{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T16:16:14Z","timestamp":1789402574018,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T00:00:00Z","timestamp":1390435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>(1) To characterize the retrobulbar circulation in patients with optic disc drusen (<jats:styled-content style=\"fixed-case\">ODD<\/jats:styled-content>) using colour Doppler imaging; (2) to explore the differences in retrobulbar hemodynamics in patients with primary open\u2010angle glaucoma (<jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis using three diagnostic groups: patients with <jats:styled-content style=\"fixed-case\">ODD<\/jats:styled-content>, age\u2010matched healthy controls and age\u2010 and visual defect\u2010matched patients with <jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content>. Subjects with history of ocular trauma or ocular diseases including vascular\u2010related diseases were excluded. Kruskal\u2013Wallis and Spearman's correlation tests were performed to compare and explore the correlations between the hemodynamic parameters and visual field damage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty patients were included and equally divided between the three groups. Patients with <jats:styled-content style=\"fixed-case\">ODD<\/jats:styled-content> had lower systolic and diastolic flow velocities in the central retinal artery (<jats:styled-content style=\"fixed-case\">CRA<\/jats:styled-content>) when compared to healthy individuals, but no difference was found with the glaucoma group (p\u00a0&lt;\u00a00.005 versus healthy; p range 0.30\u20130.37 versus <jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content>). The systolic shift in flow patterns correlated with the extent of visual field defect in <jats:styled-content style=\"fixed-case\">ODD<\/jats:styled-content> patients (p\u00a0&lt;\u00a00.001, <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.78, confidence interval: \u22120.43 to \u22120.92), but not in <jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content> (p\u00a0=\u00a00.73). Short ciliary arteries from <jats:styled-content style=\"fixed-case\">ODD<\/jats:styled-content> patients had lower mean systolic flow velocities when compared to both healthy individuals and patients with <jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content> (p\u00a0&lt;\u00a00.01 versus healthy; p\u00a0\u2264\u00a00.04 versus <jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content>). The ophthalmic artery in <jats:styled-content style=\"fixed-case\">ODD<\/jats:styled-content> group had significantly higher mean blood velocities than in the <jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content> (p\u00a0=\u00a00.04), while showing a significant overlap in Doppler waveform variables to the control group (p range 0.08\u20130.97).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Similar to patients with glaucoma, individuals with <jats:styled-content style=\"fixed-case\">ODD<\/jats:styled-content> have low blood flow velocities in the vessels around the optic nerve head. Unlike patients with glaucoma, however, their <jats:styled-content style=\"fixed-case\">CRA<\/jats:styled-content>'s blood flow velocity patterns correlate with the extent of the visual field defects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12314","type":"journal-article","created":{"date-parts":[[2014,1,24]],"date-time":"2014-01-24T05:15:24Z","timestamp":1390540524000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Visual field loss in optic disc drusen patients correlates with central retinal artery blood velocity patterns"],"prefix":"10.1111","volume":"92","author":[{"given":"Lu\u00eds","family":"Abeg\u00e3o Pinto","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Lisbon's Center Hospitals \u2010 Central Lisbon Portugal"},{"name":"Department of Ophthalmology University Hospitals Leuven (UZ Leuven) Leuven 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