{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:53:39Z","timestamp":1767830019520,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T00:00:00Z","timestamp":1387843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the histologic correlate of the peripapillary ring (<jats:styled-content style=\"fixed-case\">PPR<\/jats:styled-content>) as the optic disc boundary, to measure it histomorphometrically and to assess its associations with glaucoma and axial length.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a light microscope, we measured the width of the <jats:styled-content style=\"fixed-case\">PPR<\/jats:styled-content> and optic nerve pia mater. We additionally had measured the axial length, length of parapapillary beta and gamma zones, and thickness of the sclera and choroid.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 83 human globes with a mean axial length of 26.1\u00a0\u00b1\u00a03.3\u00a0mm (range: 20.0\u201335.0\u00a0mm). In the non\u2010highly myopic (axial length &lt;26.5\u00a0mm) non\u2010glaucomatous eyes, mean <jats:styled-content style=\"fixed-case\">PPR<\/jats:styled-content> width was 55\u00a0\u00b1\u00a014\u00a0<jats:italic>\u03bc<\/jats:italic>m (range: 26\u201388\u00a0<jats:italic>\u03bc<\/jats:italic>m) and mean thickness of the optic nerve pia mater was 52\u00a0\u00b1\u00a022\u00a0<jats:italic>\u03bc<\/jats:italic>m (range: 20\u201384\u00a0<jats:italic>\u03bc<\/jats:italic>m). <jats:styled-content style=\"fixed-case\">PPR<\/jats:styled-content> width and pia mater thickness were significantly associated with each other (p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.001; correlation coefficient <jats:italic>r<\/jats:italic>\u00a0=\u00a00.37). <jats:styled-content style=\"fixed-case\">PPR<\/jats:styled-content> width increased significantly with longer axial length (p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.001; <jats:italic>r<\/jats:italic>\u00a0=\u00a00.35) and with the length of the peripapillary scleral flange (p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.02; <jats:italic>r<\/jats:italic>\u00a0=\u00a00.34). Pia mater thickness increased significantly with longer axial length (p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.03; <jats:italic>r<\/jats:italic>\u00a0=\u00a00.24) and with presence of glaucoma (p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.03). In eyes without parapapillary gamma zone, <jats:styled-content style=\"fixed-case\">PPR<\/jats:styled-content> was covered or was at least touched by the end of Bruch's membrane and separated the peripapillary choroid from the prelaminar optic nerve head tissue. In eyes with parapapillary gamma zone, <jats:styled-content style=\"fixed-case\">PPR<\/jats:styled-content> was the continuation of the optic nerve pia mater and reached the undersurface of the peripapillary retinal nerve fibre layer. In these eyes, Bruch's membrane started in a distance of up to 5\u00a0mm from <jats:styled-content style=\"fixed-case\">PPR<\/jats:styled-content>, and the thin space of peripapillary choroid ended by an attachment of Bruch's membrane to the thinned sclera.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Peripapillary ring width (mean: 55\u00a0\u00b1\u00a014\u00a0<jats:italic>\u03bc<\/jats:italic>m) increases slightly with longer axial length and is independent of glaucoma. It is strongly correlated with the pia mater thickness and is the continuation of the pia mater to the ocular surface.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12324","type":"journal-article","created":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T12:43:34Z","timestamp":1387889014000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Peripapillary ring: histology and correlations"],"prefix":"10.1111","volume":"92","author":[{"given":"Jost B.","family":"Jonas","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Medical Faculty Mannheim Heidelberg University Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard","family":"Holbach","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Friedrich\u2010Alexander University Erlangen\u2010N\u00fcrnberg Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songhomitra","family":"Panda\u2010Jonas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Medical Faculty Mannheim Heidelberg University Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0022"},{"key":"e_1_2_5_3_1","first-page":"391","article-title":"Das Colobom am Sehnerveneintritt und der Conus nach unten","volume":"51","author":"Elschnig A","year":"1900","journal-title":"Arch Augenheilkd"},{"key":"e_1_2_5_4_1","unstructured":"Elschnig(1900b):Der normale Sehnerveneintritt des menschlichen Auges. Denkschr. d. kaiserl. Akad. d. Wiss.70 Wien 1900. \u201cVorgelegt in der Sitzung am 12. October 1899.\u201d"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.1996.tb00054.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.1999.770103.x"},{"key":"e_1_2_5_7_1","first-page":"240","article-title":"Anatomy and physiology of the optic nerve head","volume":"78","author":"Hayreh SS","year":"1974","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1993.tb04974.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-013-0263-7"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2010.02022.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2010.02034.x"},{"key":"e_1_2_5_12_1","first-page":"621","article-title":"Definitionsentwurf der intra\u2010 und parapapill\u00e4ren Parameter f\u00fcr die Biomorphometrie des Nervus opticus","volume":"192","author":"Jonas JB","year":"1988","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1050223"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1989.tb00753.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00164651"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047237"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2010.02088.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.02.011"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(76)90489-X"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.09.054"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-2786"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.12324","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.12324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T16:36:13Z","timestamp":1695486973000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.12324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,24]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/aos.12324"],"URL":"https:\/\/doi.org\/10.1111\/aos.12324","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,24]]},"assertion":[{"value":"2013-10-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-12-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}