{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T18:07:34Z","timestamp":1788977254892,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T00:00:00Z","timestamp":1391040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare the safety and efficacy of a single subconjunctival injection of methylprednisolone and a standard postoperative steroid regimen in terms of intraocular inflammation and intraocular pressure (<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>) after uncomplicated phacoemulsification surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two groups of 25 patients each were included in this prospective randomized controlled trial. Patients in the injection group were given a subconjunctival injection of 20\u00a0mg methylprednisolone and the topical group received the conventional postoperative care with steroid eye drops (dexamethasone 1\u00a0mg\/ml). The patients were examined 1\u00a0week and 1\u00a0month after surgery. Slit\u2010lamp evaluation of anterior chamber inflammation and <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> were performed. Changes in <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> of \u22652.4\u00a0mmHg were considered clinically relevant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the injection group, mean <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> decreased from 15.4\u00a0\u00b1\u00a02.2\u00a0mmHg (baseline) to 14.1\u00a0\u00b1\u00a03.2\u00a0mmHg at 1\u00a0week (p\u00a0=\u00a00.03). The topical group had a stable <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> at 1\u00a0week (16.3\u00a0\u00b1\u00a02.6\u00a0mmHg) compared to baseline (16.1\u00a0\u00b1\u00a02.7\u00a0mmHg; p\u00a0=\u00a00.74). At 1\u00a0month, mean <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> was 14.3\u00a0\u00b1\u00a02.6\u00a0mmHg (p\u00a0=\u00a00.03) in the injection group and 15.6\u00a0\u00b1\u00a02.3\u00a0mmHg (p\u00a0=\u00a00.2) in the topical group. The intragroup changes were neither statistically significant nor clinically relevant at any postoperative visit. Both groups had the highest values of intraocular inflammation at the 1\u2010week postoperative visit, followed by a decline to barely traceable levels at 1\u00a0month. The difference was not clinically relevant at any postoperative visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The subconjunctival injection of methylprednisolone appears to be as safe and effective as the conventional treatment, and it might therefore be considered for treatment of individuals with compliance issues.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12358","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T12:51:40Z","timestamp":1391086300000},"page":"623-628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Comparison of peroperative subconjunctival injection of methylprednisolone and standard postoperative steroid drops after uneventful cataract surgery"],"prefix":"10.1111","volume":"92","author":[{"given":"Nikolaos","family":"Merkoudis","sequence":"first","affiliation":[{"name":"Department of Neuroscience\/Ophthalmology Uppsala 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