{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:42:35Z","timestamp":1793310155761,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T00:00:00Z","timestamp":1378857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Hubacz foundation"},{"name":"Stiftelsen Synfr\u00e4mjandet"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To study the epidemiology and risk factors of early\u2010 and late\u2010onset postoperative endophthalmitis (<jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>) and severe blebitis following trabeculectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective, single\u2010centre, observational study with a case\u2013control design in part. Patients sustaining <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> and severe blebitis following trabeculectomy or a combined trabeculectomy with a cataract extraction procedure performed from 1990 through 2008 and diagnosed from 1990 through 2012 were recorded at St Erik Eye Hospital. Incidence data were calculated with help from the hospital records. Notes data of cases and of six randomly selected but procedure matched control patients for each case were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The joint rate of infection was 0.46% or 34 incidents in 7402 procedures. The frequency of early (occurring &lt;6\u00a0weeks after surgery) onset <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> was 0.19%, late <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> was 0.19% and severe blebitis was 0.08%. Dominating aetiologies were staphylococci and streptococci. Overall, the infection severely impaired the visual function. Combined cataract and fistulating operations were less prone to develop late infections, p\u00a0=\u00a00.04, but no other decisive factors were identified in the case\u2013control study. Data collection for all trabeculectomy surgeries from 1998 and onward identified an increased rate for late infection with the use of mitomycin C (<jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content>), 8 in 1171 surgeries or 0.7%, versus no such use, 0 case of late <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> in 2136 surgeries, p\u00a0&lt;\u00a00.001.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Postoperative endophthalmitis is a devastating complication after trabeculectomy. The use of <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> increases the risk for delayed infection. Early <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> after trabeculectomy is clearly more common than <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> after cataract surgery. Developing efficacious prophylactic antibiotic regimens to reduce early <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> after penetrating filtering procedures should be a major priority in ophthalmic surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12257","type":"journal-article","created":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T12:49:31Z","timestamp":1378903771000},"page":"426-431","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Endophthalmitis and severe blebitis following trabeculectomy. 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