{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:47:32Z","timestamp":1787726852165,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T00:00:00Z","timestamp":1382918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the therapeutic effect of topical unoprostone isopropyl (unoprostone) on patients with retinitis pigmentosa (<jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty patients with typical forms of <jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content> were included in the study. Seventeen of 40 patients were treated with 0.12% topical unoprostone twice daily in a randomly selected eye. Patients underwent follow\u2010up examinations every 3\u00a0months after treatment. The efficacy of the treatment was monitored by visual acuity and visual field measurement testing using the Humphrey Field Analyzer (<jats:styled-content style=\"fixed-case\">HFA<\/jats:styled-content>: the central 10\u20102 programme). Moreover, 12 <jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content> patients who were included this study and 12 normal subjects were evaluated in terms of their macular blood flow of both eyes after instillation of unoprostone using the laser speckle method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One year after treatment, the \u2018macular sensitivity\u2019, calculated by <jats:styled-content style=\"fixed-case\">HFA<\/jats:styled-content> as the average sensitivity of the central 12 points, was preserved in the fellow eyes as well as the unoprostone\u2010treated eyes. On the other hand, that in the eyes of the control <jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content> patient was significantly decreased. Moreover, there were significantly greater improvements of the \u2018macular sensitivity\u2019 in the unoprostone\u2010treated eyes than the fellow eyes. The change ratios of macular blood flow obtained from both <jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content> patients and normal subjects were significantly increased in both the treated and the fellow eyes. No severe side\u2010effects were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results demonstrate that topical unoprostone might have a therapeutic efficacy in patients with <jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content> as a consequence of the macular blood flow improvement as well as its direct neuroprotective effect.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12293","type":"journal-article","created":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T11:47:20Z","timestamp":1382960840000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Therapeutic efficacy of topical unoprostone isopropyl in retinitis pigmentosa"],"prefix":"10.1111","volume":"92","author":[{"given":"Masato","family":"Akiyama","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Graduate School of Medical Sciences Kyushu University Higashi\u2010ku Fukuoka 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