functional single nucleotide polymorphisms of MMP1, MMP2, and MMP9 in open angle glaucoma","volume":"16","author":"Mossbock","year":"2010","journal-title":"Mol Vis"},{"key":"10.1111\/aos.12149-BIB24|cit24","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"Br J Ophthalmol"},{"key":"10.1111\/aos.12149-BIB25|cit25","first-page":"844","article-title":"Global data on visual impairment in the year 2002","volume":"82","author":"Resnikoff","year":"2004","journal-title":"Bull World Health Organ"},{"key":"10.1111\/aos.12149-BIB26|cit26","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s00417-006-0440-1","article-title":"Matrix metalloproteinases and their inhibitors in the chamber angle of normal eyes and patients with primary open-angle glaucoma and exfoliation glaucoma","volume":"245","author":"Ronkko","year":"2007","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1111\/aos.12149-BIB27|cit27","first-page":"5321","article-title":"A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter creates an Ets binding site and augments transcription","volume":"58","author":"Rutter","year":"1998","journal-title":"Cancer Res"},{"key":"10.1111\/aos.12149-BIB28|cit28","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1167\/iovs.02-0365","article-title":"Matrix metalloproteinases and their inhibitors in aqueous humor of patients with pseudoexfoliation syndrome\/glaucoma and primary open-angle glaucoma","volume":"44","author":"Schlotzer-Schrehardt","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1111\/aos.12149-BIB29|cit29","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1126\/science.275.5300.668","article-title":"Identification of a gene that causes primary open angle glaucoma","volume":"275","author":"Stone","year":"1997","journal-title":"Science"},{"key":"10.1111\/aos.12149-BIB30|cit30","first-page":"2890","article-title":"Evaluation of MMP1 and MMP3 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma","volume":"15","author":"Tsironi","year":"2009","journal-title":"Mol Vis"},{"key":"10.1111\/aos.12149-BIB31|cit31","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1161\/01.RES.0000070112.80711.3D","article-title":"Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry","volume":"92","author":"Visse","year":"2003","journal-title":"Circ Res"},{"key":"10.1111\/aos.12149-BIB32|cit32","first-page":"CR501","article-title":"Assessment of blood flow in posterior ciliary arteries and its correlation with intraocular and arterial blood pressures in patients with open angle glaucoma","volume":"16","author":"Waliszek-Iwanicka","year":"2010","journal-title":"Med Sci Monit"},{"key":"10.1111\/aos.12149-BIB33|cit33","first-page":"RA252","article-title":"Future possibilities in glaucoma therapy","volume":"16","author":"Wierzbowska","year":"2010","journal-title":"Med Sci Monit"},{"key":"10.1111\/aos.12149-BIB34|cit34","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/00041444-200209000-00006","article-title":"Genetic polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic Alzheimer\u2019s disease","volume":"12","author":"Wollmer","year":"2002","journal-title":"Psychiatr Genet"},{"key":"10.1111\/aos.12149-BIB35|cit35","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1001\/archopht.118.5.666","article-title":"Matrix metalloproteinases and tumor necrosis factor alpha in glaucomatous optic nerve head","volume":"118","author":"Yan","year":"2000","journal-title":"Arch Ophthalmol"},{"key":"10.1111\/aos.12149-BIB36|cit36","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.exer.2003.10.018","article-title":"Influence of interleukin-1 beta induction and mitogen-activated protein kinase phosphorylation on optic nerve ligation-induced matrix metalloproteinase-9 activation in the retina","volume":"78","author":"Zhang","year":"2004","journal-title":"Exp Eye Res"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.12149","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T11:11:37Z","timestamp":1498043497000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1111\/aos.12149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,25]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,11]]}},"URL":"https:\/\/doi.org\/10.1111\/aos.12149","relation":{},"ISSN":["1755-375X"],"issn-type":[{"value":"1755-375X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6,25]]}}}