{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:06:28Z","timestamp":1791439588588,"version":"4.3.3"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,2,25]],"date-time":"2014-02-25T00:00:00Z","timestamp":1393286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Key Technology R&D Program of the Ministry of Science and Technology","award":["2012BAH05F05 and 2013BAH19F04"],"award-info":[{"award-number":["2012BAH05F05 and 2013BAH19F04"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To examine the relationship between major ocular diseases and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The population\u2010based longitudinal study Beijing Eye Study was performed in 2001 and repeated in 2011. The participants underwent a detailed ophthalmic examination at baseline in 2001.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 4439 subjects examined in 2001, 2695 (60.7%) subjects returned for the follow\u2010up examination in 2011, while 379 (8.5%) subjects were dead and 1365 (30.8%) subjects were alive, however, did not agree to be re\u2010examined. In multivariate regression analysis, mortality was significantly associated with the systemic parameters of older age (p\u00a0&lt;\u00a00.001; Odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>): 1.07; 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>): 1.05, 1.09), male gender (p\u00a0&lt;\u00a00.001; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 0.56; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.40, 0.78), lower level of education (p\u00a0&lt;\u00a00.001; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 0.66; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.59, 0.74) and smoking (p\u00a0&lt;\u00a00.001; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1.84; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.36, 2.49) and with the ocular parameters of presence of diabetic retinopathy (p\u00a0=\u00a00.002; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 2.26; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.34, 3.81), non\u2010glaucomatous optic nerve damage (p\u00a0=\u00a00.001; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 4.90; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.90, 12.7) and higher degree of nuclear cataract (p\u00a0=\u00a00.002; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1.29; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.10, 1.52). In that model, mortality was not significantly (all p\u00a0&gt;\u00a00.05) associated with refractive error, cortical or subcapsular posterior cataract, intraocular pressure, best corrected visual acuity, visual field defects, prevalence of age\u2010related macular degeneration, retinal vein occlusions, open\u2010angle glaucoma and angle\u2010closure glaucoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>After adjustment for age, gender, level of education and smoking, mortality was significantly higher in subjects with diabetic retinopathy, non\u2010glaucomatous optic nerve damage and nuclear cataract. Other major ophthalmic parameters and disorders such as hyperopia, myopia, high myopia, pterygium, age\u2010related macular degeneration, retinal vein occlusion, glaucoma and cortical or nuclear cataract were not significantly associated with mortality in the multivariate analysis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12370","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T02:02:40Z","timestamp":1393380160000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Ocular diseases and 10\u2010year mortality: The <scp>B<\/scp>eijing <scp>E<\/scp>ye <scp>S<\/scp>tudy 2001\/2011"],"prefix":"10.1111","volume":"92","author":[{"given":"Ya Xing","family":"Wang","sequence":"first","affiliation":[{"name":"Beijing Institute of Ophthalmology Beijing Tongren Hospital Capital University of Medical Science Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing 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