{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:53:56Z","timestamp":1777521236245,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T00:00:00Z","timestamp":1378857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To report on the therapeutic effect of intravitreal low\u2010dose bevacizumab for treatment for retinopathy of prematurity (<jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The single\u2010centre retrospective, non\u2010comparative case series study included all infants who consecutively underwent intravitreal injection of 0.375\u00a0mg bevacizumab (0.03\u00a0ml) under light sedation in topical anaesthesia as therapy of <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> in zone I or zone <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The clinical charts of 29 patients (57 eyes) with a median birth weight of 630\u00a0g (range: 290\u20131390\u00a0g) and median gestational age of 25\u00a0+\u00a01\u00a0weeks (range: 23\u00a0+\u00a01\u201330\u00a0weeks) were reviewed. Six children (12 eyes) were graded as <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> with zone I retinopathy and plus disease. The 23 remaining infants had extraretinal neovascularizations in zone <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> or partly zone <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>. The intravitreal bevacizumab injection was injected at a median age of 12\u00a0+\u00a01\u00a0weeks (range: 7\u00a0+\u00a04\u201321\u00a0+\u00a04), the median follow\u2010up was 4.2\u00a0months (range: from 3\u00a0days to 45.1\u00a0months). In all eyes treated, a regression of plus disease occurred within two to six days, retinal neovascularizations regressed within 2\u20133\u00a0weeks and pupillary rigidity improved. None except one child in exceptionally bad general health conditions needed a second intravitreal bevacizumab injection. In none of the infants, any ophthalmologic side\u2010effects of the bevacizumab application were detected during the follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The intravitreal injection of a low dose of 0.375\u00a0mg bevacizumab showed a high efficacy as treatment for <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>. 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