{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:11:44Z","timestamp":1791353504975,"version":"4.3.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,7,15]],"date-time":"2013-07-15T00:00:00Z","timestamp":1373846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold> To evaluate the effectiveness of transepithelial cornea impregnation with riboflavin 0.1% by iontophoresis for collagen cross\u2010linking.<\/jats:p><jats:p><jats:bold>Material and methods:\u00a0<\/jats:bold> Transepithelial collagen cross\u2010linking by iontophoresis of riboflavin was performed in a series of 22 eyes of 19 patients with progressive keratoconus I\u2013II of Amsler classification. The riboflavin solution was administered by iontophoresis for 10\u2003min in total, after which standard surface UVA irradiation (370\u2003nm, 3\u2003mW\/cm<jats:sup>2<\/jats:sup>) was performed at a 5\u2010cm distance for 30\u2003min.<\/jats:p><jats:p><jats:bold>Results:\u00a0<\/jats:bold> The riboflavin\/UVA treatment resulted in a decrease in the average keratometry level from 46.47\u2003\u00b1\u20031.03 to 44.12\u2003\u00b1\u20031.12\u2003D 1\u2003year after the procedure. Corneal astigmatism decreased from 3.44\u2003\u00b1\u20030.48 to 2.95\u2003\u00b1\u20030.23\u2003D. Uncorrected distance visual acuity improved from 0.61\u2003\u00b1\u20030.44 up to 0.48\u2003\u00b1\u20030.41 (LogMAR). Preoperative and postoperative endothelial cell density remained unchanged at 2765\u2003\u00b1\u200321.15\u2003cells\/mm<jats:sup>2<\/jats:sup>.<\/jats:p><jats:p><jats:bold>Conclusion:\u00a0<\/jats:bold> Transepithelial collagen cross\u2010linking by iontophoresis might become an effective method for riboflavin impregnation of the corneal stroma reducing the duration of the procedure and being more comfortable for the patients. Further long\u2010term studies are necessary to complete the evaluation of the efficacy and risk spectrum of the modified cross\u2010linking technique.<\/jats:p>","DOI":"10.1111\/aos.12235","type":"journal-article","created":{"date-parts":[[2013,7,15]],"date-time":"2013-07-15T11:12:50Z","timestamp":1373886770000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":127,"title":["Transepithelial corneal collagen cross\u2010linking by iontophoresis of riboflavin"],"prefix":"10.1111","volume":"92","author":[{"given":"Guzel","family":"Bikbova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukharram","family":"Bikbov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2009.03.023"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2006.09.012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.06.031"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20090901-02"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S27170"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20100212-09"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.05.042"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2010.02207.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2009.12.003"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2010.02035.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2010.02067.x"},{"key":"e_1_2_7_13_1","first-page":"1397","article-title":"Pharmacokinetics and safety of transcorneal iontophoresis of tobramycin in the rabbit","volume":"29","author":"Rootman DS","year":"1988","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20090813-03"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000225720.38748.58"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3180334f78"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.205"},{"key":"e_1_2_7_18_1","first-page":"543","article-title":"Die Ionentherapie in der Augenheilkunde","volume":"46","author":"Wirtz R","year":"1908","journal-title":"Klin Monbl Augenheilkd"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.icu.0000233954.86723.25"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2008.11.036"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)02220-1"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2009.07.044"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.12235","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.12235","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.12235","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.12235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T22:04:46Z","timestamp":1695506686000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.12235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,15]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/aos.12235"],"URL":"https:\/\/doi.org\/10.1111\/aos.12235","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,15]]},"assertion":[{"value":"2013-07-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}