{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:54:29Z","timestamp":1789674869821,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,12,21]],"date-time":"2013-12-21T00:00:00Z","timestamp":1387584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Mary and Georg C Ehrnrooth Foundation"},{"DOI":"10.13039\/501100013511","name":"Finnish Eye Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013511","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Glaukoomatukis\u00e4\u00e4ti\u00f6 LUX"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare the outcome of deep sclerectomy (<jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>) with and without mitomycin\u2010C (<jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content>) in patients with normal\u2010tension glaucoma (<jats:styled-content style=\"fixed-case\">NTG<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively analysed the results of 37 eyes of 37 consecutive patients with <jats:styled-content style=\"fixed-case\">NTG<\/jats:styled-content> (age; mean\u00a0\u00b1\u00a0<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>; 64\u00a0\u00b1\u00a07\u00a0years) who underwent <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content> with a collagen implant. Patients were randomized to the <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> groups. Subconjunctival <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> (0.4\u00a0mg\/ml for 3\u00a0min) was used intraoperatively in 15 of 37 eyes. We defined total success as 25% reduction in intraocular pressure (<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>) without medication. Follow\u2010up time was 12\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean preoperative <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> was significantly reduced from 15.2\u00a0\u00b1\u00a02.8\u00a0mmHg to 9.3\u00a0\u00b1\u00a02.7 (p\u00a0&lt;\u00a00.001) in the <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> group after 12\u2010month follow\u2010up and from 15.1\u00a0\u00b1\u00a02.9\u00a0mmHg to 11.8\u00a0\u00b1\u00a02.0 (p\u00a0&lt;\u00a00.001) in the non\u2010<jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> group. At 12\u00a0months, the mean <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> was significantly lower in the <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> group (p\u00a0=\u00a00.003) compared with the non\u2010<jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> group. Total success was achieved in 10 of 15 eyes (67%) in <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> group and in nine of 22 eyes (41%) in non\u2010<jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> group (p\u00a0=\u00a00.12). The number of glaucoma medications was decreased from 2.2\u00a0\u00b1\u00a00.8 to 0.5\u00a0\u00b1\u00a01.2 in <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> group (p\u00a0=\u00a00.001) and from 2.6\u00a0\u00b1\u00a01.0 to 0.5\u00a0\u00b1\u00a00.7 in non\u2010<jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> group (p\u00a0&lt;\u00a00.001). Goniopuncture was performed in seven eyes (47%) in the <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> group, compared with 16 eyes (73%) in the non\u2010<jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> group (p\u00a0=\u00a00.13). <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>\u00a0&lt;\u00a010\u00a0mmHg was achieved in seven of 15 eyes in the <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> group and in two of 22 in the non\u2010<jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> group (p\u00a0=\u00a00.009). Complication rate was low, and no difference between groups was evident.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Deep sclerectomy seems to be effective and safe in reducing <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">NTG<\/jats:styled-content>. Intraoperative use of <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> results in lower postoperative <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> 12\u2010month postoperatively without increased rate of complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12305","type":"journal-article","created":{"date-parts":[[2013,12,21]],"date-time":"2013-12-21T08:58:47Z","timestamp":1387616327000},"page":"701-706","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Deep sclerectomy in normal\u2010tension glaucoma with and without mitomycin\u2010c"],"prefix":"10.1111","volume":"92","author":[{"given":"Sakari","family":"Suominen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Helsinki University Central Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Harju","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Helsinki University Central Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena","family":"Kurvinen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Helsinki University Central Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eija","family":"Vesti","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Turku University Central Hospital Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200206000-00009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01069-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ijg.0000137869.18156.81"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(01)00964-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700148"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00263-3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.116.4.443"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2009.01630.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.10.1268"},{"key":"e_1_2_7_11_1","first-page":"95","volume-title":"Terminology and guidelines for glaucoma","author":"Heijl A","year":"2008"},{"key":"e_1_2_7_12_1","first-page":"15","volume-title":"Guidelines on design and reporting of glaucoma surgical trials","author":"Heuer DK","year":"2008"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-004-0181-9"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200208000-00003"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)73810-3"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2009.02030.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3181a2fa46"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2011.275"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(99)80079-0"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2009.01772.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2006.00654.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000055608"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(01)01032-X"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00391-2"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2009.01623.x"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.12305","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.12305","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.12305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:52:55Z","timestamp":1695495175000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.12305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,21]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1111\/aos.12305"],"URL":"https:\/\/doi.org\/10.1111\/aos.12305","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,21]]},"assertion":[{"value":"2012-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-12-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}