{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:28:30Z","timestamp":1791203310234,"version":"4.2.0"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T00:00:00Z","timestamp":1394496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008273","name":"\u00d8jenfonden","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008273","id-type":"DOI","asserted-by":"crossref"}]},{"name":"\u00d8jenforeningen"},{"name":"Synoptikfonden"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate retinal trunk vessel diameters in subjects with autosomal dominant optic atrophy (<jats:styled-content style=\"fixed-case\">ADOA<\/jats:styled-content>) and mutation\u2010free healthy relatives.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study included 52 <jats:styled-content style=\"fixed-case\">ADOA<\/jats:styled-content> patients with the optic atrophy 1 (<jats:italic><jats:styled-content style=\"fixed-case\">OPA<\/jats:styled-content>1)<\/jats:italic> exon 28 (c.2826_2836delins<jats:styled-content style=\"fixed-case\">GGATGCTCCA<\/jats:styled-content>) mutation (age 8.6\u201383.5\u00a0years) (best\u2010corrected visual acuity (<jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content>) 8\u201394 Early Treatment Diabetic Retinopathy Study (<jats:styled-content style=\"fixed-case\">ETDRS<\/jats:styled-content>) letters) and 55 mutation\u2010free first\u2010degree healthy relatives (age 8.9\u201368.7\u00a0years, <jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content> 80\u201399). Analysis of fundus photographs provided integrated magnification\u2010corrected measures of retinal vessel diameters (central retinal artery equivalent, <jats:styled-content style=\"fixed-case\">CRAE<\/jats:styled-content>, and central retinal vein equivalent, <jats:styled-content style=\"fixed-case\">CRVE<\/jats:styled-content>). Statistical analysis was corrected for age, gender, spherical equivalent refraction, axial length and mean arterial blood pressure (<jats:styled-content style=\"fixed-case\">MABP<\/jats:styled-content>) in a mixed model analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Retinal arteries and veins were thinner in <jats:styled-content style=\"fixed-case\">ADOA<\/jats:styled-content> than in healthy controls (<jats:styled-content style=\"fixed-case\">CRAE<\/jats:styled-content> (mean\u00a0\u00b1\u00a02 standard deviations (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>)) 153.9\u00a0\u00b1\u00a041.0\u00a0<jats:italic>\u03bc<\/jats:italic>m and <jats:styled-content style=\"fixed-case\">CRVE<\/jats:styled-content> 236.1\u00a0\u00b1\u00a042.0\u00a0<jats:italic>\u03bc<\/jats:italic>m in <jats:styled-content style=\"fixed-case\">ADOA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CRAE<\/jats:styled-content> 172.5\u00a0\u00b1\u00a025.0\u00a0<jats:italic>\u03bc<\/jats:italic>m (p\u00a0=\u00a00.0004) and <jats:styled-content style=\"fixed-case\">CRVE<\/jats:styled-content> 254.2\u00a0\u00b1\u00a037.6\u00a0<jats:italic>\u03bc<\/jats:italic>m (p\u00a0=\u00a00.0019) in healthy controls). <jats:styled-content style=\"fixed-case\">MABP<\/jats:styled-content> was comparable in the two groups (p\u00a0=\u00a00.18), and in both groups, <jats:styled-content style=\"fixed-case\">CRAE<\/jats:styled-content> decreased with increasing <jats:styled-content style=\"fixed-case\">MABP<\/jats:styled-content> (p\u00a0=\u00a00.01 and p\u00a0&lt;\u00a00.0001, respectively). In <jats:styled-content style=\"fixed-case\">ADOA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CRAE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CRVE<\/jats:styled-content> decreased with age (p\u00a0=\u00a00.011 and p\u00a0=\u00a00.020, respectively) and <jats:styled-content style=\"fixed-case\">CRAE<\/jats:styled-content> decreased with decreasing <jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content> (p\u00a0=\u00a00.011). In patients with <jats:styled-content style=\"fixed-case\">ADOA<\/jats:styled-content> and in healthy controls, <jats:styled-content style=\"fixed-case\">CRAE<\/jats:styled-content> decreased with decreasing average macular ganglion cell\u2013inner plexiform layer (<jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IPL<\/jats:styled-content>) thickness (p\u00a0=\u00a00.0017 and p\u00a0=\u00a00.0057, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Narrow retinal arteries and veins were associated not only with the severity of <jats:styled-content style=\"fixed-case\">ADOA<\/jats:styled-content> but with ganglion cell volume in patients with <jats:styled-content style=\"fixed-case\">ADOA<\/jats:styled-content> and in healthy subjects. This suggests that narrow vessels are a consequence rather than the cause of inner retinal hypoplasia or atrophy, although longitudinal studies are needed to confirm this hypothesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12378","type":"journal-article","created":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T05:22:51Z","timestamp":1394515371000},"page":"670-674","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Retinal vessel diameters decrease with macular ganglion cell layer thickness in autosomal dominant optic atrophy and in healthy subjects"],"prefix":"10.1111","volume":"92","author":[{"given":"Cecilia","family":"R\u00f6nnb\u00e4ck","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Glostrup Hospital Glostrup Denmark"},{"name":"Faculty of Health Sciences University of Copenhagen Copenhagen 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