{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:18:55Z","timestamp":1789773535536,"version":"4.0.1"},"reference-count":225,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T00:00:00Z","timestamp":1372723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p>Corneal wound healing is a complex process: its mechanisms and the underlying genetic control are not fully understood. It involves the integrated actions of multiple growth factors, cytokines and proteases produced by epithelial cells, stromal keratocytes, inflammatory cells and lacrimal gland cells. Following an epithelial insult, multiple cytokines are released triggering a cascade of events that leads to repair the epithelial defect and remodelling of the stroma to minimize the loss of transparency and function. In this review, we examine the literature surrounding the genomics of corneal wound healing with respect to the following topics: epithelial and stromal wound healing (including inhibition); corneal neovascularisation; the role of corneal nerves in wound healing; the endothelium; the role of aquaporins and aptamers. We also examine the effect of ectasia on corneal wound healing with regard to keratoconus and following corneal surgery. A better understanding of the cellular and molecular changes that occur during repair of corneal wounds will provide the opportunity to design treatments that selectively modulate key phases of the healing process resulting in scars that more closely resemble normal corneal architecture.<\/jats:p>","DOI":"10.1111\/aos.12227","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T13:29:59Z","timestamp":1372771799000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Genomics of corneal wound healing: a review of the literature"],"prefix":"10.1111","volume":"92","author":[{"given":"Nick J. R.","family":"Maycock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,2]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"18","article-title":"Requirement for vascular endothelial growth factor in wound\u2010 and inflammation\u2010related corneal neovascularization","volume":"39","author":"Amano S","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05249"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.17.1.79.5261"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.16.6.605.5081"},{"key":"e_1_2_6_6_1","first-page":"264","article-title":"Corneal angiogenic privilege: angiogenic and antiangiogenic factors in corneal avascularity, vasculogenesis and wound healing","volume":"104","author":"Azar D","year":"2006","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199601000-00005"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.116.9.1206"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31826ab0a7"},{"key":"e_1_2_6_10_1","first-page":"137","article-title":"Trigeminal ganglion neurons affect corneal epithelial phenotype: influence on type VII collagen expression in vitro","volume":"34","author":"Baker KS","year":"1993","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2002.800303.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0185"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2010.06.023"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2011.12.022"},{"key":"e_1_2_6_15_1","first-page":"2293","article-title":"Superoxide dismutase isoenzymes in the normal and diseased human cornea","volume":"42","author":"Behndig A","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_16_1","first-page":"471","article-title":"Superoxide dismutase isoenzymes in the human eye","volume":"39","author":"Behndig A","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1998.0512"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80797-4"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80589-6"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1997.0342a.x"},{"key":"e_1_2_6_21_1","first-page":"55","volume-title":"Acta Ophthalmol Suppl","author":"Berman M","year":"1989"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(80)90154-5"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.7.1525"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-2382"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2003.012872"},{"key":"e_1_2_6_26_1","first-page":"336","article-title":"Human recombinant epidermal growth factor in experimental corneal wound healing","volume":"32","author":"Brazzell RK","year":"1991","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_27_1","unstructured":"BurdonKP LaurieKJ MillsRA CosterDJ MacGregorS&CraigJE(2010):a genome\u2010wide association scan for keratoconus identifies novel candidate genes. ARVO. Poster #4646 ."},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0496-376"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.1.82"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M009672200"},{"key":"e_1_2_6_31_1","first-page":"2897","article-title":"Detection of differentially expressed genes in healing mouse corneas, using cDNA microarrays","volume":"43","author":"Cao Z","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_32_1","first-page":"1422","article-title":"Delay of corneal epithelial wound healing and induction of keratocyte apoptosis by platelet\u2010activating factor","volume":"43","author":"Chandrasekher G","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.05.043"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(99)00251-8"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(01)00585-8"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.80.3.224"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2011.287"},{"key":"e_1_2_6_38_1","first-page":"464","article-title":"Epithelial wound closure in the rabbit cornea","volume":"27","author":"Crosson CE","year":"1986","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1159\/000099253"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3420249"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2006.03.015"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200005000-00002"},{"key":"e_1_2_6_43_1","first-page":"1112","article-title":"Correlation of VEGF expression by leukocytes with the growth and regression of blood vessels in the rat cornea","volume":"40","author":"Edelman JL","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-9071.2001.d01-16.x"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2010.01.002"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/112067219800800404"},{"key":"e_1_2_6_47_1","first-page":"317","article-title":"Dominantly inherited keratoconus","volume":"17","author":"Falls HF","year":"1969","journal-title":"J Genet Hum"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5688"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(98)00033-0"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1992.tb02165.x"},{"key":"e_1_2_6_51_1","first-page":"1287","article-title":"Role of matrix metalloproteinases in failure to re\u2010epithelialize after corneal injury","volume":"149","author":"Fini ME","year":"1996","journal-title":"Am J Pathol"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(72)90059-0"},{"key":"e_1_2_6_53_1","first-page":"59","article-title":"A role of transforming growth factor\u2010beta 1 in the control of corneal neovascularization","volume":"10","author":"Friling R","year":"1996","journal-title":"In Vivo"},{"key":"e_1_2_6_54_1","first-page":"120","article-title":"Fibronectin in healing rabbit corneal wounds","volume":"45","author":"Fujikawa LS","year":"1981","journal-title":"Lab Invest"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.98.1.128"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-002-0705-7"},{"key":"e_1_2_6_57_1","doi-asserted-by":"crossref","first-page":"S457","DOI":"10.3928\/1081-597X-19970801-20","article-title":"Effect of topical tranilast and corticosteroids on subepithelial haze after photorefractive keratectomy in rabbits","volume":"13","author":"Furukawa H","year":"1997","journal-title":"J Refract Surg"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.85.8.996"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-2173"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1994.1145"},{"key":"e_1_2_6_61_1","first-page":"161","article-title":"Actin filaments in normal and migrating corneal epithelial cells","volume":"16","author":"Gipson IK","year":"1977","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_62_1","first-page":"212","article-title":"Anchoring fibrils form a complex network in human and rabbit cornea","volume":"28","author":"Gipson IK","year":"1987","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(88)90136-4"},{"key":"e_1_2_6_64_1","first-page":"425","article-title":"Reassembly of the anchoring structures of the corneal epithelium during wound repair in the rabbit","volume":"30","author":"Gipson IK","year":"1989","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_65_1","first-page":"2441","article-title":"Transforming growth factor\u2010beta and interleukin\u20101 modulate metalloproteinase expression by corneal stromal cells","volume":"32","author":"Girard MT","year":"1991","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1050617"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2003.027573"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(77)90142-7"},{"key":"e_1_2_6_69_1","first-page":"3292","article-title":"Effects of epidermal growth factor, fibroblast growth factor, and transforming growth factor\u2010beta on corneal cell chemotaxis","volume":"33","author":"Grant MB","year":"1992","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M410638200"},{"key":"e_1_2_6_71_1","first-page":"906","article-title":"[Genetic aspects of keratoconus (author\u2019s transl)]","volume":"170","author":"Hallermann W","year":"1977","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"e_1_2_6_72_1","first-page":"629","article-title":"A novel locus for leber congenital amaurosis (LCA4) with anterior keratoconus mapping to chromosome 17p13","volume":"41","author":"Hameed A","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2000.6248"},{"key":"e_1_2_6_74_1","first-page":"276","article-title":"Keratocyte apoptosis after corneal surgery","volume":"39","author":"Helena MC","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.9.1029"},{"key":"e_1_2_6_76_1","first-page":"1309","article-title":"Repair in avascular tissues: fibrosis in the transparent structures of the eye and thrombospondin\u2010 1","volume":"14","author":"Hiscott P","year":"1999","journal-title":"Histol Histopathol"},{"key":"e_1_2_6_77_1","first-page":"804","article-title":"Kinetics of corneal epithelial regeneration and epidermal growth factor","volume":"13","author":"Ho PC","year":"1974","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1997.0338"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(00)00835-X"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0399"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.022103"},{"key":"e_1_2_6_82_1","first-page":"1","article-title":"Clinical and epidemiological features of keratoconus genetic and external factors in the pathogenesis of the disease","volume":"178","author":"Ihalainen A","year":"1986","journal-title":"Acta Ophthalmol Suppl"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(99)00007-5"},{"key":"e_1_2_6_84_1","first-page":"2313","article-title":"The effect of hyaluronic acid on corneal epithelial cell proliferation","volume":"34","author":"Inoue M","year":"1993","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.10.1272"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199703000-00010"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4835(03)00188-X"},{"issue":"5","key":"e_1_2_6_88_1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1242\/jcs.112.5.613","article-title":"The cellular basis of corneal transparency: evidence for \u2018corneal crystallins","volume":"112","author":"Jester JV","year":"1999","journal-title":"J Cell Sci"},{"key":"e_1_2_6_89_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3928\/1081-597X-19980101-09","article-title":"Removal of corneal epithelium with phototherapeutic technique during multi\u2010zone, multi\u2010pass, photorefractive keratectomy","volume":"14","author":"Johnson DG","year":"1998","journal-title":"J Refract Surg"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1997.0446"},{"key":"e_1_2_6_91_1","first-page":"2535","article-title":"Sympathetic stimulation of corneal epithelial proliferation in wounded and nonwounded rat eyes","volume":"37","author":"Jones MA","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713689508998408"},{"key":"e_1_2_6_93_1","first-page":"1294","article-title":"Corneal endothelial repair. Regulation of prostaglandin E2 synthesis","volume":"37","author":"Jumblatt MM","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_94_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.82.4.456g"},{"key":"e_1_2_6_95_1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/00003226-199805000-00013","article-title":"Effects of PDGF on the migration of rabbit corneal fibroblasts and epithelial cells","volume":"17","author":"Kamiyama K","year":"1998","journal-title":"Cornea"},{"key":"e_1_2_6_96_1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1242\/dev.112.2.605","article-title":"Tenascin Mr 220,000 isoform expression correlates with corneal cell migration","volume":"112","author":"Kaplony A","year":"1991","journal-title":"Development"},{"key":"e_1_2_6_97_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.01-1257"},{"key":"e_1_2_6_98_1","first-page":"481","article-title":"Indirect mitogenic effect of transforming growth factor\u2010beta on cell proliferation of subconjunctival fibroblasts","volume":"39","author":"Kay EP","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_99_1","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.17.3.286.5212"},{"key":"e_1_2_6_100_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6199"},{"key":"e_1_2_6_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1367-0484(03)00022-5"},{"key":"e_1_2_6_102_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199705000-00016"},{"key":"e_1_2_6_103_1","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1997.0292"},{"key":"e_1_2_6_104_1","unstructured":"KhanYM AngunawelaR BunkaD StockelyP&MarshallJ(2007):Targeting activated corneal keratocytes through CD90 specific RNA aptamers: potential for addressing early loss of corneal transparency.ARVO1477\u2010B971 ."},{"key":"e_1_2_6_105_1","unstructured":"KhanYM AngunawelaR BunkaD StockelyP&MarshallJ(2008):Aptamer based selective targeting of keratocytes: next generation therapeutics for corneal wound management.ARVO2945\u2010A197 ."},{"key":"e_1_2_6_106_1","first-page":"1364","article-title":"Effect of PDGF, IL\u20101\u2010alpha, and BMP2\/4 on corneal fibroblast chemotaxis: expression of the platelet\u2010derived growth factor system in the cornea","volume":"40","author":"Kim WJ","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_107_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2004.19.4.591"},{"key":"e_1_2_6_108_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4937"},{"key":"e_1_2_6_109_1","first-page":"1773","article-title":"The mechanism of accelerated corneal epithelial healing by human epidermal growth factor","volume":"31","author":"Kirazowa T","year":"1990","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_110_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713688509025145"},{"key":"e_1_2_6_111_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.01-1058"},{"key":"e_1_2_6_112_1","first-page":"4","article-title":"Sliding of the epithelium in experimental corneal wounds","volume":"15","author":"Kuwabara T","year":"1976","journal-title":"Invest Ophthalmol"},{"key":"e_1_2_6_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2009.11.013"},{"key":"e_1_2_6_114_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0214"},{"key":"e_1_2_6_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-0124(12)70128-3"},{"key":"e_1_2_6_116_1","first-page":"393","article-title":"Effect of myopic LASIK on corneal sensitivity and morphology of subbasal nerves","volume":"41","author":"Linna TU","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_117_1","first-page":"1887","article-title":"Molecular analysis of the VSX1 gene in familial keratoconus","volume":"13","author":"Liskova P","year":"2007","journal-title":"Mol Vis"},{"key":"e_1_2_6_118_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2010.200"},{"key":"e_1_2_6_119_1","first-page":"997","article-title":"Extracellular matrix alterations in human corneas with bullous keratopathy","volume":"37","author":"Ljubimov AV","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_120_1","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1998.0511"},{"key":"e_1_2_6_121_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.1996.tb01596.x"},{"key":"e_1_2_6_122_1","first-page":"20","article-title":"Immunolocalization and gene expression of matrilysin during corneal wound healing","volume":"40","author":"Lu P","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_123_1","doi-asserted-by":"publisher","DOI":"10.1177\/153537020222600711"},{"key":"e_1_2_6_124_1","first-page":"1696","article-title":"Increased platelet\u2010activating factor receptor gene expression by corneal epithelial wound healing","volume":"41","author":"Ma X","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_125_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200201000-00020"},{"key":"e_1_2_6_126_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199709000-00016"},{"key":"e_1_2_6_127_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.24.7634"},{"key":"e_1_2_6_128_1","first-page":"1555","article-title":"Expression of macrophage migration inhibitory factor in corneal wound healing in rats","volume":"38","author":"Matsuda A","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_129_1","first-page":"1071","article-title":"Corneal wound healing in tenascin knockout mouse","volume":"40","author":"Matsuda A","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2007.02.013"},{"key":"e_1_2_6_131_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1957.sp005758"},{"key":"e_1_2_6_132_1","first-page":"489","volume-title":"The eye (Chapter 7)","author":"Maurice DM","year":"1969"},{"key":"e_1_2_6_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)63504-5"},{"key":"e_1_2_6_134_1","first-page":"65","article-title":"The effect of denervation and the stimulation of the sympathetic and trigeminal nerve on the mitotic rate of the corneal epithelium in the rabbit","volume":"1","author":"Mishima S","year":"1957","journal-title":"Jpn J Ophthalmol"},{"key":"e_1_2_6_135_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713689209000742"},{"key":"e_1_2_6_136_1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.1990.6.91"},{"key":"e_1_2_6_137_1","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.17.7.736.5163"},{"key":"e_1_2_6_138_1","doi-asserted-by":"publisher","DOI":"10.1159\/000134209"},{"key":"e_1_2_6_139_1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3928\/1081-597X-19970701-11","article-title":"Effect of transforming growth factor beta 1 on stromal haze following excimer laser photorefractive keratectomy in rabbits","volume":"13","author":"Myers JS","year":"1997","journal-title":"J Refract Surg"},{"key":"e_1_2_6_140_1","first-page":"17","article-title":"The effect of epidermal growth factor on corneal endothelial wound healing in rabbits","volume":"99","author":"Nakahori Y","year":"1995","journal-title":"Acta Soc Ophthalmol Jpn"},{"key":"e_1_2_6_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2005.09.021"},{"key":"e_1_2_6_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-0124(12)70206-9"},{"key":"e_1_2_6_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(91)90110-Z"},{"key":"e_1_2_6_144_1","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1997.0419"},{"key":"e_1_2_6_145_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-9233.75876"},{"key":"e_1_2_6_146_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713689609017623"},{"key":"e_1_2_6_147_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200303000-00008"},{"key":"e_1_2_6_148_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004170050034"},{"key":"e_1_2_6_149_1","first-page":"355","article-title":"Cell surface glycoproteins of corneal epithelium","volume":"36","author":"Panjwani N","year":"1995","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_150_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-007-0357-5"},{"key":"e_1_2_6_151_1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3928\/1081-597X-19960101-31","article-title":"Videokeratography of keratoconus in monozygotic twins","volume":"12","author":"Parker J","year":"1996","journal-title":"J Refract Surg"},{"key":"e_1_2_6_152_1","first-page":"995","article-title":"Confocal microscopy in vivo in corneas of long\u2010term contact lens wearers","volume":"43","author":"Patel SV","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_153_1","first-page":"577","article-title":"High molecular weight hyaluronan decreases UVB\u2010induced apoptosis and inflammation in human epithelial corneal cells","volume":"15","author":"Pauloin T","year":"2009","journal-title":"Mol Vis"},{"key":"e_1_2_6_154_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713688409003059"},{"key":"e_1_2_6_155_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200111000-00015"},{"key":"e_1_2_6_156_1","doi-asserted-by":"publisher","DOI":"10.3109\/09273949709085057"},{"key":"e_1_2_6_157_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1993.tb18008.x"},{"key":"e_1_2_6_158_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713689508995127"},{"key":"e_1_2_6_159_1","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1997.0455"},{"key":"e_1_2_6_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(97)00119-7"},{"key":"e_1_2_6_161_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-1028"},{"key":"e_1_2_6_162_1","first-page":"2915","article-title":"Corneal structure and sensitivity in type 1 diabetes mellitus","volume":"41","author":"Rosenberg ME","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_163_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-007-0455-0"},{"key":"e_1_2_6_164_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwp133"},{"key":"e_1_2_6_165_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240450407"},{"key":"e_1_2_6_166_1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1755-3768.1992.tb02170.x","article-title":"Effects of growth factors on corneal wound healing","volume":"202","author":"Schultz G","year":"1992","journal-title":"Acta Ophthalmol Scand"},{"key":"e_1_2_6_167_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00137945"},{"key":"e_1_2_6_168_1","first-page":"1538","article-title":"Effect of down\u2010regulation of aquaporins in human corneal endothelial and epithelial cell lines","volume":"16","author":"Shankardas J","year":"2010","journal-title":"Mol Vis"},{"key":"e_1_2_6_169_1","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.16.3.183.15403"},{"key":"e_1_2_6_170_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1954.00920050048005"},{"key":"e_1_2_6_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)74397-1"},{"key":"e_1_2_6_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2011.09.012"},{"key":"e_1_2_6_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(01)00015-5"},{"key":"e_1_2_6_174_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.202235299"},{"key":"e_1_2_6_175_1","first-page":"1524","article-title":"Keratinocyte growth factor accelerates corneal epithelial wound healing in vivo","volume":"36","author":"Sotozani C","year":"1995","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_176_1","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.16.7.670.5057"},{"key":"e_1_2_6_177_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00128"},{"key":"e_1_2_6_178_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.02-1188"},{"key":"e_1_2_6_179_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2012.157"},{"key":"e_1_2_6_180_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1990.01070130106039"},{"key":"e_1_2_6_181_1","first-page":"117","article-title":"Mannose 6 phosphate reduces haze following excimer laser photorefractive keratectomy","volume":"7","author":"Sutton G","year":"1996","journal-title":"Lasers Light Ophthalmol"},{"key":"e_1_2_6_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(02)00042-3"},{"key":"e_1_2_6_183_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.GIM.0000170772.41860.54"},{"key":"e_1_2_6_184_1","first-page":"2395","article-title":"VSX1 gene analysis in keratoconus","volume":"16","author":"Tanwar M","year":"2010","journal-title":"Mol Vis"},{"key":"e_1_2_6_185_1","first-page":"2912","article-title":"Expression of tenascin and cellular fibronectin in the rabbit cornea after anterior keratectomy. Immunohistochemical study of wound healing dynamics","volume":"32","author":"Tervo K","year":"1991","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_186_1","first-page":"1442","article-title":"The X, Y, Z hypothesis of corneal epithelial maintenance","volume":"24","author":"Thoft RA","year":"1983","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(97)80110-1"},{"key":"e_1_2_6_188_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.58.223"},{"key":"e_1_2_6_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(90)90127-H"},{"key":"e_1_2_6_190_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.77.4.243"},{"key":"e_1_2_6_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2008.03.002"},{"key":"e_1_2_6_192_1","doi-asserted-by":"publisher","DOI":"10.1006\/exer.2001.0999"},{"key":"e_1_2_6_193_1","first-page":"3160","article-title":"A locus for autosomal dominant keratoconus: linkage to 16q22.3\u2010q23.1 in Finnish families","volume":"43","author":"Tyynismaa H","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_194_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-0548"},{"key":"e_1_2_6_195_1","first-page":"1772","article-title":"Microarray analysis of gene expression patterns during healing of rat corneas after excimer laser photorefractive keratectomy","volume":"43","author":"Varela JC","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_196_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02519"},{"key":"e_1_2_6_197_1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1177\/112067219700700404","article-title":"A comparative study of the duration and efficacy of tetracaine 1% and bupivacaine 0.75% in controlling pain following PRK","volume":"7","author":"Verma S","year":"1997","journal-title":"Eur J Ophthalmol"},{"key":"e_1_2_6_198_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.6.1039"},{"key":"e_1_2_6_199_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20000828)93:5<403::AID-AJMG11>3.0.CO;2-A"},{"key":"e_1_2_6_200_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-198036"},{"key":"e_1_2_6_201_1","first-page":"1543","article-title":"Hepatocyte growth factor, keratinocyte growth factor and other growth factor\u2010receptor systems in the lens","volume":"38","author":"Weng J","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_202_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199707000-00015"},{"key":"e_1_2_6_203_1","first-page":"1367","article-title":"Repair phenotype in corneal fibroblasts is controlled by an interleukin\u20101 alpha autocrine feedback loop","volume":"38","author":"West\u2010Mays JA","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_204_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200005001-00003"},{"key":"e_1_2_6_205_1","first-page":"220","article-title":"Keratocyte apoptosis: implications on corneal wound healing, tissue organization, and disease","volume":"39","author":"Wilson SE","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_206_1","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1998.0603"},{"key":"e_1_2_6_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(98)00017-2"},{"key":"e_1_2_6_208_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.119.6.889"},{"key":"e_1_2_6_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(01)00008-8"},{"key":"e_1_2_6_210_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(92)90012-O"},{"key":"e_1_2_6_211_1","doi-asserted-by":"publisher","DOI":"10.1159\/000027517"},{"key":"e_1_2_6_212_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5670"},{"key":"e_1_2_6_213_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343775"},{"key":"e_1_2_6_214_1","first-page":"269","article-title":"Human cornea organ cultures: epithelial\u2010endothelial interactions","volume":"16","author":"Yanoff M","year":"1977","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_215_1","first-page":"913","article-title":"Expression of gelatinases A and B, and TIMPs 1 and 2 during corneal wound healing","volume":"39","author":"Ye HQ","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_216_1","first-page":"2894","article-title":"Differential expression of MT1\u2010MMP (MMP\u201014) and collagenase III (MMP\u201013) genes in normal and wounded rat corneas","volume":"41","author":"Ye HQ","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_217_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-3904"},{"key":"e_1_2_6_218_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5158"},{"key":"e_1_2_6_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2009.08.024"},{"key":"e_1_2_6_220_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20041718"},{"key":"e_1_2_6_221_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0176"},{"key":"e_1_2_6_222_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8869"},{"key":"e_1_2_6_223_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-169X.2005.00797.x"},{"key":"e_1_2_6_224_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04925"},{"key":"e_1_2_6_225_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)02437-6"},{"key":"e_1_2_6_226_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.060037197"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.12227","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.12227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T16:52:49Z","timestamp":1715619169000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.12227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,2]]},"references-count":225,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/aos.12227"],"URL":"https:\/\/doi.org\/10.1111\/aos.12227","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,2]]},"assertion":[{"value":"2013-07-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}