{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T09:16:52Z","timestamp":1776503812817,"version":"3.51.2"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,8,3]],"date-time":"2013-08-03T00:00:00Z","timestamp":1375488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Diabetic vitrectomy represents an end\u2010point of diabetic retinopathy progression. This study was designed to estimate long\u2010term incidence of diabetic vitrectomy and associated risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of prospectively collected data from a large diabetes centre between 1996 and 2010. Surgical history was obtained from The <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>anish <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ational <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>atient <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>egister.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The population consisted of 3980 patients with type 1 diabetes. Median follow\u2010up was 10.0\u00a0years. In total, 106 patients underwent diabetic vitrectomy in the observation period. Surgery indications were nonclearing vitreous haemorrhage (43%) or tractional retinal detachment (57%). The cumulative incidence rates of diabetic vitrectomy were 1.6% after 5\u00a0years and 2.9% after 10\u00a0years. When excluding patients with no or mild diabetic retinopathy, the corresponding rates were higher; 3.7% and 6.4%, respectively (p\u00a0&lt;\u00a00.001, log\u2010rank test). The risk of reaching diabetic vitrectomy increased in patients experiencing glycosylated haemoglobin A1c &gt;\u00a075\u00a0mmol\/mol in the observation period (p\u00a0&lt;\u00a00.001, hazard ratio: 3.9, Cox regression analysis). Systolic blood pressure \u2265\u00a0140\u00a0mmHg, diastolic blood pressure \u2265\u00a090\u00a0mmHg, diabetes duration, age, gender and nephropathy were not associated with an increased risk of reaching diabetic vitrectomy (p\u00a0&gt;\u00a00.05 for all variables).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Diabetic vitrectomy is rarely required in a type 1 diabetes population with varying degrees of retinopathy, but the risk increases markedly with poor metabolic control.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12249","type":"journal-article","created":{"date-parts":[[2013,8,3]],"date-time":"2013-08-03T06:04:58Z","timestamp":1375509898000},"page":"439-443","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Diabetic vitrectomy in a large type 1 diabetes patient population: long\u2010term incidence and risk factors"],"prefix":"10.1111","volume":"92","author":[{"given":"Christoffer","family":"Ostri","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Glostrup Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten","family":"la Cour","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Glostrup Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Lund\u2010Andersen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Glostrup Hospital University of Copenhagen Copenhagen Denmark"},{"name":"Steno Diabetes Center Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/157339911795843168"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00410281"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2005.00574.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(90)32611-8"},{"key":"e_1_2_6_6_1","unstructured":"Danish Health and Medicines Authority(2003):The Danish national patient register 1977\u20132002. 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