{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:41:15Z","timestamp":1778287275778,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,24]],"date-time":"2014-01-24T00:00:00Z","timestamp":1390521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine the correlation between ocular blood flow velocities and ocular pulse amplitude (<jats:styled-content style=\"fixed-case\">OPA<\/jats:styled-content>) in glaucoma patients using colour Doppler imaging (<jats:styled-content style=\"fixed-case\">CDI<\/jats:styled-content>) waveform analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A prospective, observer\u2010masked, case\u2010control study was performed.<jats:styled-content style=\"fixed-case\">OPA<\/jats:styled-content>and blood flow variables from central retinal artery and vein (<jats:styled-content style=\"fixed-case\">CRA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">CRV<\/jats:styled-content>), nasal and temporal short posterior ciliary arteries (<jats:styled-content style=\"fixed-case\">NPCA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">TPCA<\/jats:styled-content>) and ophthalmic artery (<jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>) were obtained through dynamic contour tonometry and<jats:styled-content style=\"fixed-case\">CDI<\/jats:styled-content>, respectively. Univariate and multiple regression analyses were performed to explore the correlations between<jats:styled-content style=\"fixed-case\">OPA<\/jats:styled-content>and retrobulbar<jats:styled-content style=\"fixed-case\">CDI<\/jats:styled-content>waveform and systemic cardiovascular parameters (blood pressure, blood pressure amplitude, mean ocular perfusion pressure and peripheral pulse).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and ninety\u2010two patients were included [healthy controls: 55; primary open\u2010angle glaucoma (<jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content>): 74; normal\u2010tension glaucoma (<jats:styled-content style=\"fixed-case\">NTG<\/jats:styled-content>): 63].<jats:styled-content style=\"fixed-case\">OPA<\/jats:styled-content>was statistically different between groups (Healthy: 3.17\u00a0\u00b1\u00a01.2\u00a0mmHg;<jats:styled-content style=\"fixed-case\">NTG<\/jats:styled-content>: 2.58\u00a0\u00b1\u00a01.2\u00a0mmHg;<jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content>: 2.60\u00a0\u00b1\u00a01.1\u00a0mmHg; p\u00a0&lt;\u00a00.01), but not between the glaucoma groups (p\u00a0=\u00a00.60). Multiple regression models to explain<jats:styled-content style=\"fixed-case\">OPA<\/jats:styled-content>variance were made for each cohort (healthy: p\u00a0&lt;\u00a00.001,<jats:italic>r<\/jats:italic>\u00a0=\u00a00.605;<jats:styled-content style=\"fixed-case\">NTG<\/jats:styled-content>: p\u00a0=\u00a00.003,<jats:italic>r<\/jats:italic>\u00a0=\u00a00.372;<jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content>: p\u00a0&lt;\u00a00.001,<jats:italic>r<\/jats:italic>\u00a0=\u00a00.412).<jats:styled-content style=\"fixed-case\">OPA<\/jats:styled-content>was independently associated with retrobulbar<jats:styled-content style=\"fixed-case\">CDI<\/jats:styled-content>parameters in the healthy subjects and<jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content>patients (healthy<jats:styled-content style=\"fixed-case\">CRV<\/jats:styled-content>resistance index:<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a03.37,<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.16\u20136.59; healthy<jats:styled-content style=\"fixed-case\">NPCA<\/jats:styled-content>mean systolic\/diastolic velocity ratio:<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a01.34,<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.52\u20132.15;<jats:styled-content style=\"fixed-case\">POAG TPCA<\/jats:styled-content>mean systolic velocity:<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a00.14,<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>0.05\u20130.23).<jats:styled-content style=\"fixed-case\">OPA<\/jats:styled-content>in the<jats:styled-content style=\"fixed-case\">NTG<\/jats:styled-content>group was associated with diastolic blood pressure and pulse rate (<jats:italic>\u03b2\u00a0<\/jats:italic>=\u00a0\u22120.04,<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: \u22120.06 to \u22120.01;<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a0\u22120.04,<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: \u22120.06 to \u22120.001, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Vascular\u2010related models provide a better explanation to<jats:styled-content style=\"fixed-case\">OPA<\/jats:styled-content>variance in healthy individuals than in glaucoma patients. The variables that influence<jats:styled-content style=\"fixed-case\">OPA<\/jats:styled-content>seem to be different in healthy,<jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">NTG<\/jats:styled-content>patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12340","type":"journal-article","created":{"date-parts":[[2014,1,24]],"date-time":"2014-01-24T05:54:55Z","timestamp":1390542895000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Ocular pulse amplitude and Doppler waveform analysis in glaucoma patients"],"prefix":"10.1111","volume":"92","author":[{"given":"Lu\u00eds","family":"Abeg\u00e3o Pinto","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Centro Hospitalar Lisboa Central Lisbon Portugal"},{"name":"Department of Pharmacology and Neurosciences Faculty of Medicine Lisbon University Lisbon 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